252 research outputs found
Evolutionary Layout of Graph Transformation Sequences
Graph transformation is used in various different research
areas and has been implemented in several tool environments. However, the layout of graph transformation sequences is often perceived as not optimal and remains to be a difficult task. This is partly due to the slightly different requirements for layouting graph transformation sequences compared to standard graph sequences. In this paper, we clearly define these special requirements and present a layout algorithm which fulfills them. This layout algorithm allows the user to keep track of changes during transformation steps by introducing a concept of node aging and protection of senior node positions in the layout. Furthermore, this layout algorithm introduces a concept of layout patterns. We extended the well-known spring embedder layout algorithm by these new concepts and implemented the new algorithm in AGG, an environment for Attributed Graph Grammars. The layout algorithm has been tested with various
graph grammars. A brief outlook describes how this layout algorithm can also be used for different kinds of graph sequences, e.g. sequences of successively developing class diagrams
Implementing Distributed Controllers for Systems with Priorities
Implementing a component-based system in a distributed way so that it ensures
some global constraints is a challenging problem. We consider here abstract
specifications consisting of a composition of components and a controller given
in the form of a set of interactions and a priority order amongst them. In the
context of distributed systems, such a controller must be executed in a
distributed fashion while still respecting the global constraints imposed by
interactions and priorities.
We present in this paper an implementation of an algorithm that allows a
distributed execution of systems with (binary) interactions and priorities. We
also present a comprehensive simulation analysis that shows how sensitive to
changes our algorithm is, in particular changes related to the degree of
conflict in the system.Comment: In Proceedings FOCLASA 2010, arXiv:1007.499
Greening der Berufe und nachhaltige Arbeitswelt
GREENING DER BERUFE UND NACHHALTIGE ARBEITSWELT
Greening der Berufe und nachhaltige Arbeitswelt / Graf, Susanne (Rights reserved) ( -
Migration, Integration, Asylum: Political Developments in Germany 2018
Der jährlich erscheinende Politikbericht der nationalen Kontaktstelle des Europäischen Migrationsnetzwerks (EMN) beschreibt für knapp ein Dutzend Themenfelder im Bereich der Migrations-, Integrations- und Asylpolitik relevante Entwicklungen im Jahr 2018. Der 15. Politikbericht im Rahmen des Europäischen Migrationsnetzwerks bietet wie gewohnt einen Überblick über die wichtigsten politischen, rechtlichen und institutionellen Entwicklungen des Jahres 2018 in den folgenden Bereichen: Allgemeine politische, rechtliche und institutionelle Struktur, legale Zuwanderung und Mobilität, internationaler Schutz und Asyl, unbegleitete Minderjährige und andere Schutzbedürftige, Integration und Antidiskriminierung, Saatsangehörigkeit und Staatenlosigkeit, irreguläre Migration, Schleusung, Grenzkontrolle und Visapolitik, Rückkehr, Menschenhandel und Migration und Entwicklung. Der EU-weit vergleichende Bericht "Annual Report on Migration and Asylum 2018" fasst wiederum die Ergebnisse von 27 nationalen Politikberichten zusammen und gibt somit einen hilfreichen Überblick zu den EU-weiten Entwicklungen.The annual policy report of the National Contact Point of the European Migration Network (EMN) describes relevant developments in 2018 for almost a dozen topical areas in migration, integration and asylum policy. As usual, the 15th Policy Report of the European Migration Network provides an overview of the most important political, legal and institutional developments in 2018 in the following areas: general political, legal and institutional structure, legal migration and mobility, international protection and asylum, unaccompanied minors and other vulnerable groups, integration and non-discrimination, citizenship and statelessness, irregular migration, migrant smuggling, border control and visa policy, returns, trafficking in human beings, and migration and development. The EU-wide comparative report entitled "Annual Report on Migration and Asylum 2018" summarises the results of 27 national policy reports, and thus provides a helpful overview of EU-wide developments. The comparative annual report is available in three different formats, each in English: the detailed EMN synthesis report, the compact EMN Inform, and the one-page EMN Flash
Bioäpfel - besser und gesünder? Eine Vergleichsstudie mit Standard- und Alternativmethoden der Qualitätserfassung
Die am FiBL auf drei Jahre angelegte Vergleichsstudie fĂĽr Ă„pfel aus integrierter und biologischer Produktion weist nach dem ersten Versuchsjahr signifikante anbaubedingte Unterschiede nach
Retinoic acid pathway activity in wilms tumors and characterization of biological responses in vitro
Background: Wilms tumor (WT) is one of the most common malignancies in childhood. With current therapy protocols up to 90% of patients can be cured, but there is still a need to improve therapy for patients with aggressive WT and to reduce treatment intensity where possible. Prior data suggested a deregulation of the retinoic acid (RA) signaling pathway in high-risk WT, but its mode of action remained unclear. Results: The association of retinoid signaling and clinical parameters could be validated in a large independent tumor set, but its relevance in primary nephrectomy tumors from very young children may be different. Reduced RA pathway activity and MYCN overexpression were found in high risk tumors as opposed to tumors with low/ intermediate risk, suggesting a beneficial impact of RA especially on advanced WT. To search for possible modes of action of retinoids as novel therapeutic options, primary tumor cell cultures were treated in vitro with all-trans-RA (ATRA), 9cis-RA, fenretinide and combinations of retinoids and a histone deacetylase (HDAC) inhibitor. Genes deregulated in high risk tumors showed opposite changes upon treatment suggesting a positive effect of retinoids. 6/7 primary cultures tested reduced proliferation, irrespective of prior RA signaling levels. The only variant culture was derived from mesoblastic nephroma, a distinct childhood kidney neoplasm. Retinoid/HDAC inhibitor combinations provided no synergistic effect. ATRA and 9cis-RA induced morphological changes suggestive of differentiation, while fenretinide induced apoptosis in several cultures tested. Microarray analysis of ATRA treated WT cells revealed differential expression of many genes involved in extracellular matrix formation and osteogenic, neuronal or muscle differentiation. The effects documented appear to be reversible upon drug withdrawal, however. Conclusions: Altered retinoic acid signaling has been validated especially in high risk Wilms tumors. In vitro testing of primary tumor cultures provided clear evidence of a potential utility of retinoids in Wilms tumor treatment based on the analysis of gene expression, proliferation, differentiation and apoptosis
Differentially Testing Soundness and Precision of Program Analyzers
In the last decades, numerous program analyzers have been developed both by
academia and industry. Despite their abundance however, there is currently no
systematic way of comparing the effectiveness of different analyzers on
arbitrary code. In this paper, we present the first automated technique for
differentially testing soundness and precision of program analyzers. We used
our technique to compare six mature, state-of-the art analyzers on tens of
thousands of automatically generated benchmarks. Our technique detected
soundness and precision issues in most analyzers, and we evaluated the
implications of these issues to both designers and users of program analyzers
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