Il bilancio integrato per le PMI

Accanto ai capitali finanziario e produttivo, ogni impresa fonda il proprio business e il proprio successo anche su risorse intangibili, quali il capitale intellettuale, il capitale umano, il capitale sociale e relazionale ed il capitale naturale. Il tradizionale bilancio economico-finanziario, però, non è adatto a valutare e rappresentare tali risorse, poiché è stato concepito con riferimento ad un’economia industriale fondata pressoché esclusivamente su capitali tangibili; pertanto, anche avuto riguardo alla realtà delle PMI, si rende oggi necessario introdurre nuovi strumenti e nuovi indicatori per la misurazione e la rendicontazione, che siano in grado di cogliere e valorizzare anche le componenti immateriali del capitale aziendale. In questo contesto, il bilancio integrato si pone come una forma evoluta di comunicazione aziendale, finalizzata ad illustrare come strategia, governance, modello di business, rapporti con gli stakeholder, performance passate e prospettive future, rischi e opportunità consentano anche ad un’impresa di piccole e medie dimensioni di creare valore nel breve, medio e lungo termine

SystemC/TLM controller for efficient NAND flash management in electronic musical instruments

The design of an efficient memory subsystem is a fundamentally challenging task in the design of electronic equipment. The storage hierarchy chosen for a particular design has a significant impact on the overall performance and cost. Flash memory often contains the boot code, operating system kernel, device drivers, middleware, and other application-specific software that can result in megabytes of non-volatile stored data. To maximize the performance, data are moved from non-volatile memory to faster SDRAM (synchronous dynamic random-access memory). Non-volatile memory technologies reach a performance level close to that of dynamic RAMs with the additional benefit of persistent data storage. When cost is critical, an approach where the data are managed directly from non-volatile memory can be used. In this case the non-volatile memory subsystem is constantly accessed to retrieve data. The deep understanding of the system architecture is critical to identify any factor that affects memory performance and the resulting system performance; particularly in specific applications with stricter requests like streaming audio when more than one hundred data streams must be handled in a real-time environment and sound must be generated with a total latency of a few milliseconds. This article reports the development of the system-level model of a controller in a SystemC simulation environment capable of optimizing the use of NAND type flash memories for storage and playback of audio samples in real-time music applications, with the aim of reducing the quantity of the system SDRAM memory, thus lowering the cost of the final product, while still providing the most high-fidelity sound experience

Latest Insights and Therapeutic Advances in Myelodysplastic Neoplasms

simple summary several recent studies have demonstrated encouraging results in treating patients with myelodysplastic syndromes/neoplasms (MDSs). this review focuses on the latest conceptual and therapeutic advances in the management of adults with MDS, addressing diagnostic principles, classification updates, and prognostic stratification systems, as well as improvements in clinical approaches that provide significant benefits through novel treatments, which may, in turn, represent a valuable basis for developing future clinical trials. abstract myelodysplastic syndromes/neoplasms (MDSs) encompass a range of hematopoietic malignancies, commonly affecting elderly individuals. molecular alterations in the hematopoietic stem cell compartment drive disease pathogenesis. recent advancements in genomic profiling have provided valuable insights into the biological underpinnings of MDSs and have expanded therapeutic options, particularly for specific molecularly defined subgroups. this review highlights the diagnostic principles, classification updates, prognostic stratification systems, and novel treatments, which could inform future clinical trials and enhance the management of adult MDS patients, particularly for specific molecularly defined subgroups

Un mueble para Amancio. Experiencia de articulación entre cátedras de las Facultades de Arquitectura de la FAUD-UNC (Córdoba) y de Diseño de la FAUD-UNMDP (Mar del Plata)

Trabajo presentado en el 3º Congreso Virtual "Las Nuevas Tecnologías, su influencia en la formación y Producción Disciplinar. San Miguel de Tucumán, 2015El trabajo, consistió en el desarrollo de un ejercicio de diseño en dos etapas: una de Workshop interdisciplinario con alumnos de Diseño Industrial y de Arquitectura de las Facultades de Córdoba y Mar del Plata, en la ciudad de Mar del Plata, y otra donde los alumnos trabajan de modo individual en sus facultades en formato de esquicio continuo.El objetivo fue trabajar en un mueble para una obra icónica de la arquitectura moderna, concretamente en el re-diseño del equipamiento central de la Casa sobre el Arroyo, para fortalecer su relación e interpretación, de manera integrada con las tipologías que el alumno vino trabajando en otras disciplinas como tecnologías, morfologías, etc., fundamentado en los nuevos modos de habitar, basados en nuevas relaciones sociales y familiares.Para aquellos que no pudieron visitar personalmente la casa se compartieron fotos, videos y una plataforma de recorrido virtual 3D por la casa, además de trabajar con proyección de documentales sobre la obra de Amancio Williams.El material producido en la primera etapa fue digitalizado por el equipo de cátedra y subido a una plataforma virtual, http://unmuebleparaamancio.jimdo.com, a disposición de los alumnos para fortalecer el proceso de retroalimentación y de construcción colectiva del conocimiento, los avances sucesivos de los estudiantes se compartieron semana a semana en una suerte de extensión virtual del taller.En la siguiente etapa se realizó una actividad de intercambio y cierre a través de videoconferencia para evaluar y compartir los resultados a los que cada alumno de las diferentes disciplinas arribó.https://congresoartes.wordpress.com/ponentes/diseno/veron-maria-jose/Fil: Verón, María José. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Gallardo, Jonny. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Figueroa, María. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Liberati, Florencia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Dunkler, Lucas. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Baldo, Anahí. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Gianfelici, Marco. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Machuca, Ariel. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Mengo, Gabriela. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Iussa, Emiliano. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: De Battisti, Eliana. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Apaza Yanarico, David. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaDiseño Arquitectónic

RNAseq unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications

Despite therapeutic improvements, a sizable number of T-cell acute lymphoblastic leukemia patients still witness a poor outcome. To unravel the genomic background associated with refractoriness, we evaluated the transcriptome of 19 refractory/early relapsed T-cell acute lymphoblastic leukemia cases (discovery cohort) on diagnostic material by performing RNA-sequencing. The incidence and prognostic impact of the most frequently mutated pathways were validated on diagnostic samples of an independent cohort of 49 cases (validation cohort), including refractory, relapsed and responsive cases, by Sanger sequencing on genomic DNA. Combined gene expression and fusion transcript analyses in the discovery cohort revealed the presence of known oncogenes and identified novel rearrangements inducing overexpression, as well as inactivation of tumor suppressor genes. Mutation analysis identified JAK/STAT and RAS/PTEN as the most commonly disrupted pathways in chemorefractory/early relapsed patients, frequently in association with NOTCH1/FBXW7 mutations. Validation analysis on the validation cohort documented a significantly higher risk of relapse, inferior overall survival, disease-free survival and event-free survival in JAK/STAT and RAS/PTEN altered patients. Conversely, a significantly better survival was observed in patients harboring only NOTCH1/FBXW7 mutations: this favorable prognostic effect was abrogated by the presence of concomitant mutations. Preliminary in vitro assays on primary cells documented sensitivity to specific inhibitors. These data document the negative prognostic impact of JAK/STAT and RAS/PTEN mutations in T-cell acute lymphoblastic leukemia and suggest the potential clinical application of JAK and PI3K/mTOR inhibitors in patients harboring mutations in these pathways

Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes

To shed light into the molecular bases of B-lineage acute lymphoblastic leukemia lacking known fusion transcripts, i.e. BCR-ABL1, ETV6-RUNX1, E2A-PBX1, and MLL rearrangements (B-NEG ALL) and the differences between children, adolescents/young adults (AYA) and adults, we analyzed 168 B-NEG ALLs by genome-wide technologies. This approach showed that B-NEG cases carry 10.5 mutations and 9.1 copy-number aberrations/sample. The most frequently mutated druggable pathways were those pertaining to RAS/RTK (26.8%) and JAK/STAT (12.5%) signaling. In particular, FLT3 and JAK/STAT mutations were detected mainly in AYA and adults, while KRAS and NRAS mutations were more frequent in children. RAS/RTK mutations negatively affected the outcome of AYA and adults, but not that of children. Furthermore, adult B-NEG ALL carrying JAK/STAT mutations had a shorter survival. In vitro experiments showed that FLT3 inhibitors reduced significantly the proliferation of FLT3-mutated primary B-NEG ALL cells. Likewise, PI3K/mTOR inhibitors reduced the proliferation of primary cells harboring RAS and IL7R mutations. These results refine the genetic landscape of B-NEG ALL and suggest that the different distribution of lesions and their prognostic impact might sustain the diverse outcome between children, adults and partly AYA - whose genomic scenario is similar to adults - and open the way to targeted therapeutic strategies

High-Resolution Photoemission Study of Neutron-Induced Defects in Amorphous Hydrogenated Silicon Devices

In this paper, by means of high-resolution photoemission, soft X-ray absorption and atomic force microscopy, we investigate, for the first time, the mechanisms of damaging, induced by neutron source, and recovering (after annealing) of p-i-n detector devices based on hydrogenated amorphous silicon (a-Si:H). This investigation will be performed by mean of high-resolution photoemission, soft X-Ray absorption and atomic force microscopy. Due to dangling bonds, the amorphous silicon is a highly defective material. However, by hydrogenation it is possible to reduce the density of the defect by several orders of magnitude, using hydrogenation and this will allow its usage in radiation detector devices. The investigation of the damage induced by exposure to high energy irradiation and its microscopic origin is fundamental since the amount of defects determine the electronic properties of the a-Si:H. The comparison of the spectroscopic results on bare and irradiated samples shows an increased degree of disorder and a strong reduction of the Si-H bonds after irradiation. After annealing we observe a partial recovering of the Si-H bonds, reducing the disorder in the Si (possibly due to the lowering of the radiation-induced dangling bonds). Moreover, effects in the uppermost coating are also observed by spectroscopies