34 research outputs found
Force Measurements of TCR/pMHC Recognition at T Cell Surface
Get PDFThe rupture forces and adhesion frequencies of single recognition complexes between an affinity selected peptide/MHC complex and a TCR at a murine hybridoma surface were measured using Atomic Force Microscopy. When the CD8 coreceptor is absent, the adhesion frequency depends on the nature of the peptide but the rupture force does not. When CD8 is present, no effect of the nature of the peptide is observed. CD8 is proposed to act as a time and distance lock, enabling the shorter TCR molecule to bridge the pMHC and have time to finely read the peptide. Ultimately, such experiments could help the dissection of the sequential steps by which the TCR reads the peptide/MHC complex in order to control T cell activation
I-region-restricted long-term cultured t cells with helper function for thymic cytotoxic precursor cells.
No full textSecondary mouse mixed lymphocyte reaction (mlr) in vitro: correlation between primed cells reactivity and serological typing for ia specificities.
No full textI region-restricted t cell line stimulated with hapten-treated syngeneic cells: selection of clones with reactivity for both allogeneic ia determinants and self-i-a plus hapten.
No full textMultiple cytolytic t-cell clones with distinct cross-reactivity patterns coexist in anti-self + hapten cell lines.
No full textCharacterization of suppressive immunoglobulin-binding factor (ibf). I. Production of ibf by a theta-positive lymphoma (l-5178-y).
No full textCorrelation between serologic and cellular methods for the defini- tion of ia specificities.
No full textFormation scientifique des patients atteints de pathologies auto-immunes : première expérimentation d’une web-conférence en France
No full textInternational audienc
