29 research outputs found

    Modules of generalized fractions, direct systems of determinantal maps and other topics in commutative algebra

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    SIGLEAvailable from British Library Document Supply Centre- DSC:D71691/87 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    Comparison and Assessment of Epidemic Models

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    Towards an overheating risk tool for building design

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    PurposeThe work set out to design and develop an overheating risk tool using the UKCP09 climate projections that is compatible with building performance simulation software. The aim of the tool is to exploit the Weather Generator and give a reasonably accurate assessment of a building's performance in future climates, without adding significant time, cost or complexity to the design team's work.Methodology/approachBecause simulating every possible future climate is impracticable, the approach adopted was to use principal component analysis to give a statistically rigorous simplification of the climate projections. The perceptions and requirements of potential users were assessed through surveys, interviews and focus groups.FindingsIt is possible to convert a single dynamic simulation output into many hundreds of simulation results at hourly resolution for equally probable climates, giving a population of outcomes for the performance of a specific building in a future climate, thus helping the user choose adaptations that might reduce the risk of overheating. The tool outputs can be delivered as a probabilistic overheating curve and feed into a risk management matrix. Professionals recognized the need to quantify overheating risk, particularly for non‐domestic buildings, and were concerned about the ease of incorporating the UKCP09 projections into this process. The new tool has the potential to meet these concerns.Originality/valueThe paper is the first attempt to link UKCP09 climate projections and building performance simulation software in this way and the work offers the potential for design practitioners to use the tool to quickly assess the risk of overheating in their designs and adapt them accordingly.</jats:sec

    New model diagnostics for spatio-temporal systems in epidemiology and ecology

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    A cardinal challenge in epidemiological and ecological modelling is to develop effective and easily deployed tools for model assessment. The availability of such methods would greatly improve understanding, prediction and management of disease and ecosystems. Conventional Bayesian model assessment tools such as Bayes factors and the deviance information criterion (DIC) are natural candidates but suffer from important limitations because of their sensitivity and complexity. Posterior predictive checks, which use summary statistics of the observed process simulated from competing models, can provide a measure of model fit but appropriate statistics can be difficult to identify. Here, we develop a novel approach for diagnosing mis-specifications of a general spatio-temporal transmission model by embedding classical ideas within a Bayesian analysis. Specifically, by proposing suitably designed non-centred parametrization schemes, we construct latent residuals whose sampling properties are known given the model specification and which can be used to measure overall fit and to elicit evidence of the nature of mis-specifications of spatial and temporal processes included in the model. This model assessment approach can readily be implemented as an addendum to standard estimation algorithms for sampling from the posterior distributions, for example Markov chain Monte Carlo. The proposed methodology is first tested using simulated data and subsequently applied to data describing the spread of Heracleum mantegazzianum (giant hogweed) across Great Britain over a 30-year period. The proposed methods are compared with alternative techniques including posterior predictive checking and the DIC. Results show that the proposed diagnostic tools are effective in assessing competing stochastic spatio-temporal transmission models and may offer improvements in power to detect model mis-specifications. Moreover, the latent-residual framework introduced here extends readily to a broad range of ecological and epidemiological models

    Bayesian Inference for Stochastic epidemics in closed populations.

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    Abstract: We consider continuous-time stochastic compartmental models that can be applied in veterinary epidemiology to model the within-herd dynamics of infectious diseases. We focus on an extension of Markovian epidemic models, allowing the infectious period of an individual to follow a Weibull distribution, resulting in a more exible model for many diseases. Following a Bayesian approach we show how approximation methods can be applied to design efcient MCMC algorithms with favourable mixing properties for tting non-Markovian models to partial observations of epidemic processes. The methodology is used to analyse real data concerning a smallpox outbreak in a human population, and a simulation study is conducted to assess the effects of the frequency and accuracy of diagnostic tests on the information yielded on the epidemic process

    Bayesian Inference for Stochastic epidemics in closed populations.

    No full text
    Abstract: We consider continuous-time stochastic compartmental models that can be applied in veterinary epidemiology to model the within-herd dynamics of infectious diseases. We focus on an extension of Markovian epidemic models, allowing the infectious period of an individual to follow a Weibull distribution, resulting in a more exible model for many diseases. Following a Bayesian approach we show how approximation methods can be applied to design efcient MCMC algorithms with favourable mixing properties for tting non-Markovian models to partial observations of epidemic processes. The methodology is used to analyse real data concerning a smallpox outbreak in a human population, and a simulation study is conducted to assess the effects of the frequency and accuracy of diagnostic tests on the information yielded on the epidemic process
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