Normal Vibrations & Donor Characteristics of Thiazoline-2-thione: Complexes with Cu(II), Cd(II), Ni(II) & Hg(II)

925-92

Infrared Spectral Study of Thiazolidine-2-thione & Its Metal Complexes

170-17

A Clustering Based User-Centered (CBUC) Approach for Integrating Social Data into Groups of Interest

Social web sites by means of huge database websites like Facebook, Twitter and, Linked have been becomes a very important task for day to day life. Thousands and millions of social users are extremely linked from each other to these social websites in favor of networking, conversing, distributing, and sharing by means of each other. Social network sites contain consequently develop into a great source of contents of interest, part of which might reduce into the scope of interests of a known group. Therefore no well-organized solution has been proposed in recent works for a grouping of social users depending on their interest’s information, particularly when they are confined by and speckled across diverse social network sites. Clustering Based User-Centered (CBUC) approach is proposed for integrating social data into groups of interests. Proposed CBUC approach follows the procedure of Modified Fuzzy C Means (MFCM) clustering for social grouping of social data user into different group based on their searching interest. This CBUC approach allows users grouping of user social data from various social network sites such as Facebook, Twitter, and LinkedIn by means of their respective groups of interest. CBUC approach the users are clustered by converting of individual social data interest into fuzzification value and verified using the fuzzy objective function. Additional, to reduce the number of iterations, the proposed CBUC approach, MFCM initializes the centroid by means of dist-max initialization algorithm earlier than the execution of MFCM algorithm iteratively. In this approach the users are also capable to personalize their sharing settings and interests contained by their individual groups related to their own preferences. CBUC approach makes it potential in the direction of aggregate social information of the group’s members and extracts from these data the information appropriate to the group's subject of interests. Furthermore, it follows a CBUC design permitting each member in the direction of personalize his/her sharing situation and interests surrounded by their individual groups

Diversity analysis of moringa (Moringa oleifera Lam.) mutant populations revealing extensive genetic variability for the morphological traits

Moringa is renowned as the miracle tree for its versatile applications in food, medicine, plant growth stimulation, animal feed, and its nutritional, pharmacological, and biotechnological potential. Initially, the mutation was induced by treating the seeds with gamma rays (100 Gy, 200Gy and 300 Gy) and Ethyl methane sulphonate (EMS) at 0.15%, 0.20% and 0.25%. Based on continuous evaluation of mutants from M1 to M3 generation, four selected mutant families: 15-1-09, 35-1-62, 35-1-63 and 35-1-68, with 15 mutants from each family were studied to identify high-performing mutants alongside PKM 1 Moringa. Principal component analysis (PCA) of 12 morphological traits for each mutant family revealed five principal components with eigenvalues exceeding one, collectively explaining 78.19, 74.88, 79.85 and 83.80% of the total variability from the mutant families 15-1-09, 35-1-63, 35-1-62, and 35-1-68 respectively. The analysis highlighted that foliage density, apex shape of the first leaf blade, leaf shape, and plant growth habit exhibited the highest variation, while the remaining traits showed lower variability. Through Agglomerative Hierarchical Clustering (AHC) and Principal Component Analysis (PCA), the genotypes 15-1-09-39, 35-1-62-72, 35-1-62-73, 35-1-68-79, and 35-1-63-06 emerged as the most diverse genotypes based on seedling hypocotyls colour, young shoot colour and petiole: anthocyanin colouration of the axis and branches. Hence, through this study, the identified diverse genotypes for specific traits of interest can be included in the moringa breeding programs for crop improvement.

Synthesis of Functionalized 1,4-Azaborinines by the Cyclization of Di-tert-butyliminoborane and Alkynes

Di-tert-butyliminoborane is found to be a very useful synthon for the synthesis of a variety of functionalized 1,4-azaborinines by the Rh-mediated cyclization of iminoboranes with alkynes. The reactions proceed via [2 + 2] cycloaddition of iminoboranes and alkynes in the presence of [RhCl(PiPr3)2]2, which gives a rhodium η4-1,2-azaborete complex that yields 1,4-azaborinines upon reaction with acetylene. This reaction is compatible with substrates containing more than one alkynyl unit, cleanly affording compounds containing multiple 1,4-azaborinines. The substitution of terminal alkynes for acetylene also led to 1,4-azaborinines, enabling ring substitution at a predetermined location. We report the first general synthesis of this new methodology, which provides highly regioselective access to valuable 1,4-azaborinines in moderate yields. A mechanistic rationale for this reaction is supported by DFT calculations, which show the observed regioselectivity to arise from steric effects in the B-C bond coupling en route to the rhodium η4-1,2-azaborete complex and the selective oxidative cleavage of the B-N bond of the 1,2-azaborete ligand in its subsequent reaction with acetylene.</p

Effect of rifampicin & isoniazid on the steady state pharmacokinetics of moxifloxacin.

BACKGROUND & OBJECTIVES Moxifloxacin (MFX) is reported to have promising antimycobacterial activity, and has a potential to shorten tuberculosis (TB) treatment. We undertook this study to examine the influence of rifampicin (RMP) and isoniazid (INH) on the steady state pharmacokinetics of MFX individually in healthy individuals. METHODS A baseline pharmacokinetic study of MFX (400 mg once daily) was conducted in 36 healthy adults and repeated after one week of daily MFX with either RMP (450/600 mg) (n = 18) or INH (300 mg) (n = 18). Plasma MFX concentrations were determined by a validated HPLC method. RESULTS Plasma peak concentration and exposure of MFX was significantly lower and plasma clearance significantly higher when combined with RMP (P<0.001). The C max to MIC and AUC 0-12 to MIC ratios of MFX were significantly lower during concomitant RMP (P<0.001). INH had no significant effect on the pharmacokinetics of MFX. INTERPRETATION & CONCLUSIONS Concomitant RMP administration caused a significant decrease in C max and AUC 0-12 of MFX, the mean decreases being 26 and 29 per cent, respectively. It is uncertain whether this decrease would affect the treatment efficacy of MFX. Prospective studies in TB patients are needed to correlate MFX pharmacokinetics with treatment outcomes

Monothiodiacetamide Complexes with Ni(II), Zn(II), Cd(II) & Hg(II) Chlorides

165-16

Infrared Spectra & Normal Coordinate Analysis of Bis(thioacethydrazidato)nickel(II)

134-13