847 research outputs found
Highly-functionalised difluorinated cyclohexane polyols via the Diels–Alder reaction : regiochemical control via the phenylsulfonyl group
A difluorinated dienophile underwent cycloaddition reactions with a range of furans to afford cycloadducts whichcould be processed regio- and stereoselectively via episulfonium ions, generated by the reaction between their alkenyl groups and phenylsulfenyl chloride. The oxabicyclic products were oxidised to the phenylsulfonyl level and ring opened via E1CB or reductive desulfonative pathways to afford, ultimately, difluorinated cyclohexene or cyclohexane polyols
Perennial Warm-Season Grass Forages Impact on Cow-Calf Profitability in the Fescue Belt
Incorporating a perennial warm- season grass (WSG) into tall fescue (Lolium arundina-ceum [Schreb.] Darbysh.) forage systems in the fescue belt can help avoid the effects of fescue toxicosis on beef cattle (Bos taurus) reproduction and animal performance and provide forage during summer when fescue production is low. However, little information is available on the economics of incorporating WSG into fescue-based forage systems. We developed a simulation model to compare profitability of three forage systems—100% tall fescue, 70% tall fescue/30% bermudagrass (Cynodon dactylon), and 70% tall fescue/ 30% switchgrass (Panicum virgatum)—while also comparing spring- and fall-calving sea-sons on model beef cattle cow-calf operations in the fescue belt. Incorporating switch-grass increased profitability of tall fescue forage systems in both spring- and fall- calving herds, while adding bermudagrass increased profitability in spring-calving herds but not fall-calving herds. Spring-calving herds benefited the most from incorporating WSG, with profitability increases of 372 per hectare for switchgrass and bermudagrass, respectively, over the 100% tall fescue system. The order of profitability of forage systems did not change with randomly simulated decreases in rainfall and associated increased hay- feeding days, but with annual rainfall \u3e88% of the long- term average, fall- calving 100% tall fescue was more profitable than fall- calving 70% tall fescue/30% bermuda grass. Of the scenarios modeled, the results of the simulation suggest that a profit-maximizing producer would utilize a 70% tall fescue/30% switchgrass forage system
Determination of the carrier concentration in InGaAsN∕GaAs single quantum wells using Raman scattering
Raman scattering from longitudinal optical phonon-plasmon coupled mode was observed in a series of InGaAsN∕GaAs single quantum well samples grown by metalorganic vapor phase epitaxy. The phonon-plasmon mode spectra were fitted with the dielectric constant function based on Drude model that contains contributions from both lattice vibrations and conduction electrons. The carrier concentration is calculated directly from the plasmon frequency, which is obtained from the fitting procedure. An empirical expression for the electron concentration, [n], in InGaAsN∕GaAs samples is determined as [n]≈{2.35×1016(ωm−502)}cm−3, where ωm is the peak of the upper frequency branch, L+, of the phonon-plasmon mode measured in unit of cm−1. The phonon-plasmon coupled mode was also investigated in rapid thermally annealed samples
Development of Drugs for Nontuberculous Mycobacterial Disease:Clinicians’ Interpretation of a US Food and Drug Administration Workshop
The US Food and Drug Administration convened a workshop to discuss clinical trial design challenges and considerations related to the treatment of nontuberculous mycobacterial pulmonary disease, to include topics such as clinical trial end points, duration, and populations. The clinicians participating in the meeting provide here their interpretation of the discussion, which included US Food and Drug Administration and industry representatives. The treatment of nontuberculous mycobacterial pulmonary disease typically includes multiple antibiotics for a prolonged period and can be difficult to tolerate; there is a great need for new treatment options. Most individuals have a microbiologic response to therapy, but data correlating decreasing bacillary load with patient-reported outcomes or measured functional improvement are lacking. Accordingly, trial designs for new therapeutic agents should incorporate both microbiologic and clinical outcome measures and select appropriate study candidates with capacity for measurable change of such outcome measures. The need for shorter study designs, early primary end points, and placebo control arms was highlighted during the workshop
A Study of the Diverse T Dwarf Population Revealed by WISE
We report the discovery of 87 new T dwarfs uncovered with the Wide-field Infrared Survey Explorer (WISE) and 3 brown dwarfs with extremely red near-infrared colors that exhibit characteristics of both L and T dwarfs. Two of the new T dwarfs are likely binaries with L7 ± 1 primaries and mid-type T secondaries. In addition, our follow-up program has confirmed 10 previously identified T dwarfs and 4 photometrically selected L and T dwarf candidates in the literature. This sample, along with the previous WISE discoveries, triples the number of known brown dwarfs with spectral types later than T5. Using the WISE All-Sky Source Catalog we present updated color-color and color-type diagrams for all the WISE-discovered T and Y dwarfs. Near-infrared spectra of the new discoveries are presented along with spectral classifications. To accommodate later T dwarfs we have modified the integrated flux method of determining spectral indices to instead use the median flux. Furthermore, a newly defined J-narrow index differentiates the early-type Y dwarfs from late-type T dwarfs based on the J-band continuum slope. The K/J indices for this expanded sample show that 32% of late-type T dwarfs have suppressed K-band flux and are blue relative to the spectral standards, while only 11% are redder than the standards. Comparison of the Y/J and K/J index to models suggests diverse atmospheric conditions and supports the possible re-emergence of clouds after the L/T transition. We also discuss peculiar brown dwarfs and candidates that were found not to be substellar, including two young stellar objects and two active galactic nuclei. The substantial increase in the number of known late-type T dwarfs provides a population that will be used to test models of cold atmospheres and star formation. The coolest WISE-discovered brown dwarfs are the closest of their type and will remain the only sample of their kind for many years to come
The Advanced Camera for Surveys General Catalog: Structural Parameters for Approximately Half A Million Galaxies
We present the Advanced Camera for Surveys General Catalog (ACS-GC), a photometric and morphological database using publicly available data obtained with the Advanced Camera for Surveys (ACS) instrument on the Hubble Space Telescope. The goal of the ACS-GC database is to provide a large statistical sample of galaxies with reliable structural and distance measurements to probe the evolution of galaxies over a wide range of look-back times. The ACS-GC includes approximately 470,000 astronomical sources (stars + galaxies) derived from the AEGIS, COSMOS, GEMS, and GOODS surveys. Galapagos was used to construct photometric (SEXTRACTOR) and morphological (GALFIT) catalogs. The analysis assumes a single Sersic model for each object to derive quantitative structural parameters. We include publicly available redshifts from the DEEP2, COMBO-17, TKRS, PEARS, ACES, CFHTLS, and zCOSMOS surveys to supply redshifts (spectroscopic and photometric) for a considerable fraction (similar to 74%) of the imaging sample. The ACS-GC includes color postage stamps, GALFIT residual images, and photometry, structural parameters, and redshifts combined into a single catalog.NASA/ESA GO-10134, GO-09822, GO-09425.01, GO-09583.01, GO-9500NASA NAS 5-26555NSF AST00-71048NASA LTSA NNG04GC89GESO Paranal Observatory LP175.A-0839Astronom
Comparing genetic diversity in three threatened oaks
Genetic diversity is a critical resource for species’ survival during times of environmental change. Conserving and sustainably managing genetic diversity requires understanding the distribution and amount of genetic diversity (in situ and ex situ) across multiple species. This paper focuses on three emblematic and IUCN Red List threatened oaks (Quercus, Fagaceae), a highly speciose tree genus that contains numerous rare species and poses challenges for ex situ conservation. We compare the genetic diversity of three rare oak species-Quercus georgiana, Q. oglethorpensis, and Q. boyntonii-to common oaks; investigate the correlation of range size, population size, and the abiotic environment with genetic diversity within and among populations in situ; and test how well genetic diversity preserved in botanic gardens correlates with geographic range size. Our main findings are: (1) these three rare species generally have lower genetic diversity than more abundant oaks; (2) in some cases, small population size and geographic range correlate with genetic diversity and differentiation; and (3) genetic diversity currently protected in botanic gardens is inadequately predicted by geographic range size and number of samples preserved, suggesting non-random sampling of populations for conservation collections. Our results highlight that most populations of these three rare oaks have managed to avoid severe genetic erosion, but their small size will likely necessitate genetic management going forward
A Study of the Diverse T Dwarf Population Revealed by WISE
We report the discovery of 87 new T dwarfs uncovered with the Wide-field
Infrared Survey Explorer (WISE) and three brown dwarfs with extremely red
near-infrared colors that exhibit characteristics of both L and T dwarfs. Two
of the new T dwarfs are likely binaries with L7+/-1 primaries and mid-type T
secondaries. In addition, our follow-up program has confirmed 10 previously
identified T dwarfs and four photometrically-selected L and T dwarf candidates
in the literature. This sample, along with the previous WISE discoveries,
triples the number of known brown dwarfs with spectral types later than T5.
Using the WISE All-Sky Source Catalog we present updated color-color and
color-type diagrams for all the WISE-discovered T and Y dwarfs. Near-infrared
spectra of the new discoveries are presented, along with spectral
classifications. To accommodate later T dwarfs we have modified the integrated
flux method of determining spectral indices to instead use the median flux.
Furthermore, a newly defined J-narrow index differentiates the early-type Y
dwarfs from late-type T dwarfs based on the J-band continuum slope. The K/J
indices for this expanded sample show that 32% of late-type T dwarfs have
suppressed K-band flux and are blue relative to the spectral standards, while
only 11% are redder than the standards. Comparison of the Y/J and K/J index to
models suggests diverse atmospheric conditions and supports the possible
re-emergence of clouds after the L/T transition. We also discuss peculiar brown
dwarfs and candidates that were found not to be substellar, including two Young
Stellar Objects and two Active Galactic Nuclei. The coolest WISE-discovered
brown dwarfs are the closest of their type and will remain the only sample of
their kind for many years to come.Comment: Accepted to ApJS on 15 January 2013; 99 pages in preprint format, 30
figures, 12 table
Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes an aggressive T-cell malignancy and a variety of inflammatory conditions. The integrated provirus includes a single binding site for the epigenomic insulator, CCCTC-binding protein (CTCF), but its function remains unclear. In the current study, a mutant virus was examined that eliminates the CTCF-binding site. The mutation did not disrupt the kinetics and levels of virus gene expression, or establishment of or reactivation from latency. However, the mutation disrupted the epigenetic barrier function, resulting in enhanced DNA CpG methylation downstream of the CTCF binding site on both strands of the integrated provirus and H3K4Me3, H3K36Me3, and H3K27Me3 chromatin modifications both up- and downstream of the site. A majority of clonal cell lines infected with wild type HTLV-1 exhibited increased plus strand gene expression with CTCF knockdown, while expression in mutant HTLV-1 clonal lines was unaffected. These findings indicate that CTCF binding regulates HTLV-1 gene expression, DNA and histone methylation in an integration site dependent fashion
HCN ice in Titan's high-altitude southern polar cloud
Titan's middle atmosphere is currently experiencing a rapid change of season
after northern spring arrived in 2009. A large cloud was observed for the first
time above Titan's southern pole in May 2012, at an altitude of 300 km. This
altitude previously showed a temperature maximum and condensation was not
expected for any of Titan's atmospheric gases. Here we show that this cloud is
composed of micron-sized hydrogen cyanide (HCN) ice particles. The presence of
HCN particles at this altitude, together with new temperature determinations
from mid-infrared observations, indicate a very dramatic cooling of Titan's
atmosphere inside the winter polar vortex in early 2012. Such a cooling is
completely contrary to previously measured high-altitude warming in the polar
vortex, and temperatures are a hundred degrees colder than predicted by
circulation models. Besides elucidating the nature of Titan's mysterious polar
cloud, these results thus show that post-equinox cooling at the winter pole is
much more efficient than previously thought.Comment: Published in Nature on 2 October 2014. This is the author version,
before final editing by Natur
- …