105 research outputs found

    Sigh in supine and prone position during acute respiratory distress syndrome

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    Interventions aimed at recruiting the lung of patients with acute respiratory distress syndrome (ARDS) are not uniformly effective. Because the prone position increases homogeneity of inflation of the lung, we reasoned that it might enhance its potential for recruitment. We ventilated 10 patients with early ARDS (PaO2/FIO2, 121 +/- 46 mm Hg; positive end-expiratory pressure, 14 +/- 3 cm H2O) in supine and prone, with and without the addition of three consecutive "sighs" per minute to recruit the lung. Inspired oxygen fraction, positive end-expiratory pressure, and minute ventilation were kept constant. Sighs increased PaO2 in both supine and prone (p < 0.01). The highest values of PaO2 (192 +/- 41 mm Hg) and end-expiratory lung volume (1840 +/- 790 ml) occurred with the addition of sighs in prone and remained significantly elevated 1 hour after discontinuation of the sighs. The increase in PaO2 associated with the sighs, both in supine and prone, correlated linearly with the respective increase of end-expiratory lung volume (r = 0.82, p < 0.001). We conclude that adding a recruitment maneuver such as cyclical sighs during ventilation in the prone position may provide optimal lung recruitment in the early stage of ARDS

    Vertical Specialization, Tariff Shirking and Trade

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    The core idea behind the paper is that trade policy matters for the organization of global value chains, a notion largely neglected by economists but which has important implications for our understanding of trade and the international transmission of trade policy shocks. We develop a theoretical model in which a firm's ability to spatially separate manufacturing from headquarter services gives them the flexibility to circumvent economy-specific tariff changes by switching their assembly location abroad. We show that tariff shirking increases the elasticity of bilateral trade to economy-specific tariff hikes due to an extra extensive margin effect. Furthermore, we show that tariff shirking affects the vulnerability of headquarter services and manufacturing to trade policy shocks in opposite ways. While tariff shirking dampens the vulnerability of headquarter services to trade policy shocks, it amplifies the vulnerability of manufacturing to trade policy shocks. Using firm-level and province-level export data from the People's Republic of China, we provide evidence in line with the theoretical model

    Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

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    Unsupervised and Supervised Learning in cascade for Petroleum Geology

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    Cascade of unsupervised and supervised learning algorithms are suitable in all those problems where there are large unlabelled input datasets and the underlying data structure is hidden and not clearly defined. In petroleum geology the understanding and characterization of reservoirs needs integration of different subsurface data in order to create reliable reservoir models. The large amount of data for each well and the presence of different wells to be simultaneously analysed make this task both complex and time consuming. In this scenario, the development of reliable characterization methods is of prime importance in order to help the geologist and reduce the subjectivity of data interpretation. In this paper, we propose a novel interpretation system based on the use of unsupervised and supervised learning techniques in cascade. Using unsupervised algorithm the domain expert identifies relevant clusters that will be used as classes in the following step, in order to learn a classifier to be applied to new instances and wells. We test the approach over five real well dataset using different evaluating techniques. Main advantages of this approach are the ability to manage and use a large amount of data simultaneously and the reduction in interpretation time of a group of wells

    Vaccino: sviluppo, efficacia, effectiveness e sicurezza

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    I primi vaccini per la pertosse furono sviluppati negli anni ‘30 ed utilizzati nella maggior parte delle nazioni industrializzate a partire dagli anni ‘40 e ‘50. Questi primi vaccini erano a cellule intere (wP), costituiti dall’agente eziologico ucciso in combinazione con il tossoide difterico e tetanico e somministrati in tre dosi entro i 6 mesi di vita. Questo vaccino, nonostante la sua effi cacia, era considerato molto reattogeno ed alcuni studi lo correlarono alla comparsa di sintomi neurologici (ipotonia-iporesponsività) e danni neurologici permanenti

    Femmes en migration en Afrique de l’Ouest : un avenir d’émancipation ?

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    This article deals with female cross - border migration in West Africa. It is based on a research project on women migration (2020 - 2021), coordinated by the Réseau d’Étude des Migrations internationales africaines (REMIGRAF), of the Cheikh Anta Diop University in Dakar. It highlights some results of the research, such as the specificity of the needs, the choices and strategies of women migrants, the adaptive and vulnerability factors, useful to local and regional (i.e. ECOWAS) sustainable public policies
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