An Investigation of Some Quinoline and Acridine Derivatives of Possible Therapeutic Value

In this thesis, some new acridine and quinoline ethene derivatives are described, and these compounds will now be considered in detail. Each series has been confined to a separate section for the sake of clarity, and each of these sections is, as far as possible, complete in itself. In Section I, a series of anil coxapounds of 2:8-diamino acridine is discussed, while sections It, III, and IV are concerned chiefly with a series of ethene derivatives prepared from 5-aldehyde acridine. Thus Section II contains pyridine-acridine ethenes of type (a), while Section III deals with analogous quinoline-acridine ethenes of type (b). (a) In Section IV an unsuccessful attempt was made to prepare acridine-acridine ethenes of the following type. The means whereby substituent groups can be introduced into the acridine ring of the ethene compounds prepared are also briefly discussed in this section. In addition to the compounds mentioned above, a few quinoline ethene and anil derivatives of the type studied by Browning and his collaborators have been prepared. The theoretical portion of this thesis has been reserved largely for discussions of a general nature, results of biological tests, and consideration of negative results or cases of especial difficulty arising out of the preparation of the various compounds studied. It contains therefore, little information on the methods of preparation employed, since this is available in extensons in the experimental section, together with any relevant theoretical considerations

Alien Registration- Glen, William A. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/24186/thumbnail.jp

Alien Registration- Glen, William A. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/24186/thumbnail.jp

Some correlations between hypnotic action and chemical constitution

A review of theories of narcosis has been made, and some correlations between constitution and activity have been presented for the aliphatic hypnotics;The close and important relationship of dibenzofuran and its derivatives to morphine has been discussed. The following derivatives to morphine has been discussed. The following derivatives to morphine has been discussed. The following derivatives of dibenzofuran haven been prepared for use in physiological tests: 2-, 3-, and 4-amino-, 2- and 3-hydroxy-dibenzofuran, and 2- and 3-dibenzofurancarboxylic acids;A necessary study of nuclear substitution in dibenzofuran has been made prior to the preparation of derivatives for physiological tests. It has been shown that homonuclear substitution results when 2-discetaminodibenzofuran is brominated or nitrated. Heteronuclear substitution occurs when 3-nitrodibenzofuran is brominated. Both heteronuclear and homonuclear substitution take place when 2-bomodibenzofuran is nitrated;The hydroxydibenzofuran formed by passing resorcinol over heated tungstic oxide has been shown to be 3-hydroxydibenzofuran; and, a low melting isomer formed during nitration of dibenzofuran has been found to consist, in part, of 2-nitrodibenzofuran. The significance of these two facts is discussed with reference to the space formula of dibenzofuran and purported anomalous substitutions

Does the evaluability bias hold when giving to animal charities?

When evaluating a charity by itself, people tend to overweight overhead costs in relation to cost-effectiveness. However, when evaluating charities side by side, they base their donations on cost-effectiveness. I conducted a replication and extension of Caviola et al. (2014; Study 1) using a 3 (High Overhead/Effectiveness, Low Overhead/Effectiveness, Both) x 2 (Humans, Animals) between-subjects design. I found that the overhead ratio is an easier attribute to evaluate than cost-effectiveness in separate evaluation, and, in joint evalution, people allocate decisions based on cost-effectiveness. This effect was observed for human charities, and to a lesser extent, for animal charities

Alien Registration- Glen, William A. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/24186/thumbnail.jp

Alien Registration- Glen, William A. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/24186/thumbnail.jp

Influence of subclinical hypocalcemia on plasma biochemical parameters, liver histologic changes, and common postpartum diseases in dairy cows

Title from PDF of title page (University of Missouri--Columbia, viewed on May 26, 2011).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.Thesis advisor: Dr. James N. Spain.Includes bibliographical references.M.S. University of Missouri--Columbia 2011.We hypothesized that cows with subclinical hypocalcemia at calving would have greater elevations in liver associated biochemical parameters and non-esterified fatty acid (NEFA) concentrations compared to normocalcemic cows. One hundred multiparous Holstein cows were assigned to one of two groups 1) normocalcemic (n=49; ionized calcium [iCa] ! 1.0 mmol/L) or 2) hypocalcemic (n=51; [iCa] [less than 1.0 mmol/L) based on whole blood [iCa] on the day of calving. Blood samples were collected from all cows for measurement of [iCa], NEFA concentrations, and plasma chemistry profiles at days -14, 0 (calving), 3, 7, 14, 21, and 35. On day 0, hypocalcemic cows had lower [iCa] than normocalcemic cows (P [less than] 0.001) and lower total plasma Ca (P [less than] 0.001). Hypocalcemic cows had lower plasma phosphorus concentrations on days 0 (P = 0.002), 7 (P = 0.05), 14 (P = 0.03), and 21 (P = 0.04). Hypocalcemic cows had higher NEFA concentrations on days 0 (P = 0.01) and 21 (P = 0.02). Hypocalcemic cows also tended to have higher NEFA concentrations on day 14 (P = 0.12). Hypocalcemic cows had more lipid in the hepatocytes on day 35 (P = 0.0008). No differences were detected between groups for total or direct bilirubin concentration, gamma glutamyl transferase or aspartate aminotransferase activity (P [greater than] 0.05). These data provide evidence of an association between calcium status at calving, fat mobilization, and liver lipid infiltration

Degree-Day Summation and Hatching of the Forest Tent Caterpillar, \u3ci\u3eMalacosoma Disstria\u3c/i\u3e (Lepidoptera: Lasiocampidae)

(excerpt) The forest tent caterpillar, Malacosoma disstria (Htibner), is a common defoliater of deciduous trees throughout most of the United States and Canada. It is a well known outbreak species, whose populations erupt periodically (every 10 to 16 years) when forest conditions are suitable. Typical outbreaks last three to six years in a given geographic area and then collapse as quickly as they arise. This note documents the relation between forest tent caterpillar egg hatching in the field and heat accumulation (degree-days) leading up to hatch. This information will permit (a) predicting the date on which eggs will hatch by summing degree days during the insect\u27s overwintering period, and (b) comparing with populations in other years and areas. The data came from an outbreak in northern Minnesota that began near International Falls in 1966 and collapsed in 1972 (Witter et al., 1975)