Heuristic Spike Sorting Tuner (HSST), a framework to determine optimal parameter selection for a generic spike sorting algorithm

Extracellular microelectrodes frequently record neural activity from more than one neuron in the vicinity of the electrode. The process of labeling each recorded spike waveform with the identity of its source neuron is called spike sorting and is often approached from an abstracted statistical perspective. However, these approaches do not consider neurophysiological realities and may ignore important features that could improve the accuracy of these methods. Further, standard algorithms typically require selection of at least one free parameter, which can have significant effects on the quality of the output. We describe a Heuristic Spike Sorting Tuner (HSST) that determines the optimal choice of the free parameters for a given spike sorting algorithm based on the neurophysiological qualification of unit isolation and signal discrimination. A set of heuristic metrics are used to score the output of a spike sorting algorithm over a range of free parameters resulting in optimal sorting quality. We demonstrate that these metrics can be used to tune parameters in several spike sorting algorithms. The HSST algorithm shows robustness to variations in signal to noise ratio, number and relative size of units per channel. Moreover, the HSST algorithm is computationally efficient, operates unsupervised, and is parallelizable for batch processing

Nottinghamshire and the Great Peace: reflections on the end of the Napoleonic Wars, 1814-1815

This article explores Nottingham’s ambivalent attitude to the battle of Waterloo, which concluded hostilities between England and France in June 1815. It poses a contrast between Nottingham’s muted reaction to Waterloo and the town’s exuberant commemoration of the general peace between England and France the year before. The article considers different reasons for this, including Nottingham’s response to earlier set-piece battles on the continent and its reaction to domestic political events. The article explores Nottingham’s commitment to radical politics before 1815, as symbolised in its continued petitioning of parliament, and its patriotic commitment to the defeat of Napoleon Bonaparte. The article argues that it was the disappointment of the town’s hopes for economic relief, following the end of hostilities in 1814, combined with fears of a further prolonged period of conflict and delays to parliamentary reform, which helps to explain the town’s attitude during Napoleon’s ‘Hundred Days’ (March-June 1815) and after Waterloo

Microscopic analysis of multipole susceptibility of actinide dioxides: A scenario of multipole ordering in AmO2_2

By evaluating multipole susceptibility of a seven-orbital impurity Anderson model with the use of a numerical renormalization group method, we discuss possible multipole states of actinide dioxides at low temperatures. In particular, here we point out a possible scenario for multipole ordering in americium dioxide. For Am$^{4+}$ ion with five $5f$ electrons, it is considered that the ground state is $\Gamma_7^{-}$ doublet and the first excited state is $\Gamma_8^{-}$ quartet, but we remark that the $f^5$ ground state is easily converted due to the competition between spin-orbit coupling and Coulomb interactions. Then, we find that the $\Gamma_8^-$ quartet can be the ground state of AmO$_2$ even for the same crystalline electric field potential. In the case of $\Gamma_8^-$ quartet ground state, the numerical results suggest that high-order multipoles such as quadrupole and octupole can be relevant to AmO$_2$.Comment: 8 pages, 4 figures. To appear in Phys. Rev.

Local availability and long-range trade: the worked stone assemblage

Inter disciplinary study of major excavation assemblage from Norse settlement site in Orkney. Combines methodological and typological developments with scientific discussion

Effect of temperature on the permeability of lava dome rocks from the 2004–2008 eruption of Mount St. Helens

As magma ascends to shallow levels in the volcanic conduit, volatile exsolution can produce a dramatic increase in the crystal content of the magma. During extrusion, low porosity, highly crystalline magmas are subjected to thermal stresses which generate permeable microfracture networks. How these networks evolve and respond to changing temperature has significant implications for gas escape and hence volcano explosivity. Here, we report the first laboratory experimental study on the effect of temperature on the permeability of lava dome rocks under environmental conditions designed to simulate the shallow volcanic conduit and lava dome. Samples were collected for this study from the 2004–2008 lava dome eruption of Mount St. Helens (Washington State, USA). We show that the evolution of microfracture networks, and their permeability, depends strongly on temperature changes. Our results show that permeability decreases by nearly four orders of magnitude as temperature increases from room temperature to 800 °C. Above 800 °C, the rock samples become effectively impermeable. Repeated cycles of heating leads to sample compaction and a reduction in fracture density and therefore a decrease in permeability. We argue that changes in eruption regimes from effusive to explosive activity can be explained by strongly decreasing permeability caused by repeated heating of magma, conduit walls and volcanic plugs or domes. Conversely, magma becomes more permeable as it cools, which will reduce explosivity

Parents' involvement in child care: do parental and work identities matter?

The current study draws on identity theory to explore mothers' and fathers' involvement in childcare. It examined the relationships between the salience and centrality of individuals’ parental and work-related identities and the extent to which they are involved in various forms of childcare. A sample of 148 couples with at least one child aged 6 years or younger completed extensive questionnaires. As hypothesized, the salience and centrality of parental identities were positively related to mothers' and fathers' involvement in childcare. Moreover, maternal identity salience was negatively related to fathers' hours of childcare and share of childcare tasks. Finally, work hours mediated the negative relationships between the centrality of work identities and time invested in childcare, and gender moderated this mediation effect. That is, the more central a mother's work identity, the more hours she worked for pay and the fewer hours she invested in childcare. These findings shed light on the role of parental identities in guiding behavioral choices, and attest to the importance of distinguishing between identity salience and centrality as two components of self-structure

Finite-Size Scaling at Phase Coexistence

{}From a finite-size scaling (FSS) theory of cumulants of the order parameter at phase coexistence points, we reconstruct the scaling of the moments. Assuming that the cumulants allow a reconstruction of the free energy density no better than as an asymptotic expansion, we find that FSS for moments of low order is still complete. We suggest ways of using this theory for the analysis of numerical simulations. We test these methods numerically through the scaling of cumulants and moments of the magnetization in the low-temperature phase of the two-dimensional Ising model. (LaTeX file; ps figures included as shar file)Comment: preprint HLRZ 27/93 and LU TP 93-

Universal Formulae for Percolation Thresholds

A power law is postulated for both site and bond percolation thresholds. The formula writes $p_c=p_0[(d-1)(q-1)]^{-a}d^{\ b}$, where $d$ is the space dimension and $q$ the coordination number. All thresholds up to $d\rightarrow \infty$ are found to belong to only three universality classes. For first two classes $b=0$ for site dilution while $b=a$ for bond dilution. The last one associated to high dimensions is characterized by $b=2a-1$ for both sites and bonds. Classes are defined by a set of value for $\{p_0; \ a\}$. Deviations from available numerical estimates at $d \leq 7$ are within $\pm 0.008$ and $\pm 0.0004$ for high dimensional hypercubic expansions at $d \geq 8$. The formula is found to be also valid for Ising critical temperatures.Comment: 11 pages, latex, 3 figures not include