Parley P. Pratt: The Apostle Paul of Mormonism

After Joseph Smith and Brigham Young, Parley P. Pratt was the most influential figure in early Mormon history and culture. Missionary, pamphleteer, theologian, historian, and martyr, Pratt was perennially stalked by controversy--regarded, he said, almost as an Angel by thousands and counted an Imposter by tens of thousands. Tracing the life of this colorful figure from his hardscrabble origins in upstate New York to his murder in 1857, Terryl Givens and Matthew Grow explore the crucial role Pratt played in the formation and expansion of early Mormonism. One of countless ministers inspired by the antebellum revival movement known as the Second Great Awakening, Pratt joined the Mormons in 1830 at the age of twenty three and five years later became a member of the newly formed Quorum of the Twelve Apostles, which vaulted him to the forefront of church leadership for the rest of his life. Pratt\u27s missionary work--reaching from Canada to England, from Chile to California--won hundreds of followers, but even more important were his voluminous writings. Through books, newspaper articles, pamphlets, poetry, fiction, and autobiography, Pratt spread the Latter-day Saint message, battled the many who reviled it, and delineated its theology in ways that still shape Mormon thought. Drawing on letters, journals, and other rich archival sources, Givens and Grow examine not only Pratt\u27s writings but also his complex personal life. A polygamist who married a dozen times and fathered thirty children, Pratt took immense joy in his family circle even as his devotion to Mormonism led to long absences that put heavy strains on those he loved. It was during one such absence, a mission trip to the East, that the estranged husband of his twelfth wife shot and killed him--a shocking conclusion to a life that never lacked in drama.https://scholarship.richmond.edu/bookshelf/1073/thumbnail.jp

Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos

Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Society of Toxicology for personal use, not for redistribution. The definitive version was published in Toxicological Sciences 85 (2005): 683-693, doi:10.1093/toxsci/kfi116.2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant that causes altered heart morphology, circulatory impairment, edema, hemorrhage, and early life stage mortality in fish. TCDD toxicity is largely dependent upon the aryl hydrocarbon receptor, but understanding of the molecular mechanism of cardiovascular embryotoxicity remains incomplete. In order to identify genes potentially involved in cardiovascular impacts, we constructed custom cDNA microarrays consisting of 4,896 zebrafish adult heart cDNA clones and over 200 genes with known developmental, toxicological, and housekeeping roles. Gene expression profiles were obtained for 3-day old zebrafish following early embryonic exposure to either 0.5 or 5.0 nM TCDD. 516 clones were significantly differentially expressed (p-value < 0.005) under at least one treatment condition; 123 high-priority clones were selected for further investigation. CYP1A, CYP1B1, and other members of the AHR gene battery, were strongly and dose-dependently induced by TCDD. Importantly, altered expression of cardiac sarcomere components, including cardiac troponin T2 and multiple myosin isoforms, was consistent with the hypothesis that TCDD causes dilated cardiomyopathy. Observed increases in expression levels of mitochondrial energy transfer genes also may be related to cardiomyopathy. Other TCDD-responsive genes included fatty acid and steroid metabolism enzymes, ribosomal and signal transduction proteins, and 18 ESTs with no known protein homologs. As the first broadscale study of TCDD-modulated gene expression in a non-mammalian system, this work provides an important perspective on mechanisms of TCDD toxicity.This work was supported by funding from the National Institutes of Health

Addressing Prediabetes in Childhood Obesity Treatment Programs: Support from Research and Current Practice

Background: Type 2 diabetes mellitus (T2DM) and prediabetes have increased in prevalence among overweight and obese children, with significant implications for long-term health. There is little published evidence on the best approaches to care of prediabetes among overweight youth or the current practices used across pediatric weight management programs. Methods: This article reviews the literature and summarizes current practices for screening, diagnosis, and treatment of prediabetes at childhood obesity treatment centers. Findings regarding current practice were based on responses to an online survey from 28 pediatric weight management programs at 25 children's hospitals in 2012. Based on the literature reviewed, and empiric data, consensus support statements on prediabetes care and T2DM prevention were developed among representatives of these 25 children's hospitals' obesity clinics. Results: The evidence reviewed demonstrates that current T2DM and prediabetes diagnostic parameters are derived from adult-based studies with little understanding of clinical outcomes among youth. Very limited evidence exists on preventing progression of prediabetes. Some evidence suggests that a significant proportion of obese youth with prediabetes will revert to normoglycemia without pharmacological management. Evidence supports lifestyle modification for children with prediabetes, but further study of specific lifestyle changes and pharmacological treatments is needed. Conclusion: Evidence to guide management of prediabetes in children is limited. Current practice patterns of pediatric weight management programs show areas of variability in practice, reflecting the limited evidence base. More research is needed to guide clinical care for overweight youth with prediabetes.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140337/1/chi.2013.0158.pd

"Saints Observed": Outside Observations of Mormon Life

A Review Essay on Saints Observed: Studies of Mormon Village Life, 1850-2005 and Fourt Classic Mormon Village Studie

The Korean War Identification Project : 30 years of expanding scope and complexity in the accounting of American war dead

The Korean War claimed approximately 36,500 American service member casualties in its 3 years, of which nearly 7600 are still unaccounted for. The Korea 208 (K208) Project began in 2011 to more strategically address the highly commingled nature of 208 boxes of human remains that were repatriated from North Korea to the United Nations Command in the early 1990s and subsequently turned over to the Central Identification Laboratory, Hawaii (now Defense POW/MIA Accounting Agency [DPAA]) for analysis and identification. The K208 was further expanded by the recovery of remains from Joint Recovery Operations (JROs) in North Korea between 1996 and 2005, which revealed, among other issues, the presence of non-U.S. casualties and crossover of elements between these two assemblages. More recently, 55 boxes of human remains (known as the K55) were repatriated from North Korea in 2018 with many of the same commingling and assemblage crossover issues originally presented by the K208. Additionally, there has been an increased push to disinter more than 800 unknown Korean War service members buried at the National Memorial Cemetery of the Pacific (also known as the Punchbowl) in Honolulu, which represent casualties recovered from both North and South Korea that had undergone prior analysis in the 1950s and 1960s. Subsequent examination has revealed that many Punchbowl remains are commingled despite being thought to have been originally buried as discrete individuals. Because of these developments, the K208 Project has grown in complexity and scope, thus changing its name to the Korean War Identification Project (KWIP) in 2017. Now under its purview are the original accessions from the K208 and JROs as well as the K55 and Punchbowl, representing the largest identification project within the DPAA. A robust and defensible identification process begins with an initial triage of the remains, followed by a systematic process of segregation, consolidation, and corroboration leading to identification. This unique case of highly commingled human remains, involving thousands of missing persons from varied proveniences, highlights the challenges and successes of a multi-disciplinary approach involving historians, anthropologists, odontologists, and DNA and isotope specialists at the forefront, while also working with family members towards resolution. As of December 31, 2020, the KWIP has identified a total of 591 service members and continues to seek ways to innovate and improve both the quantity and quality of its work