Who and where is the renal baroreceptor?: the connexin hypothesis

Gap junctions are emerging as a fundamental mechanism for the control of renin synthesis and release. Connexin40 is prominent in juxtaglomerular cells. When missing, it results in hyperreninemia and hypertension. Schweda et al. offer exciting data demonstrating that connexin45, a connexin with different biophysical properties, can replace connexin40 functions related to the control of renin

Ecology of the Mayan Cichlid, Cichlasoma urophthalmus Günther, in the Alvarado Lagoonal System, Veracruz, Mexico

The Mayan cichlid, Cichlasoma urophthalmus, has a wide distribution in southeastern Mexico where it inhabits rivers and coastal lagoons. In the Alvarado lagoonal system, Veracruz, it is distributed towards the north in Camaronera Lagoon. The Mayan cichlid shows an affinity for oligohaline to mesohaline sites with submerged vegetation, well-oxygenated, deep, and transparent water. The major abundance and biomass of this species was obtained during December to February. The diet of Mayan cichlids consists principally of plant detrital material and algae. Length-frequency distribution shows 2 size classes during both the dry and rainy seasons, corresponding to reproductive fish and young of the year; during the nortes season there is only one modal size class of fish between 60–100 mm SL. Individuals with developed gonads are found throughout the year, although most reproductive adults are found between April and December. The highest Gonadosomatic Index (GSI) values coincided with the peak in reproductive activity between May and July. The fecundity ranged from 1,556–3,348 eggs/female, and there was no relationship between female size and fecundity

Dependence on the Identification of the Scale Energy Parameter Q 2 in the Quark Distribution Functions for a DIS Production of Za

We discuss the Z-production in a DIS (Deep Inelastic Scattering) process e + p → e + Z + X using the Parton Model, within the context of the Standard Model. In contrast with deep inelastic eP-scattering (e + p → e + X), where the choice of Q2, as the transferred momentum squared, is unambiguous; whereas in the case of boson production , the transferred momentum squared, at quark level, depends on the reaction mechanism (where is the EW interaction taking place). We suggest a proposal based on kinematics of the process considered and the usual criterion for Q2 , which leads to a simple and practical prescription to calculate Z-production via ep-DIS. We also introduce different options in order o perform the convolution of the parton distribution functions (PDFs) and the scattering amplitude of he quark processes. Our aim in this work is to analyze and show how large could be the dependence of the total cross section rates on different possible prescriptions used for the identification of the scale energy parameter Q2 . We present results for the total cross section as a function of the total energy √s of the system ep, in the range 300 <√s ≤ 1300 Ge

Manual de Procedimientos administrativos e Indicadores de Gestión

Manual of administrative procedures of the Center of Libraries of the University of Caldas (Manizales, Colombia). Includes several indicators of management as guide for the managers of the dependence

Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determines the pattern of junctional tension in epithelial cell aggregates

We generated a computational approach to analyze the biomechanics of epithelial cell aggregates, either island or stripes or entire monolayers, that combines both vertex and contact-inhibition-of-locomotion models to include both cell-cell and cell-substrate adhesion. Examination of the distribution of cell protrusions (adhesion to the substrate) in the model predicted high order profiles of cell organization that agree with those previously seen experimentally. Cells acquired an asymmetric distribution of basal protrusions, traction forces and apical aspect ratios that decreased when moving from the edge to the island center. Our in silico analysis also showed that tension on cell-cell junctions and apical stress is not homogeneous across the island. Instead, these parameters are higher at the island center and scales up with island size, which we confirmed experimentally using laser ablation assays and immunofluorescence. Without formally being a 3-dimensional model, our approach has the minimal elements necessary to reproduce the distribution of cellular forces and mechanical crosstalk as well as distribution of principal stress in cells within epithelial cell aggregates. By making experimental testable predictions, our approach would benefit the mechanical analysis of epithelial tissues, especially when local changes in cell-cell and/or cell-substrate adhesion drive collective cell behavior.Comment: 39 pages, 8 Figures. Supplementary Information is include

The importance of standard operating procedures in physical fitness assessment: a brief review

Background: Physical fitness status is a key aspect of health and, consequently, it is important to create and adopt appropriate interventions to maintain or improve it, and assess it using valid measures. While in other testing contexts, standard operating procedures (SOPs) are commonly and widely adopted, in physical fitness testing, a variety of unstandardized testing protocols are proposed. Aims: The topic of this review was to evaluate the existing literature on SOPs in physical fitness assessment and to provide guidelines on how SOPs could be created and adopted. Method: The electronic databases PubMed, Web of Science and Scopus were screened and original, peer-reviewed studies that included SOPs, related to physical fitness, were recorded. Results: After the inclusion and exclusion criteria screening, a total of six studies were included and these were critically and narratively analyzed. Conclusions: Standard operating procedures are rarely adopted in the field of physical fitness and a step by step guide has been provided in this manuscript. In the future, it is suggested to follow protocols as a routine, because this is the only way to generalize and contextualize findings

Iodine chemistry in the troposphere and its effect on ozone

Despite the potential influence of iodine chemistry on the oxidizing capacity of the troposphere, reactive iodine distributions and their impact on tropospheric ozone remain almost unexplored aspects of the global atmosphere. Here we present a comprehensive global modelling experiment aimed at estimating lower and upper limits of the inorganic iodine burden and its impact on tropospheric ozone. Two sets of simulations without and with the photolysis of IxOy oxides (i.e. I2O2, I2O3 and I2O4) were conducted to define the range of inorganic iodine loading, partitioning and impact in the troposphere. Our results show that the most abundant daytime iodine species throughout the middle to upper troposphere is atomic iodine, with an annual average tropical abundance of (0.15-0.55) pptv. We propose the existence of a "tropical ring of atomic iodine" that peaks in the tropical upper troposphere (∼11-14 km) at the equator and extends to the sub-tropics (30°N-30°S). Annual average daytime I = IO ratios larger than 3 are modelled within the tropics, reaching ratios up to ∼20 during vigorous uplift events within strong convective regions. We calculate that the integrated contribution of catalytic iodine reactions to the total rate of tropospheric ozone loss (IOx Loss) is 2-5 times larger than the combined bromine and chlorine cycles. When IxOy photolysis is included, IOx Loss represents an upper limit of approximately 27, 14 and 27% of the tropical annual ozone loss for the marine boundary layer (MBL), free troposphere (FT) and upper troposphere (UT), respectively, while the lower limit throughout the tropical troposphere is ∼9 %. Our results indicate that iodine is the second strongest ozone-depleting family throughout the global marine UT and in the tropical MBL. We suggest that (i) iodine sources and its chemistry need to be included in global tropospheric chemistry models, (ii) experimental programs designed to quantify the iodine budget in the troposphere should include a strategy for the measurement of atomic I, and (iii) laboratory programs are needed to characterize the photochemistry of higher iodine oxides to determine their atmospheric fate since they can potentially dominate halogen-catalysed ozone destruction in the troposphere

The effects of advanced maternal age on T- cell subsets at the maternal- fetal interface prior to term labor and in the offspring: a mouse study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155904/1/cei13437.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155904/2/cei13437_am.pd