Introducing new molecular technologies into routine clinical cancer care: is there an impact on the treatment of breast cancer?

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Combining mitigation treatments against biases in personalized rankings: Use case on item popularity

Historical interactions leveraged by recommender systems are often non-uniformly distributed across items. Though they are of interest for consumers, certain items end up therefore being biasedly under-recommended. Existing treatments for mitigating these biases act at a single step of the pipeline (either pre-, in-, or post-processing), and it remains unanswered whether simultaneously introducing treatments throughout the pipeline leads to a better mitigation. In this paper, we analyze the impact of bias treatments along the steps of the pipeline under a use case on popularity bias. Experiments show that, with small losses in accuracy, the combination of treatments leads to better trade-offs than treatments applied separately. Our findings call for treatments rooting out bias at different steps simultaneously

Engineering exotic phases for topologically-protected quantum computation by emulating quantum dimer models

We use a nonperturbative extended contractor renormalization (ENCORE) method for engineering quantum devices for the implementation of topologically protected quantum bits described by an effective quantum dimer model on the triangular lattice. By tuning the couplings of the device, topological protection might be achieved if the ratio between effective two-dimer interactions and flip amplitudes lies in the liquid phase of the phase diagram of the quantum dimer model. For a proposal based on a quantum Josephson junction array [L. B. Ioffe {\it et al.}, Nature (London) {\bf 415}, 503 (2002)] our results show that optimal operational temperatures below 1 mK can only be obtained if extra interactions and dimer flips, which are not present in the standard quantum dimer model and involve three or four dimers, are included. It is unclear if these extra terms in the quantum dimer Hamiltonian destroy the liquid phase needed for quantum computation. Minimizing the effects of multi-dimer terms would require energy scales in the nano-Kelvin regime. An alternative implementation based on cold atomic or molecular gases loaded into optical lattices is also discussed, and it is shown that the small energy scales involved--implying long operational times--make such a device impractical. Given the many orders of magnitude between bare couplings in devices, and the topological gap, the realization of topological phases in quantum devices requires careful engineering and large bare interaction scales.Comment: 12 pages, 10 figure

How Much Longer Will it Take? A Ten-year Review of the Implementation of United Nations General Assembly Resolutions 61/105, 64/72 and 66/68 on the Management of Bottom Fisheries in Areas Beyond National Jurisdiction

The United Nations General Assembly (UNGA) in 2002 adopted the first in a series of resolutions regarding the conservation of biodiversity in the deep sea. Prompted by seriousconcerns raised by scientists, non-governmental organizations (NGOs) and numerous States,these resolutions progressively committed States to act both individually and through regional fishery management organizations (RFMOs) to either manage bottom fisheries in areas beyond national jurisdiction to prevent significant adverse impacts on deep-sea species, ecosystems and biodiversity or else prohibit bottom fishing from taking place.Ten years have passed since the adoption of resolution 61/105 in 2006, calling on States to take a set of specific actions to manage bottom fisheries in areas beyond national jurisdiction to protect vulnerable marine ecosystems (VMEs) from the adverse impacts of bottom fishing and ensure the sustainability of deep-sea fish stocks. Despite the considerable progress by some RFMOs, there remain significant gaps in the implementation of key elements and commitments in the resolutions. The Deep Sea Conservation Coalition (DSCC) has prepared this report to assist the UNGA in its review in 2016 and to address the following question: How effectively have the resolutions been implemented

Spatial dependence of the Star Formation History in the Central Regions of the Fornax Dwarf Spheroidal Galaxy

We present the Star Formation History (SFH) and the age-metallicity relation (AMR) in three fields of the Fornax dwarf spheroidal galaxy. They sample a region spanning from the centre of the galaxy to beyond one core radius, which allows studying galactocentric gradients. In all the cases, we found stars as old as 12 Gyr, together with intermediate-age and young stellar populations. The last star formation events, as young as 1 Gyr old, are mainly located in the central region, which may indicate that the gas reservoir in the outer parts of the galaxy would have been exhausted earlier than in the centre or removed by tidal interactions. The AMR is smoothly increasing in the three analyzed regions and similar to each other, indicating that no significant metallicity gradient is apparent within and around the core radius of Fornax. No significant traces of global UV-reionization or local SNe feedback are appreciated in the early SFH of Fornax. Our study is based on FORS1@VLT photometry as deep as I~24.5 and the IAC-star/IAC-pop/MinnIAC suite of codes for the determination of the SFH in resolved stellar populations.Comment: 13 pages, 8 figures, 4 table

Supertertiary protein structure affects an allosteric network

The notion that protein function is allosterically regulated by structural or dynamic changes in proteins has been extensively investigated in several protein domains in isolation. In particular, PDZ domains have represented a paradigm for these studies, despite providing conflicting results. Furthermore, it is still unknown how the association between protein domains in supramodules, consitituting so-called supertertiary structures, affects allosteric networks. Here, we experimentally mapped the allosteric network in a PDZ:ligand complex, both in isolation and in the context of a supramodular structure, and show that allosteric networks in a PDZ domain are highly dependent on the supertertiary structure in which they are present. This striking sensitivity of allosteric networks to the presence of adjacent protein domains is likely a common property of supertertiary structures in proteins. Our findings have general implications for prediction of allosteric networks from primary and tertiary structures and for quantitative descriptions of allostery

The kinetics of folding of the NSH2 domain from p85

SH2 domains are protein domains that mediate protein-protein interaction through the recognition and binding of specific sequences containing phosphorylated tyrosines. The p85 protein is the regulatory subunit of the heterodimeric enzyme PI3K, an important enzyme involved in several molecular pathways. In this work we characterize the folding kinetics of the NSH2 domain of p85. Our data clearly reveal peculiar folding kinetics, characterized by an apparent mismatch between the observed folding and unfolding kinetics. Taking advantage of double mixing stopped flow experiments and site directed mutagenesis we demonstrate that such behavior is due to the cis/trans isomerization of the peptide bond between D73 and P74, being in a cis conformation in the native protein. Our data are discussed in comparison with previous works on the folding of other SH2 domains