Estrategia para prevención del accidente de trabajo por exposición a riesgo biológico al cuerpo de custodia para reclusión de mujeres.

Diseñar una estrategia para la prevención de accidentes de trabajo por exposición a riesgo biológico al cuerpo de custodia para reclusión de mujeres mediante la aplicación de intervenciones en el primer periodo del 2019.A la necesidad que se encontró en el cuerpo de custodia para reclusión de mujeres en el manejo posterior a un evento generado por accidente de trabajo dentro de todos los riesgos a los que están expuestos y como mayor predominancia validada por su matriz de riesgos se encontró en primera estancia riesgo biológico; donde no hay una directriz guiada de cómo actuar durante la atención y posterior seguimiento individual de manejo para la inmunización, y exámenes de control; se dio inicio a tomar información por medio de encuestas y lo referido por cada uno de los colaboradores que hicieron parte de esta intervención para poder llegar a dejar el entregable que podrán manejar y/o consultar de manera oportuna logrando así mitigar las enfermedades y efectos secundarios. La metodología de enfoque es mixto teniendo en cuenta que hay resultados que se debieron tomar de manera subjetiva ante la falta de información cuantitativa; existe el reglamento de higiene pero no se encontró publicado ni la evidencia en físico firmada desu socialización. Dentro de otras informaciones a las que no se tuvo acceso fue a la estadística de accidentalidad reportada y su plan de acción. Durante las diferentes actividades realizadas como la encuesta, capacitación y testimonios, se ve un desconocimiento parcial de que pueden hacer ellos como individuos para su seguimiento personal; a la fecha de las personas intervenidas ninguna refirió haber tendido exámenes de control y vacunación luego de un accidente de trabajo por riesgo biológico. La capacitación fue una herramienta fundamental para lograran entender y resolver dudas de lo que puede llegar a generar una enfermedad por este tipo de evento.To the need found in the custody corps for women's confinement in the management after an event generated by an accident at work within all the risks to which they are exposed and as the most predominant validated by their risk matrix, biological risk was found in the first stay; where there is no guided guideline on how to act during the care and subsequent individual follow-up of management for immunization and control tests; we began to take information through surveys and what was referred by each of the collaborators who were part of this intervention in order to be able to leave the deliverable that they can handle and/or consult in a timely manner, thus mitigating diseases and side effects. The methodology of approach is mixed, taking into account that there are results that should be taken subjectively due to the lack of quantitative information; there is a hygiene regulation but it was not published or signed physical evidence of its socialization. Other information to which we did not have access was the accident statistics reported and its action plan. During the different activities carried out, such as the survey, training and testimonies, there is a partial lack of knowledge of what they can do as individuals for their personal follow-up; to date, none of the people interviewed reported having undergone control and vaccination examinations after a work accident due to biological risk. The training was a fundamental tool for them to understand and resolve doubts about what can generate an illness due to this type of even

Estrategia para prevención del accidente de trabajo por exposición a riesgo biológico al cuerpo de custodia para reclusión de mujeres.

Diseñar una estrategia para la prevención de accidentes de trabajo por exposición a riesgo biológico al cuerpo de custodia para reclusión de mujeres mediante la aplicación de intervenciones en el primer periodo del 2019.A la necesidad que se encontró en el cuerpo de custodia para reclusión de mujeres en el manejo posterior a un evento generado por accidente de trabajo dentro de todos los riesgos a los que están expuestos y como mayor predominancia validada por su matriz de riesgos se encontró en primera estancia riesgo biológico; donde no hay una directriz guiada de cómo actuar durante la atención y posterior seguimiento individual de manejo para la inmunización, y exámenes de control; se dio inicio a tomar información por medio de encuestas y lo referido por cada uno de los colaboradores que hicieron parte de esta intervención para poder llegar a dejar el entregable que podrán manejar y/o consultar de manera oportuna logrando así mitigar las enfermedades y efectos secundarios. La metodología de enfoque es mixto teniendo en cuenta que hay resultados que se debieron tomar de manera subjetiva ante la falta de información cuantitativa; existe el reglamento de higiene pero no se encontró publicado ni la evidencia en físico firmada desu socialización. Dentro de otras informaciones a las que no se tuvo acceso fue a la estadística de accidentalidad reportada y su plan de acción. Durante las diferentes actividades realizadas como la encuesta, capacitación y testimonios, se ve un desconocimiento parcial de que pueden hacer ellos como individuos para su seguimiento personal; a la fecha de las personas intervenidas ninguna refirió haber tendido exámenes de control y vacunación luego de un accidente de trabajo por riesgo biológico. La capacitación fue una herramienta fundamental para lograran entender y resolver dudas de lo que puede llegar a generar una enfermedad por este tipo de evento.To the need found in the custody corps for women's confinement in the management after an event generated by an accident at work within all the risks to which they are exposed and as the most predominant validated by their risk matrix, biological risk was found in the first stay; where there is no guided guideline on how to act during the care and subsequent individual follow-up of management for immunization and control tests; we began to take information through surveys and what was referred by each of the collaborators who were part of this intervention in order to be able to leave the deliverable that they can handle and/or consult in a timely manner, thus mitigating diseases and side effects. The methodology of approach is mixed, taking into account that there are results that should be taken subjectively due to the lack of quantitative information; there is a hygiene regulation but it was not published or signed physical evidence of its socialization. Other information to which we did not have access was the accident statistics reported and its action plan. During the different activities carried out, such as the survey, training and testimonies, there is a partial lack of knowledge of what they can do as individuals for their personal follow-up; to date, none of the people interviewed reported having undergone control and vaccination examinations after a work accident due to biological risk. The training was a fundamental tool for them to understand and resolve doubts about what can generate an illness due to this type of even

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele