28,631 research outputs found
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Developing a taxonomy for the understanding of business and it alignment paradigms and tools
The alignment of information technology with business objectives tends to be a managerial priority in modern organisations. Thus, practitioners and researchers have proposed different approaches to assess this relationship, some following similar approaches whilst others proposing different ones. The variety of approaches proposed, however, has created confusion about the applicability and context in which these approaches can be used. Thus, aiming to tackle this challenge, this paper proposes a taxonomy that organises and compares studies of alignment assessment in terms of their theoretical constructors and their practical use. The taxonomy is build around two research sources: a) a review of the literature of alignment and b) a framework for comparing IS methodologies. The structure of the taxonomy permits insights into studies by means of six theoretical (objective, nature of strategy, paradigm, dimension, type of measurement, model) and six practical constructors (audience, scope, output, techniques, product, target). The taxonomy is then applied to six assessment studies. The benchmarking analysis of these helped to identify their theoretical basis and its practical use, and confirms the need for more practical mechanisms to assess alignment. Additionally, it becomes apparent that process perspectives and social understanding of alignment are the two main paradigms for alignment
Developments in aircraft jet noise technology
Significant developments in two areas of jet noise technology are described: the development of jet noise technology relative to coannular nozzles of all types, and a recent approach to the analysis of flight effects that appears to allow simulated flight effects results to be transformed to actual flight conditions with a high degree of confidence. The coannular nozzle section presents results applicable to high-bypass-ratio turbofan engines, as well as current work on inverted-profile coannular nozzles applicable to low-bypass-ratio turbofan engines suitable for use in future supersonic cruise aircraft
Maternal haemodynamic function differs in preâeclampsia when it is associated with a smallâforâgestationalâage newborn: a prospective cohort study
Objective
To describe maternal haemodynamic differences in gestational hypertension with smallâforâgestationalâage babies (HDP + SGA), gestational hypertension with appropriateâforâgestationalâage babies (HDPâonly) and control pregnancies.
Design
Prospective cohort study.
Setting
Tertiary Hospital, UK.
Population
Women with gestational hypertension and healthy pregnant women.
Methods
Maternal haemodynamic indices were measured using a nonâinvasive Ultrasound Cardiac Output Monitor (USCOMâ1AÂź) and corrected for gestational age and maternal characteristics using deviceâspecific reference ranges.
Main outcome measures
Maternal cardiac output, stroke volume, systemic vascular resistance.
Results
We included 114 HDP + SGA, 202 HDPâonly and 401 control pregnancies at 26â41 weeks of gestation. There was no significant difference in the mean arterial blood pressure (110 versus 107 mmHg, P = 0.445) between the two HDP groups at presentation. Pregnancies complicated by HDP + SGA had significantly lower median heart rate (76 versus 85 bpm versus 83 bpm), lower cardiac output (0.85 versus 0.98 versus 0.97 MoM) and higher systemic vascular resistance (1.4 versus 1.0 versus 1.2 MoM) compared with control and HDPâonly pregnancies, respectively (all P < 0.05).
Conclusion
Women with HDP + SGA present with more severe haemodynamic dysfunction than HDPâonly. Even HDPâonly pregnancies exhibit impaired haemodynamic indices compared with normal pregnancies, supporting a role of the maternal cardiovascular system in gestational hypertension irrespective of fetal size. Central haemodynamic changes may play a role in the pathogenesis of preâeclampsia and should be considered alongside placental aetiology
Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn
Background:
Gastrin-releasing peptide (GRP) and its receptor have been shown to play an important role in the sensation of itch. However, although GRP immunoreactivity has been detected in the spinal dorsal horn, there is debate about whether this originates from primary afferents or local excitatory interneurons. We therefore examined the relation of GRP immunoreactivity to that seen with antibodies that label primary afferent or excitatory interneuron terminals. We tested the specificity of the GRP antibody by preincubating with peptides with which it could potentially cross-react. We also examined tissue from a mouse line in which enhanced green fluorescent protein (EGFP) is expressed under control of the GRP promoter.<p></p>
Results:
GRP immunoreactivity was seen in both primary afferent and non-primary glutamatergic axon terminals in the superficial dorsal horn. However, immunostaining was blocked by pre-incubation of the antibody with substance P, which is present at high levels in many nociceptive primary afferents. EGFP+ cells in the GRP-EGFP mouse did not express Pax2, and their axons contained the vesicular glutamate transporter 2 (VGLUT2), indicating that they are excitatory interneurons. In most cases, their axons were also GRP-immunoreactive. Multiple-labelling immunocytochemical studies indicated that these cells did not express either of the preprotachykinin peptides, and that they generally lacked protein kinase CÎł, which is expressed by a subset of the excitatory interneurons in this region.<p></p>
Conclusions:
These results show that GRP is expressed by a distinct population of excitatory interneurons in laminae I-II that are likely to be involved in the itch pathway. They also suggest that the GRP immunoreactivity seen in primary afferents in previous studies may have resulted from cross-reaction of the GRP antibody with substance P or the closely related peptide neurokinin A
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Using tactical and operational factors to assess strategic alignment: an SME study
The strategic use of Information Technology (IT), better known as strategic alignment, has significantly increased, as a result of the strong dependence of organisational activity on Information Systems (IS) and their related technologies. Strategic alignment is considered as a key element to improve performance on organisations, enhance efficiency and allow organisations to be more competitive in their respective industry. One of the first steps towards achieving strategic alignment is to have adequate means to measure it. Current assessment approaches, though, are mainly focused at the strategic level but provide little insight at tactical and operational levels, which are recognized as important areas for achieving strategic alignment. Furthermore, most of the existing approaches are tested in large organisations and there is little research on assessing the effectiveness of these approaches for Small and Medium Enterprises (SMEs). This paper proposes an alternative instrument that rather than focusing only at the strategic level it aims to have a better understanding by measuring alignment at tactical and operational levels. Finally this paper presents the findings of applying this instrument on an SME
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