149 research outputs found
Maternal BKİ ve bebeğin yaşı laktasyon dönemindeki kadınların yeme davranışlarını değiştirebilir
Purpose: In lactation, women experience major changes in their lives as new internal and external demands for attention and care for themselves and the baby, also body mass index due to eating behaviours. Our aim was to define relationships between mindful eating and eating behaviours of breastfeeding mothers by baby’s age and maternal BMI. Methods: This cross-sectional study was conducted between October-November 2021 with 302 lactating mothers without chronic disease. Our study was approved by Ethics Committee of the Acibadem Mehmet Ali Aydinlar University. A questionnaire form that examined demographic data and Mindful Eating Questionnaire (MEQ-30) were applied. Anthropometric variables were reported by participants due to Covid-19 pandemic. Results: Mean age of our participants was 30.6±4.2 years. Mothers with obesity had lowest score in MEQ-30 (p<0.001). Lactating mothers who were underweight had highest MEQ-30 score (p<0.001). It was shown that lactating mothers have highest MEQ-30 score in the first 6 months, and MEQ-30 scores decreased as baby grows (p<0.001). Conclusion: Lactation period can be an appropriate time to bring about long-term changes in eating behavior. Healthcare professionals and teams can apply treatments focused on eating behavior and mindful eating for mothers with obesity in terms of their physical and emotional health, especially after the 6th month of breastfeeding.Amaç: Emzirme döneminde kadınlar, kendilerine bakma ve bebeğe bakım verme sürecinde yeni içsel ve dışsal taleplerle baş ederken, ayrıca yeme davranışlarındaki değişiklikler nedeniyle beden kütle indeksi (BKİ) değerinde büyük değişiklikler yaşamaktadır. Bu araştırmadaki amaç, emziren annelerin beden kütle indeksi, yeme farkındalığı ve yeme davranışları arasındaki ilişkileri bebeğin yaşı ve maternal BKİ çerçevesinde değerlendirmektir. Gereç ve Yöntem: Bu kesitsel çalışma, Ekim-Kasım 2021 tarihleri arasında kronik hastalığı olmayan 302 emziren anne ile yapılmıştır. Çalışmamız Acıbadem Mehmet Ali Aydınlar Üniversitesi Etik Kurulu tarafından onaylanmış olup, katılımcılara demografik verileri inceleyen anket formu ve Yeme Farkındalığı Ölçeği (MEQ-30) uygulanmıştır. Covid-19 pandemisi nedeniyle antropometrik veriler katılımcılar tarafından rapor edilmiştir. Bulgular: Katılımcılarımızın yaş ortalaması 30,6±4,2 yıl olarak saptanmıştır. Obezitesi olan anneler yeme farkındalığı ölçeğinden (MEQ-30) diğer gruplara göre daha düşük puan almıştır. (p<0,001). Zayıf anneler en yüksek MEQ-30 skoruna sahip olduğu belirlenmiştir (p<0,001). Emziren annelerin yeme farkındalığı düzeyinin ilk 6 ayda en yüksek olduğu, MEQ30 puanlarının bebek büyüdükçe düştüğü gösterilmiştir (p<0,001). Sonuç: Emzirme dönemi, yeme davranışında uzun vadeli değişiklikler meydana getirmek için uygun bir zaman dilimi olabilmektedir. Sağlık profesyonelleri ve ekipleri, özellikle emzirmenin 6. ayından sonra obezitesi olan annelere fiziksel ve duygusal sağlıkları açısından yeme davranışı ve farkındalığı odaklı tedaviler uygulayarak katkıda bulunabilir
Kronik ve Nükseden Depresyonun Bilinçli Farkındalık Temelli Müdahaleler Çerçevesinden Değerlendirilmesi: Öz-Şefkatin Koruyucu ve Önleyici Etkisi
Bu çalışma ile majör depresyonun tedavisinde kullanımı açısından bilinçli farkındalık temelli müdahaleler açıklanmış ve literatürde bu anlamda yer alan çalışmalar derlenmiştir. Üçüncü kuşak terapi ekolleri içinde yer alan Bilinçli Farkındalık Temelli Bilişsel Terapi (MBCT) programının depresyonun hangi aşamasında kullanıldığı inceleyen çeşitli çalışmalar incelenmiştir. Bilinçli farkındalık temelli müdahalelerin temel çıkış noktasını oluşturan Bilinçli Farkındalık Temelli Stres Azaltma Programı (MBSR) ve bilinçli farkındalık temeline dayanmasının yanında şefkat ve öz-şefkat içeriği ile öne çıkan Bilinçli Farkındalık Temelli Şefkatli Yaşam Programı (MBCL) ve Öz-Şefkatli Farkındalık (MSC) müdahalelerinin incelemeye dahil edildiği bu çalışmada yerli ve yabancı literatür derlenmiştir. Kronik ve nüks eden depresyona karşı müdahale olarak öne çıkan bu yaklaşımların iyileştirici mekanizmalarının üstünde durulmaya çalışılmıştır. Öz-şefkatin psikolojik sağlık açısından koruyucu ve önleyici özelliğinin vurgusunun yapılması ve bu müdahale biçimlerin ana unsurlarından olması açısından ele alınması hedeflenmiştir.In this study, mindfulness-based interventions were explained in terms of their use in the treatment of major depression and studies in the literature in this sense were compiled. Various studies examining the use of the Mindfulness-Based Cognitive Therapy (MBCT) program, which is one of the third generation therapy schools, were examined. Mindfulness-Based Stress Reduction Program (MBSR), which is the main starting point of mindfulness-based interventions, and Mindfulness-Based Compassionate Living Training (MBCL) and Mindful Self-Compassion (MSC) interventions, which stand out with their compassion and self-compassion content as well as being based on mindfulness. In this study, which was included in the review, domestic and foreign literature was compiled. The curative mechanisms of these approaches, which stand out as an intervention against chronic and recurrent depression, have been tried to be emphasized. It is aimed to emphasize the protective and preventive feature of self-compassion in terms of psychological health and to deal with it in terms of being one of the main elements of these intervention forms
Huzurevindeki geriatrik diyabetli bireylerde proprioseptif egzersizin denge ve duyusal fonksiyona etkisi: Randomize kontrollü çalışma
Objective: Diabetes is a chronic disease whose prevalence increases with age and causes severe damages in all systems of the body. The aim of our study was to assess the effects of proprioceptive exercises on balance and sensory function in the geriatric adults with Type 2 diabetes mellitus. Material and Methods: Forty individuals aged 65 and over with Type 2 diabetes mellitus were divided as a study group (n=20) and as a control group (n=20). All patients were evaluated at the baseline and after 8 weeks training. Balance was mea-sured using Berg Balance Scale and Nintendo Wii system. Balance and gait were evaluated by Tinetti Balance and Gait Test. Semmes-Wein-stein monofilament test was used for assessing tactile sensory, diapa-son for vibration and active matching test for joint position sense. Study group received 45 minutes long proprioceptive exercise training 3 times/week for 8 weeks and the control group only received diabetic patient education. Results: Study group demonstrated significant differences in Berg Balance Scale, Wii Fit balance age and Tinetti Balance and Gait Test scores (p<0.05). Vibration perception duration yielded a higher duration in the study group after treatment (p<0.05). Active matching movement and tactile sensory of the sole showed statistically improvement in the study group (p<0.05). Conclusion: Proprioceptive exercises recommended to individuals with geriatric diabetes can be a beneficial approach to increase balance ability to prevent falling and somatosensory loss.Amaç: Diyabet, prevalansı yaşla birlikte artan ve vücudun tüm sistemlerinde ciddi hasarlara neden olan kronik bir hastalıktır. Çalışmamızın amacı, Tip 2 diabetes mellituslu geriatrik erişkinlerde proprioseptif egzersizlerin denge ve duyusal fonksiyon üzerine etkilerini değerlendirmektir. Gereç ve Yöntemler: Tip 2 diabetes mellituslu 65 yaş ve üzeri 40 birey çalışma grubu (n=20) ve kontrol grubu (n=20) olarak ayrıldı. Tüm hastalar başlangıçta ve 8 haftalık eğitimden sonra değerlendirildi. Denge, Berg Denge Ölçeği ve Nintendo Wii sistemi kullanılarak ölçüldü. Denge ve yürüme, Tinetti Denge ve Yürüyüş Testi ile değerlendirildi. Dokunma duyusunu değerlendirmek için SemmesWeinstein monofilament testi, titreşim için diyapazon ve eklem pozisyon duyusu için aktif eşleştirme testi kullanıldı. Çalışma grubu 8 hafta boyunca haftada 3 kez 45 dk’lık proprioseptif egzersiz eğitimi aldı ve kontrol grubuna sadece diyabetik hasta eğitimi verildi. Bulgular: Çalışma grubu, Berg Denge Ölçeği, Wii Fit denge yaşı ve Tinetti Denge ve Yürüyüş Testi puanlarında anlamlı farklılıklar gösterdi (p<0,05). Titreşim algılama süresi, tedaviden sonra çalışma grubunda daha yüksek bir süre ile sonuçlandı (p<0,05). Aktif eşleştirme hareketi ve tabanın taktil duyusu, çalışma grubunda istatistiksel olarak gelişme gösterdi (p<0,05). Sonuç: Geriatrik diyabetli bireylere önerilen proprioseptif egzersizler, düşme ve somatosensoriyel kaybı önlemek için denge becerisini artırmada faydalı bir yaklaşım olabilir
Respiratory muscle strengths and its association with body composition and functional exercise capacity in non-obese young adults
Background. The assessment of cardiopulmonary problems, exercise capacity, and inspiratory and expiratory muscle strength all depend on body composition, which is a crucial factor in determining human health. Objectives. The present study aimed to examine the effect of body composition and functional exercise capacity on respiratory muscle strength in young healthy adults. Material and methods. In the prospective study, sixty individuals aged between 18-25 years of age who were non-obese were evaluated in terms of body composition by body mass index, respiratory muscle strength by mouth pressure threshold and functional exercise capacities by six minute walking test and sit to stand test. Also, sociodemographic characteristics such as age, gender, education level, height and weight of the participants were recorded. Results. The relationship between body density (BD) parameters and inspiratory muscle strength was found to be moderate (r = 0.394, p 0.05). Conclusions. Present study showed a significant correlation between body density and inspiratory and expiratory respiratory muscle strength. However, no correlation was found between body composition and functional exercise capacity and respiratory muscle strength. Body density increment will affect respiratory muscle strength negatively
QbD Implementation in Biotechnological Product Development Studies
Biotechnological drug development is an extensive area still growing and coming into prominence day by day. Since biotechnological product manufacturing is irreversible, highly expensive, and contains so many critical parameters throughout the process, quality control tests applied to the finished product become inefficacious; therefore, maintaining predefined quality is crucial. Quality by Design (QbD), a systematic approach, is designing and optimizing of formulation and production processes in order to provide a predefined product quality by following a risk and scientific-based path. Determining the critical variables for biotechnological products and their manufacturing via risk assessment is the first and most vital stage of QbD approach, before exploring the multivariate relations among the independent and dependent critical variables by mathematical modeling with the assistive technologies. Response Surface Method (RSM), Artificial Neural Network (ANN), and Genetic Algorithm (GA) are some of the assistive technologies used to perform mathematical modeling. After modeling, additional knowledge is vested and this provides the chance to find a range in which the product quality is always ensured, called as “Design space”. So, product quality is procured all along the process by keeping the critical variables under control with less effort, money, and mistakes
Evaluation of Serum and Salivary Lipid Peroxidation Levels According to Periodontitis Type
Aim: In this study, we aimed to investigate the role of malondialdehyde (MDA) in the pathophysiology of periodontitis by examining serum and salivary MDA levels in patients with advanced periodontitis and healthy individuals according to the periodontal disease classification revised in the workshop held by the American Association of Chartered Epidemiologists and the European Federation in 2017.
Methods: The study was designed as a cross-sectional study, and a total of 37 patients who applied to Karadeniz Technical University Faculty of Dentistry, Department of Periodontology, in 2022 for periodontal disorders or controls were included. A total of 37 individuals, aged 25-48 years, with stage III grade C periodontitis (Group 1; 13 patients), stage IV grade C periodontitis (Group 2; 12 patients), and a periodontally healthy group (Group 3; 12 individuals) were included in the study. After the demographic characteristics and body mass index (BMI) data were obtained, the clinical periodontal parameters and serum and saliva MDA values of the individuals were measured. All the obtained data were statistically analyzed.
Results: Although BMI was lower and education level was higher in the controls (p<0.034), other demographic characteristics did not differ between the groups. When the clinical periodontal parameters were examined, the lowest values were observed in the controls, whereas the highest values were observed in stage IV. The difference between all three groups was statistically significant (p=0.000). Although serum MDA levels did not differ between the groups, the highest MDA level was observed in stage III, and the lowest MDA level was observed in the controls. In addition, salivary MDA levels did not differ between the groups, with the highest MDA level observed in stage III and the lowest MDA level observed in stage IV.
Conclusion: The findings of our study showed that systemic and local lipid peroxidation levels increased/decreased in individuals with advanced periodontitis compared with the periodontal healthy group, but this change was not statistically significant. Our findings suggest that different oxidative stress mechanisms may also be involved in advanced periodontitis
Yol Verme Davranışı: Sürücülerin Yol Verme Davranışını Anlamak Üzerine Karma Yöntemli Bir Çalışma
Sürücülerin yayalara yol verme davranışını incelemek üzere saha gözlemleri ve yarı-yapılandırılmış mülakatlar yapılmıştır.
1140 araç-yaya gözlemi sonucunda yapılan Cramer’in V katsayısı ve lojistik regresyon analizleri, sürücü cinsiyeti ve yaya yaşı
ile yol verme davranışı arasında anlamlı bir ilişki olduğunu göstermiştir. Yaş ve cinsiyetin yanı sıra, sürücü-yaya ilişkisinin
doğasını anlamak adına yol özelliklerinin bu ilişkiye etkisi de incelenmiştir. Mülakatlar ise tematik analiz yöntemi ile
incelenmiş ve katılımcıların yol verme davranışı ile ilgili düşünceleri 4 tema altında toplanmıştır. Bunlar; "Karşılaşma yerleri",
"Kurallara olan güven", "Yol verme davranışını etkileyen faktörler" ve "Geleceğe yönelik çözümler" olarak belirlenmiştir. Hem
saha gözlemleri hem de mülakatlar sürücü-yaya ilişkisinin trafik güvenliği ile ilgili önemli bir faktör olduğunu göstermiştir
Social Representations of Working Mothers in Social Media in Turkey
İş gücüne katılan kadın sayısının artmasına karşın toplumsal cinsiyet rolleriyle ilgili beklentiler geçerliliğinikoruyabilmektedir. Mevcut çalışma, Türkiye'deki sosyal medya kullanıcılarının çalışan annelere ilişkinsosyal temsillerini incelemeyi hedeflemiştir. Bu amaçla, bir sosyal site olan Eşi Sözlük sitesinden tek sayılıveriler seçilerek çalışan annelere ilişkin 60 girdi iki araştırmacı tarafından anlamlı söz öbekleri tek tekdeğerlendirilerek kodlanmıştır. Konvansiyonel içerik analizine göre, söz öbeklerindeki ortak örüntülerinbir araya getirilmesi sonucunda 6 adet üst tematik birim ortaya çıkmıştır. Bunlar: i) çalışan anneler ile ilgiligenel bakış açısını, ii) çalışan annenin çocuğun gelişimine etkisini, iii) çalışan anne ile ilgili çocuğun bakışaçısını, iv) çalışan anne olmak ile ilgili annelerin bakış açılarını, v) çalışan annenin sosyal destekkaynaklarını ve vi) çalışan annenin meslek tipi ve mesleğinin içeriklerini yansıtmaktadır. Tematikbirimlerin içeriğine bakıldığında toplumsal cinsiyet rollerinin çalışan anne ile ilgili sosyal temsiller üzerineetkisi görülmektedir. Bulguların, Türkiye toplumundaki çalışan anne temsiline dair önemli bilgiler verdiğidüşünülmektedir.Despite the increased rate of women's labor force participation, expectations from women related with gender roles are still common. The current study aims to investigate social representations of social media users toward working mothers in Turkey. For this purpose, by selecting odd-numbered data from a social site called as Ekşi Sözlük, all meaningful phrases in 60 entries were evaluated by two researchers. In accordance with conventional content analysis, common patterns in the phrases were gathered, and six thematic codes were constructed: i) general perspectives of people about working mothers, ii) the impacts of working mothers on their children, iii) children’s perspective about their working mothers, iv) mothers’ perspectives related to being a working mother, v) social support to working mothers, and vi) the occupation types of working mothers and the content of occupations. Concerning thematic units, the effects of gender roles on the social representations of working mother were shown. These findings were considered as valuable information with regards to the social representations of working mothers in Turkish society
The effect of teff seed on hematological findings and anthropometric measurements
Background: The low incidence of diseases such as celiac, anemia, osteoporosis, and obesity in Ethiopia has aroused interest in the study of teff. The primary objective of this study was to determine the effect of regular consumption of teff seeds on hematological findings and anthropometric measurements in overweight and obese individuals. The secondary objective was to compare these effects of teff seeds with the Mediterranean diet. Methods: In our study, planned as a cohort study, 28 participants followed the teff seed-containing diet (n=14) and the Mediterranean diet (n=14) for 3 months. To determine nutritional status, a 72-h recall was taken. Anthropometric measurements and hematological findings were recorded at the beginning and end of the study. Results: There was a significant decrease in fasting blood glucose, cholesterol, LDL, and HDL levels in the teff group (p<0.05). The increase in total protein levels in the teff group was significantly higher than in the Mediterranean diet group (p=0.05). With increased intake of carbohydrates (g) in the teff group, fasting blood glucose levels decreased significantly. There was no significant difference between the two groups regarding anthropometric measurements. Conclusion: It has been found that the teff seed has no predominance over anthropometric measurements, as compared to the Mediterranean diet, and that it is more effective in improving hematological findings related to obesity. There is a need for more comprehensive studies that also address physical activity, the different types of teff seeds available, and include increased participant numbers.Institute of Health Mega Research Project of Jamma Universit
Analytical Validation of a Spiral Microfluidic Chip with Hydrofoil-Shaped Pillars for the Enrichment of Circulating Tumor Cells
The isolation of circulating tumor cells (CTCs) from peripheral blood with high efficiency remains a challenge hindering the utilization of CTC enrichment methods in clinical practice. Here, we propose a microfluidic channel design for the size-based hydrodynamic enrichment of CTCs from blood in an epitope-independent and high-throughput manner. The microfluidic channel comprises a spiral-shaped part followed by a widening part, incorporating successive streamlined pillars, that improves the enrichment efficiency. The design was tested against two benchmark designs, a spiral microfluidic channel and a spiral microfluidic channel followed by a widening channel without the hydrofoils, by processing 5 mL of healthy blood samples spiked with 100 MCF-7 cells. The results proved that the design with hydrofoil-shaped pillars perform significantly better in terms of recovery (recovery rate of 67.9% compared to 23.6% in spiral and 56.7% in spiral with widening section), at a cost of slightly lower white blood cell (WBC) depletion (depletion rate of 94.2% compared to 98.6% in spiral and 94.2% in spiral with widening section), at 1500 µL/min flow rate. For analytical validation, the design was further tested with A549, SKOV-3, and BT-474 cell lines, yielding recovery rates of 62.3 ± 8.4%, 71.0 ± 6.5%, and 82.9 ± 9.9%, respectively. The results are consistent with the size and deformability variation in the respective cell lines, where the increasing size and decreasing deformability affect the recovery rate in a positive manner. The analysis before and after the microfluidic chip process showed that the process does not affect cell viability
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