The effect of Halcoholic extract of celery leaves on the delivery rate (fertilization and stillbirths), the number, weight and sex ratio of rat off spring

Objectives: Infertility is one of the most common health problems in the world. Different plants are used in traditional medicine to treat infertility. Celery is rich in flavonoids and vitamins E and C. The present study investigated the effect of hydroalcoholic extract of celery leaves on the delivery rate, number, weight and sex ratio of rat offspring. Materials and Methods: In this experimental study, 45 Wistar rats were randomly divided into three groups of fifteen (five male and 10 female rats per group). The control group received 1 ml of distilled water, and experimental groups received respectively doses of 100 and 200 mg/kg/BW celery extract for five weeks by gavage. During the fifth week each male rat was mated with two female rats from the same group in a separate cage. After a week, every female rat was kept in the separate cages. Females received celery extract during pregnancy and until childbirth. Finally, the number of the delivery females, number, weight and sex ratio of offspring were recorded. The data were analyzed by one-way ANOVA test using SPSS15 software. Results: The number of the delivery rats in the experimental groups was not significantly different than the control group (P>0.05). The number of newborns was significantly increased in each experimental group compared to the control group (P0.05). Conclusions: Celery improved fertility due to have flavonoid and antioxidant activity, and its consumption in both sexes can be useful in the treatment of infertility. © 2014 AENSI Publisher All rights reserved

The effect of hydro-alcoholic extract of celery on male rats in fertility control and sex ratio of rat offspring

BACKGROUND AND OBJECTIVE: Celery (Apium graveolens), in traditional medicine is known as appetite and libido stimulant, and also there has been referred to its effect on miscarriage and catamenia. This plant with known plant compounds could be an option for fertility control. This study was conducted to evaluate the effect of hydro-alcoholic extract of celery on male rats in fertility control and sex ratio of rat offspring. METHODS: In this experimental study, 20 male rats were divided randomly into 4 groups, 5 in each group. Control group received no treatment; Sham group received 1 ml normal saline and the treatment groups 1 and 2 received hydro-alcoholic extract of celery in doses of 100 and 200 mg/Kg/BW respectively for 5 weeks. After mating each male rat with two female rats, the number of delivered mice and the number of offspring and their sex were recorded and compared 30 days after the birth. FINDINGS: There was no significance difference between the experimental and control group (p>0.05). The result showed a significant decrease in the number of offspring in doses of 100 and 200 mg/kg (4.25±0.25 and 4.50±0.32 respectively) compared to the control group (7.11±0.26), also a significant increase in the sex ratio in dose of 100 mg/kg (2.93±0.30) compared to the control group (0.98±0.11) was observed (p<0.05). CONCLUSION: It seems that consumption of celery in male decreases the number of offspring and increases the male genesis; because it does not affect on childbirth. It may be useful safely in pregnancy controlling. © 2014, Babol University of Medical Sciences. All rights reserved

The effects of hydro-alcoholic extract of celery on lipid profile of rats fed a high fat diet

Background and Objectives: Decrease in serum lipids by dietary or pharmacological intervention prevents progression of atherosclerosis and cardiovascular diseases. The aim of this study was to investigate the effects of hydro-alcoholic extract of celery (Apium graveolens) on lipid profile of rats fed a high fat diet. Materials and Methods: In this experimental study, 24 Wistar rats were randomly allocated into four groups. The control group received saline with high-fat diet and treatment groups did hydroalcoholic extract at doses of 100 and 200 mg/kg/BW with high fat diet by gavage over a 30-day period. Afterwards, the serum levels of lipids (triglyceride, cholesterol, LDL, HDL, and VLDL) were determined. The data were analyzed by one-way ANOVA test using SPSS15 software. Results: Hydro-alcoholic extract of celery significantly decreased cholesterol and LDL in treatment groups compared with control group (P≤0.05); but had no significant effects in serum levels of triglyceride, HDL, and VLDL (P>0.05). Conclusions: Probably celery consumption due to the antioxidant properties leads to appropriate changes in serum lipid profiles and reduces them. Therefore it could be useful in the treatment of hyperlipidemia. © 2014 AENSI Publisher All rights reserved

Effect of apium graveolens leaf extract on serum level of thyroid hormones in male rat

BACKGROUND AND OBJECTIVE: Celery (APium graveolens) is a medicinal Plant with antioxidant benefits and rich of flavonoid. Since flavonoids have great imPact on Physiological functions of body and esPecially thyroid function, the aim of this study was to investigate the effect of hydro-alcoholic extract of celery leaf on serum level of thyroid hormones. METHODS: In this exPerimental study, 40 male rats were divided into 5 grouPs of eight rats each. They were control, sham (received normal saline) and the exPerimental grouPs received 1 ml of hydro-alcoholic extract of celery with doses of 50,100 and 200 mg/kg during 21 days by using gavage method. One day after the last gavage, the blood samPles were collected by bloodletting from the heart. After PreParing serum, the level of T3‘T4 and TSH hormones were measured using ELISA method. FINDINGS: The serum levels of T3 (0.95±0.04 and 0.95±0.06, resPectively) and T4 (5.42±0.85 and 5.87±0.89, resPectively) hormones decreased (p0.0 5). CONCLUSION: The results showed that prescribing these doses of celery extracts caused the decrease of thyroid hormone level so it could be considered as a balance hyperthyroidism. © 2014, Babol University of Medical Sciences. All rights reserved

The effects of celery leave extract on male hormones in rats

Introduction: Celery (Apium graveolens) belongs to the Umbelliferae family, and has a plenty of nutritional and pharmaceutical applications. The presence of phytoestrogenic compounds has been reported in this plant. These compounds may affect the pituitary-gonad axis. The aim of the present study was to evaluate the efficacy of hydro-alcoholic extracts of celery leaves on serum levels of testosterone, LH and FSH in male rats. Methods: In this experimental study, 32 male Wistar rats were divided into four groups, eight rats included in each. The control group did not receive any treatment. The placebo group received distilled water and the case groups received 200 and 300 mg/kg/B.W of hydro-alcoholic celery leaf extract for 20 consecutive days by oral administration. After completion of the treatment, the rats were anesthetized and blood sampling from their heart was carried out. Then, serum levels of testosterone, LH and FSH were measured using immunoassay methods. The obtained data were analyzed by the SPSS using the statistical ANOVA test. Results: The level of LH in the case group receiving 200 mg/kg B.W of celery extract showed a significant decrease compared with the control and placebo groups (P&lt;0.05). The level of FSH and testosterone in case groups did not show any significant difference in comparison with the control group (P&gt;0.05). Conclusion: The result of the present study shows that in the administered dose, celery extract does not have any considerable side effect on the secretion of hormones in male rats.</p

Anti-fertility effect of hydro-alcoholic extract of fennel (Foeniculum vulgare Mill) seed in male Wistar rats

The study aimed to investigate the anti-fertility effect of fennel (Foeniculim vulgare Mill) seed extract in male rats. Material and Methods: Forty Wistar rats were divided into five equal groups. The control group received distilled water and the experimental groups were orally administered 1 ml of hydro-alcoholic extract of fennel seed in four doses of 35, 70, 140, and 280 mg/kg/b.w. daily for 60 days. After the last gavage, the rats were anaesthetised and the caudal part of the right epididymis was used for sperm counting. After fixation of the testes, microscopic sections were prepared and histological changes were evaluated. Results: The number of spermatogonia after doses of 140 and 280 mg/kg and Sertoli cells after a dose of 140 mg/kg decreased significantly as compared with the control group (P < 0.05). The number of primary spermatocytes and sperm count decreased significantly in the experimental groups (70, 140, and 280 mg/kg) when compared to the control group (P < 0.05). Furthermore, thickening of the basement membrane, cell apoptosis, and irregular arrangement of the germinal epithelium were observed in the experimental groups. Conclusion: Hydro-alcoholic fennel seed extract at these doses could reduce reproductivity and has anti-fertility activity in male rat

Effect of ointment with cabbage, pomegranate peel, and common plantain on wound healing in male rat

زمینه و هدف: تحقیقات بالینی و تجربی متعدد اثربخشی گیاهان دارویی بر روند ترمیم زخم را به اثبات رسانده اند و انار، بارهنگ و کلم از جمله گیاهان مفید در طب سنتی هستند که برای التیام زخم مورد استفاده قرار گرفته اند؛ لذا این مطالعه با هدف بررسی اثر بخشی کرم با اختلاط گیاهان کلم برگ، پیه سفید انار و بخش های هوایی بارهنگ بر زخم پوستی در موش صحرایی طراحی و اجرا شد. روش بررسی: در این مطالعه تجربی 24 راس موش صحرایی بصورت تصادفی به 4 گروه 6 تایی شامل کنترل (سرم فیزیولوژیک)، شاهد (تحت درمان با پتادین)، کنترل مثبت (تحت درمان با فنی توئین) و گروه تجربی تحت درمان با کرم با اختلاط پیه انار، بارهنگ و کلم برگ تقسیم شدند. پس از ایجاد زخم در شرایط غیرعفونی و یکسان، حیوانات بصورت روزانه تحت درمان قرار گرفتند و در روزهای 3، 6، 9 و 14 پس از ایجاد زخم، درصد بهبودی زخم محاسبه گردید. یافته ها: درصد بهبودی زخم در گروه دریافت کننده کرم درمانی در روز های 3، 6، 9 و 14 نسبت به گروه کنترل افزایش معنی داری نشان داد (

Anti-fertility effect of hydro-alcoholic extract of fennel (Foeniculum vulgare Mill) seed in male Wistar rats

Introduction: The study aimed to investigate the anti-fertility effect of fennel (Foeniculim vulgare Mill) seed extract in male rats