14 research outputs found
Estudio funcional y estructural del transporte de alta afinidad de gaba en sistema nervioso central de rata
No full textCentro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai
Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises
No full textThe amino acid glycine (Gly) serves as a neurotransmitter at excitatory and inhibitory synapses in the mammalian central nervous system. Gly concentrations at post-synaptic neurotransmitter receptors are regulated by Na+/Cl--dependent Gly transporters, which are expressed in neurons and in glial cells. Recent evidence suggests that these transporters are promising targets for the treatment of psychiatric and neurological disorders, such as schizophrenia and pain. Here, recent research on the structure, regulation and pharmacology of mammalian Gly transporters is reviewed
Use of knockout mice reveals involvement of M2-muscarinic receptors in control of the kinetics of acetylcholine release
No full textLoss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors
No full textHeterogeneity of presynpatic muscarinic receptors meiating inhibiiton sympathetic transmitter release: a study with M2- and M4-receptor-deficient mice
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Inactivation of the glycine transporter 1 gene discloses vital role of glial uptake in glyinergic inhibition
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Regional brain uptake of the muscarinic ligand, (18F)FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice
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