The Characteristic of the Immune Status at Hiv-Infected Children with Acute Rhinosinusitis

The immune status has been studied at 25 HIV-infected of children with ARS. The control group of comparison consisted from 14 practically healthy faces. At a HIV-infected of patients with ARS has revealed deep infringements of the immune status, especially from the T-link of immunity and its subpopulations, and also frustration humoral an immunity link, suppression of proinflammatory cy-tokine IL-10 and increase proinflammatory IFN-γ. Under the influence of the spent treatment have not revealed certain changes from the immune status at patients. It is possible to ascertain only positive changes of maintenance IL-10 and parallel decrease IFN-γ in dynamics of treatment

Haploidentical Hematopoietic Stem-Cell Transplantation in Adults

Haploidentical hematopoietic stem-cell transplantation is an alternative transplant strategy for patients without an HLA-matched donor. Still, only half of patients who might benefit from transplantation are able to find an HLA-matched related or unrelated donor. Haploidentical donor is readily available for many patients in need of immediate stem-cell transplantation. Historical experience with haploidentical stem-cell transplantation has been characterised by a high rejection rate, graft-versus-host disease, and transplant-related mortality. Important advances have been made in this field during the last 20 years. Many drawbacks of haploidentical transplants such as graft failure and significant GVHD have been overcome due to the development of new extensive T cell depletion methods with mega dose stem-cell administration. However, prolonged immune deficiency and an increased relapse rate remain unresolved problems of T cell depletion. New approaches such as partial ex vivo or in vivo alloreactive T cell depletion and posttransplant cell therapy will allow to improve immune reconstitution in haploidentical transplants. Results of unmanipulated stem-cell transplantation with using ATG and combined immunosuppression in mismatched/haploidentical transplant setting are promising. This paper focuses on recent advances in haploidentical hematopoietic stem-cell transplantation for hematologic malignancies

The Expression of width and Colour Plane in the Sur Karakul Lambs of Different Colours

The results of research into similar and distinctive features in the study of curl breadth and color consistency of karakul lambs of harsh diamond and silver coloration are presented in this article

Hematopoietic Stem Cell Transplantation in Thalassemia and Sickle Cell Disease. Unicenter Experience in a Multi-Ethnic Population.

Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia. Results of transplant in thalassemia and in sickle cell anemia have steadily improved over the last two decades due to improvements in preventive strategies, and effective control of transplant-related complications. From 2004 through 2009, 145 consecutive patients with thalassemia and sickle cell anemia, ethnically heterogeneous from Mediterranean and Middle East countries, were given HSCT in the International Center for Transplantation in Thalassemia and Sickle Cella Anemia in Rome. This experience is characterized by two peculiarities: patients were ethnically very heterogeneous and the vast majority of these patients were not regularly transfesed/chelated and therefore were highly sensitized due to RBC transfusions without leukodepletion filters. Consequently, they could have a high risk of graft rejection as a result of sensitization to HLA antigens. The Rome experience of SCT in patients with thalassemia and sickle cell anemia confirmed the results obtained in Pesaro, and most importantly showed the reproducibility of these results in other centers

Percutaneous tibial nerve stimulation (PTNS) efficacy in the treatment of lower urinary tract dysfunctions. A systematic review

Background: Percutaneous Tibial Nerve Stimulation (PTNS) has been proposed for the treatment of overactive bladder syndrome (OAB), non-obstructive urinary retention (NOUR), neurogenic bladder, paediatric voiding dysfunction and chronic pelvic pain/painful bladder syndrome (CPP/PBS). Despite a number of publications produced in the last ten years, the role of PTNS in urinary tract dysfunctions remains unclear. A systematic review of the papers on PTNS has been performed with the aim to better clarify potentialities and limits of this technique in the treatment of OAB syndrome and in other above mentioned urological conditions. Methods. A literature search using MEDLINE and ISI web was performed. Search terms used were "tibial nerve" and each of the already mentioned conditions, with no time limits. An evaluation of level of evidence for each paper was performed. Results: PTNS was found to be effective in 37-100% of patients with OAB, in 41-100% of patients with NOUR and in up to 100% of patients with CPP/PBS, children with OAB/dysfunctional voiding and patients with neurogenic pathologies. No major complications have been reported.Randomized controlled trials are available only for OAB (4 studies) and CPP/PBS (2 studies). Level 1 evidence of PTNS efficacy for OAB is available. Promising results, to be confirmed by randomized controlled studies, have been obtained in the remaining indications considered. Conclusions: PTNS is an effective and safe option to treat OAB patients. Further studies are needed to assess the role of PTNS in the remaining indications and to evaluate the long term durability of the treatment. Further research is needed to address several unanswered questions about PTNS

High-current contactless ferromagnetic converters for multi-profile monitoring and control systems

The article shows that the undesirability of breaking the current circuit for the temporary inclusion of electrical measuring devices, the presence of large power losses on shunts, the impossibility of breaking the circuit under the conditions of the technological process, as well as safety requirements caused contactless conversion and measurement of large DC currents in circuits without breaking them in metallurgy, electrochemical industry, railway transport, in laser technology, renewable energy sources, land reclamation, irrigation and in general in agriculture. Lightweight detachable wide-band stationary and portable non-destructive contactless converters and meters of large direct currents are not yet mass-produced worldwide. Therefore, it is very important to develop and study contactless converters and meters of large direct currents, having an extended range of converted currents with small dimensions and weight and increased accuracy and sensitivity, a simplified and technologically advanced design with low material consumption and cost, and the ability to convert both constant and variable high currents and fixed sensitivity control. All these requirements are met by the effective multifunctional magneto-modulating contactless converters of large direct currents developed by us. The results of the development of one of them are given in the work. The issues of its dynamics are considered. The results of his research are shown. It was found that the transition time for him is 0.025 of the period of the industrial frequency. Therefore, it can be considered practically inertia-free. The developed effective multifunctional magneto-modulating contactless converter can be widely used in monitoring and control systems in water supply, land reclamation, and irrigation, industry, railway transport, metallurgy, science, technology for contactless monitoring of constant and alternating currents, as well as for checking electric meters at the place of their installation

Contactless wide-range ferromagnetic high-current converters for monitoring and control systems in the electric power industry

The paper shows that the impossibility of breaking the current circuit for the production necessity of temporarily switching on electrical measuring instruments, large power losses on shunts, and the need to obtain quick information about the quality of the functioning of technological processes have led to the widespread use of non-contact conversion and measurement of high direct currents in circuits without breaking them. Light detachable wide-range stationary and portable non-contact transducers and meters of high direct currents are not yet mass-produced. In this regard, it is expedient to develop and study non-contact converters and meters of high direct currents, which are distinguished by a wide range of converted currents, small dimensions and weight, increased accuracy, and sensitivity of electric power facilities. The questions of sensitivity of magneto-modulation non-contact transducers are considered. The expression for the optimal static characteristic of the developed magneto-modulation non-contact transducer is determined and analyzed. Its maximum deviation from the calculated value does not exceed 6%. The expressions for the current, average sensitivity, and sensitivity regarding the magnitude of the excitation of a magneto-modulation non-contact transducer are obtained and investigated. In this case, the maximum sensitivity of the transducer reaches a value of 0.425 with an optimal excitation value of 1.65. It is recommended to take the allowable limit of the input value of the converter to be less than one. Its input value must be taken equal to 0.7. The developed magneto-modulation non-contact transducer has an increased sensitivity due to longitudinal modulation. It can be widely applied in control and management systems in melioration and irrigation, water supply, industry, metallurgy, railway transport, science, technology, GIS technology, and, in particular, digital coverage and database visualization, and as well as for checking electric meters at the place of their installation for non-contact control of direct, as well as alternating currents

Backfill mixtures based on industrial waste

The object of the study is filling mixtures based on waste from the mining, energy, and copper-smelting industries, Portland cement, and superplasticizer. In the course of the study, standardized methods for studying the properties and quality indicators of industrial waste and filling mixtures based on it and mathematical methods for optimizing the compositions of mixtures, statistical methods for analyzing the results of experiments, were used. It has been established that, in terms of their physical and mechanical characteristics, stowing mixtures based on waste are not inferior to mixtures based on natural materials. The mathematical method for planning experiments has revealed the dependences linking strength with the quantitative characteristics of the components of the filling mixture. Based on the established regularities, an optimization model has been developed that minimizes the consumption of the binder and establishes a relationship between the composition and properties of the mixture