34 research outputs found
Mitral Stenosis Presenting with Acute Hearing Loss
A 47-year old woman presented with acute hearing loss, followed by dyspnea and then reduced consciousness and a hemiparesis. Investigations led to a diagnosis of cardiac emboli related to rheumatic mitral stenosis
Assessment of insulin resistance by a 13C glucose breath test: a new tool for early diagnosis and follow-up of high-risk patients
<p>Abstract</p> <p>Background/Aims</p> <p>Insulin resistance (IR) plays an important role in the pathogenesis of diabetes and non-alcoholic fatty liver disease (NAFLD). Current methods for insulin resistance detection are cumbersome, or not sensitive enough for early detection and follow-up. The BreathID<sup>® </sup>system can continuously analyse breath samples in real-time at the point-of-care. Here we determined the efficacy of the BreathID<sup>® </sup>using the <sup>13</sup>C-Glucose breath test (GBT) for evaluation of insulin resistance.</p> <p>Methods</p> <p>Twenty healthy volunteers were orally administered 75 mg of <sup>13</sup>C-glucose 1-<sup>13</sup>C. An oral glucose tolerance test (OGTT) was performed immediately; followed by serum glucose and insulin level determinations using GBT. GBT and OGTT were repeated following exercise, which alters insulin resistance levels.</p> <p>Results</p> <p>Within-subject correlations of GBT parameters with serum glucose and serum insulin levels were high. Before and after exercise, between-subjects correlations were high between the relative insulin levels and the % dose recoveries at 90 min (PDR 90), and the cumulative PDRs at 60 min (CPDR 60). Pairwise correlations were identified between pre-exercise Homeostasis Model Assessment (HOMA) IR at 90 min and PDR 90; HOMA B (for beta cell function) 120 and CPDR 30; HOMA IR 60 and peak time post-exercise; and HOMA B 150 with PDR 150.</p> <p>Conclusions</p> <p>The non-invasive real-time BreathID<sup>® </sup>GBT reliably assesses changes in liver glucose metabolism, and the degree of insulin resistance. It may serve as a non-invasive tool for early diagnosis and follow up of patients in high-risk groups.</p
The effect of medical students’ gender, ethnicity and attitude towards poetry-reading on the evaluation of a required, clinically-integrated poetry- based educational intervention
Point-of-care continuous 13C-methacetin breath test improves decision making in acute liver disease: Results of a pilot clinical trial
AIM: To assess the role of the 13C-methacetin breath test (MBT) in patients with acute liver disease
S1860 The 13C Breath Test Identifies Decreased Beta-Oxidation and Improved Glucose Tolerance and Hepatic Impairment in Patients With Non Alcoholic Steatohepatitis After an Exercise and Diet Intervention
S1648 Type II Non Classical NKT Lymphocytes Are Crucial for Alleviation of TNBS Induced Immune Colitis: A Role for the Alteration of Membrane Lipid Rafts On Dendritic Cells
T1241 Promotion of CD4+CD25+FOXP3+ Regulatory Cells by Oral Administration of Locally Acting Delayed Release Low-Dose 6MP Formulation Alleviated Crohn's Disease: Results of Phase I/II Clinical Trial
M1264 The Non-Invasive 13C Octanoate Breath Test Accurately Assesses Hepatic Mitochondrial Beta Oxidation Before and After Bariatric Surgery
Angiography of the Left Posterior Circulation of the Brain
<p>Angiography (sagittal view) demonstrates complete occlusion of the left vertebral artery (black arrow).</p