Relationships between lifestyle of younger adolescents and family psychological and social factors

Family is the most important institution in the development of personality and health of a child. Namely in family the attitude of child to the various appearances of life and to health develops. Therefore from the viewpoint of the development of health of the younger adolescent it is important to evaluate the interaction between family and health of the adolescent as thoroughly as it is possible. The aim of the study is to evaluate the relationship between the lifestyle of younger adolescents and the familial psychological and social factors. The objectives of the study: 1. To analyse the characteristics of lifestyle of family and to establish the interdependence of lifestyle of parents and children. 2. To explore the correlations between the formation of habits of nutrition, physical activeness and addictions of younger adolescents and the social factors of family. 3. To evaluate the significance of style of family education for the development of lifestyle and risk behaviour of children. 4. To analyse the life satisfaction of parents and children and to evaluate its significance for the risk behaviour of younger adolescents. 5. To prepare the practical recommendations for the enablement of parents to participate actively in the development of healthy lifestyle and risk behaviour prevention of adolescents

Effect of endothelin-1 on osteoblastic differentiation is modified by the level of connexin43: comparative study on calvarial osteoblastic cells isolated from Cx43+/−and Cx43+/+ mice

International audienc

ZO-1 is involved in trophoblastic cell differentiation in human placenta

Trophoblastic cell-cell fusion is an essential event required during human placental development. Several membrane proteins have been described to be directly involved in this process, including connexin 43 (Cx43), syncytin 1 (Herv-W env), and syncytin 2 (Herv-FRD env glycoprotein). Recently, zona occludens (ZO) proteins (peripheral membrane proteins associated with tight junctions, adherens junc-tions, and gap junctions) were shown to be involved in mouse placental development. Moreover, zona occludens 1 (ZO-1) was localized mainly at the intercellular boundaries between human tro-phoblastic cells. Therefore the role of ZO-1 in the dynamic process of human trophoblastic cell-cell fusion was investigated using primary trophoblastic cells in culture. In vitro as in situ, ZO-1 was localized mainly at the intercellular boundaries between trophoblastic cells where its expression substantially decreased during differentiation and during fusion. At the same time, Cx43 was localized at the interfac