69 research outputs found
Experimental constraints on the parameter space of the next-to-minimal supersymmetric standard model at LEP 2
We search for the neutral Higgs sector of the next-to-minimal supersymmetric
standard model at LEP 2. At the tree level any experimental constraints on
cannot be set by the Higgs search at LEP 2 with = 175
GeV, whereas at LEP 2 with = 192 GeV can be set by an
experimental constraint. Furthermore the tree level parameter space of the
model can be completely explored by the Higgs search at LEP 2 with =
205 GeV. Radiative corrections both to the neutral Higgs boson masses and to
the relevant couplings for the scalar Higgs productions give large
contributions to the production cross sections of the scalar Higgs bosons at
the tree level. The tree level situation at LEP 2 with = 192 GeV as
well as with = 205 GeV can be drastically changed by these effects.
We expect that a small region of the 1-loop level parameter space of the model
via the scalar Higgs production can be explored by the Higgs search at LEP 2.Comment: 14 pages (3 figures are included
Establishment of a Transgenic Zebrafish Line for Superficial Skin Ablation and Functional Validation of Apoptosis Modulators In Vivo
BACKGROUND: Zebrafish skin is composed of enveloping and basal layers which form a first-line defense system against pathogens. Zebrafish epidermis contains ionocytes and mucous cells that aid secretion of acid/ions or mucous through skin. Previous studies demonstrated that fish skin is extremely sensitive to external stimuli. However, little is known about the molecular mechanisms that modulate skin cell apoptosis in zebrafish. METHODOLOGY/PRINCIPAL FINDINGS: This study aimed to create a platform to conduct conditional skin ablation and determine if it is possible to attenuate apoptotic stimuli by overexpressing potential apoptosis modulating genes in the skin of live animals. A transgenic zebrafish line of Tg(krt4:NTR-hKikGR)(cy17) (killer line), which can conditionally trigger apoptosis in superficial skin cells, was first established. When the killer line was incubated with the prodrug metrodinazole, the superficial skin displayed extensive apoptosis as judged by detection of massive TUNEL- and active caspase 3-positive signals. Great reductions in NTR-hKikGR(+) fluorescent signals accompanied epidermal cell apoptosis. This indicated that NTR-hKikGR(+) signal fluorescence can be utilized to evaluate apoptotic events in vivo. After removal of metrodinazole, the skin integrity progressively recovered and NTR-hKikGR(+) fluorescent signals gradually restored. In contrast, either crossing the killer line with testing lines or transiently injecting the killer line with testing vectors that expressed human constitutive active Akt1, mouse constitutive active Stat3, or HPV16 E6 element displayed apoptosis-resistant phenotypes to cytotoxic metrodinazole as judged by the loss of reduction in NTR-hKikGR(+) fluorescent signaling. CONCLUSION/SIGNIFICANCE: The killer/testing line binary system established in the current study demonstrates a nitroreductase/metrodinazole system that can be utilized to conditionally perform skin ablation in a real-time manner, and provides a valuable tool to visualize and quantify the anti-apoptotic potential of interesting target genes in vivo. The current work identifies a potential use for transgenic zebrafish as a high-throughput platform to validate potential apoptosis modulators in vivo
Neanderthal Use of Fish, Mammals, Birds, Starchy Plants and Wood 125-250,000 Years Ago
Neanderthals are most often portrayed as big game hunters who derived the vast majority of their diet from large terrestrial herbivores while birds, fish and plants are seen as relatively unimportant or beyond the capabilities of Neanderthals. Although evidence for exploitation of other resources (small mammals, birds, fish, shellfish, and plants) has been found at certain Neanderthal sites, these are typically dismissed as unusual exceptions. The general view suggests that Neanderthal diet may broaden with time, but that this only occurs sometime after 50,000 years ago. We present evidence, in the form of lithic residue and use-wear analyses, for an example of a broad-based subsistence for Neanderthals at the site of Payre, Ardèche, France (beginning of MIS 5/end of MIS 6 to beginning of MIS 7/end of MIS 8; approximately 125–250,000 years ago). In addition to large terrestrial herbivores, Neanderthals at Payre also exploited starchy plants, birds, and fish. These results demonstrate a varied subsistence already in place with early Neanderthals and suggest that our ideas of Neanderthal subsistence are biased by our dependence on the zooarchaeological record and a deep-seated intellectual emphasis on big game hunting
Morphological and histochemical characterization of the digestive tract of the puffer fish Sphoeroides testudineus (Linnaeus 1758) (Tetraodontiformes: Tetraodontidae)
Higgs Physics at LEP2
In this report we review the prospects for Higgs physics at LEP2. The
theoretical aspects and the phenomenology of Higgs particles are discussed
within the Standard Model (SM) and the Minimal Supersymmetric Standard Model
(MSSM). The experimental search techniques are described and the discovery
limits for Higgs bosons in the LEP2 energy range are summarized. In addition,
opportunities of detecting Higgs particles in non-minimal extensions of the SM
and the MSSM are investigated.Comment: 112 pages, latex file + figures (some bitmapped), to appear in Vol.
1, Report of the Workshop on Physics at LEP2, G. Altarelli, T. Sjostrand and
F.Zwirner (eds), CERN 96-01. (Full postscript and uuencoded files, including
full resolution figures are available at the www address
http://surya11.cern.ch/surya_info/users/mcarena in finrep.ps, finrep.uu
La régionalisation de la phase judiciaire de l'expropriation pour cause d'utilité publique
Transfert de compétence.Master [120] en droit (horaire décalé), Université catholique de Louvain, 2015La diffusion de ce mémoire n'est pas autorisée par l'institutio
Guide des travaux pratiques d'histologie générale et d'histologie spéciale des animaux domestiques
SYL-8624 = Première partie ;SYL-8623 = Deuxième partiePremière partie :Histologie générale (tissus), séances 1 à 6 -- Deuxième partie :Histologie spéciale (organes), séances 7 à 20VETE2 - VETE013/VETE014info:eu-repo/semantics/published
Lectin histochemistry on glycoconjugates of the epidermis and dermal glands of Xenopus laevis (Daudin, 1802)
We performed an investigation at the light microscopical level of the differential distribution of lectin-binding sites among cells of the epidermis and glandular domains of the African clawed frog Xenopus laevis. Using a panel of biotinylated lectins (Con-A, PSA, LCA, UEA-I, DBA, SBA, SJA, RCA-I, BSL-I, WGA, s-WGA, PHA-E and PHA-L) and an avidin-biotin-peroxidase complex (ABC), we have identified specific binding patterns. The results show that expression of saccharide moieties in Xenopus epidermal keratinocytes is related to the stage of cellular differentiation, different cell layers expressing diffrent sugar residues. Moreover, oliogosaccharides with "identical" biochemically defined sugar compositions can be distinguished. The method allowed further characterization of complex glycoconjugates of dermal glands. In view of these results, the ABC technique and the biotinylated lectins employed in the present study are believed to be a reliable method for the precise localization of saccharide residues of glycoconjugates present in ectothermic vertebrates. © 1990.SCOPUS: ar.jFLWNAinfo:eu-repo/semantics/publishe
Comparative lectin-binding patterns in the epidermis and dermal glands of bufo bufo (L.) and Xenopus Laevis (Daudin)
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
BY-COVID - Educational Toolkit
The aim of the BY-COVID project is to make infectious disease data accessible to scientists in laboratories, but also to anyone likely to use them, such as medical staff in hospitals or civil servants.
Based on the scientific work in the project, an educational toolkit was created, that is understandable and usable for a wide audience. Case studies have been produced to illustrate issues relating to data: how it is used, how it is protected, where it can be found, the FAIR principles and so on. Talking about the use of this data would raise awareness among future generations about the use of their health data and address a topical issue.
These cases are grouped together in an educational package, which is being disseminated in schools so that teachers can have a discussion with their students about the use of data, from an ethical point of view. The cases are framed by different themes that help to focus the lesson, but the toolkit is designed to be a starting point to be tailored to specific needs
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