DEMONSTRATION OF PROTEIN HYDROGEN BONDING NETWORK APPLICATION TO MICROELECTRONICS

Model of hydrogen bonding networks in active site of b-lactamase during the last intermediate EY of acylenzyme reaction semicycle is presented. The I-V characteristics of each hydrogen bond are calculated following Marcus theory and theory of protein electrostatics. Simulations showed that HBN characteristics are similar to the characteristics of microelectronic devices such as amplifier, signal modulator, triangular pulse source. The results demonstrated the analogy of HBNs in the active site of β-lactamase protein to microelectronic integrated circuit with multiple outputs each with different characteristics

Hydrogen bonding network emulating frequency driven source of triangular pulses

A three output microelectronic circuit functionally equivalent to a hydrogen bonding network is modeled. Proton transfer characteristics of each hydrogen bond of the network are emulated by block-elements in the microelectronic circuit with their respective l-V characteristics. These characteristics are coded in Matlab where the dynamic and static analyses are carried out. The results imply that in static mode the functionally analogous circuit operates as a current source or an amplifier. In dynamic mode the circuit behaves as a voltage driven triangular pulse signal source. The simulations show that the generated pulses at the three circuit outputs have different frequency, amplitude, and width