Eine Modellierungsaufgabe zum Thema: "Munterer Partnertausch beim Marienkäfer"

Wachstums - bzw. Populationsmodelle sind in der Biomathematik weit verbreitet. Ausgehend von einer aktuellen Studie zur Fortpflanzung der zweigepunkteten Marienkäfer-Spezies Adalia Bipunctata werden zwei mathematische Modelle vorgestellt, die Schülerinnen und Schüler der Sekundarstufe II im Rahmen einer sogenannten Modellierungswoche erarbeitet haben. Der Ansatz der Schüler basiert in beiden Fällen im Wesentlichen auf einer zeitdiskreten Rekursion, wobei ein Ansatz sich mit dem direkten Aufschreiben der Rekursion beschäftigt und der andere aus einer Skizze zum möglichen Verlauf der Populationen hergeleitet wird. Im Folgenden wollen wir nun die Aufgabenstellung präzisieren und auf weitere wichtige Aspekte des Modellierungskreislaufes (Kaiser 1996, S. 68) wie z.B. das Beschaffen von Daten und das Herleiten eines Modells näher eingehen

Modulation of visual processing of food by transcutaneous vagus nerve stimulation (tVNS)

Present project is concerned with the possibility to modulate the neural regulation of food intake by non-invasive stimulation of the vagus nerve. This nerve carries viscero-afferent information from the gut and other internal organs and therefore serves an important role in ingestive behavior. The electrical stimulation of the vagus nerve (VNS) is a qualified procedure in the treatment of drug-resistant epilepsy and depression. Since weight loss is a known common side effect of VNS treatment in patients with implanted devices, VNS is evaluated as a treatment of obesity. To investigate potential VNS-related changes in the cognitive processing of food-related items, 21 healthy participants were recorded in a 3-Tesla scanner in two counterbalanced sessions. Participants were presented with 72 food pictures and asked to rate how much they liked that food. Before entering the scanner subjects received a 1-h sham or verum stimulation, which was implemented transcutanously with a Cerbomed NEMOS® device. We found significant activations in core areas of the vagal afferent pathway, including left brainstem, thalamus, temporal pole, amygdala, insula, hippocampus, and supplementary motor area for the interaction between ratings (high vs low) and session (verum vs sham stimulation). Significant activations were also found for the main effect of verum compared to sham stimulation in the left inferior and superior parietal cortex. These results demonstrate an effect of tVNS on food image processing even with a preceding short stimulation period. This is a necessary prerequisite for a therapeutic application of tVNS which has to be evaluated in longer-term studies

Kommunikation über Fernsehen im Internet. Social TV als Anschlusskommunikation

Sutter T. Kommunikation über Fernsehen im Internet. Social TV als Anschlusskommunikation. In: Göttlich U, Heinz L, Herbers MR, eds. Ko-Orientierung in der Medienrezeption. Praktiken der Second-Screen-Nutzung. Medien - Kultur - Kommunikation. Wiesbaden: Springer VS; 2017: 29-46

Altered resting-state functional connectivity in patients with chronic bilateral vestibular failure

AbstractPatients with bilateral vestibular failure (BVF) suffer from gait unsteadiness, oscillopsia and impaired spatial orientation. Brain imaging studies applying caloric irrigation to patients with BVF have shown altered neural activity of cortical visual–vestibular interaction: decreased bilateral neural activity in the posterior insula and parietal operculum and decreased deactivations in the visual cortex. It is unknown how this affects functional connectivity in the resting brain and how changes in connectivity are related to vestibular impairment.We applied a novel data driven approach based on graph theory to investigate altered whole-brain resting-state functional connectivity in BVF patients (n= 22) compared to age- and gender-matched healthy controls (n= 25) using resting-state fMRI. Changes in functional connectivity were related to subjective (vestibular scores) and objective functional parameters of vestibular impairment, specifically, the adaptive changes during active (self-guided) and passive (investigator driven) head impulse test (HIT) which reflects the integrity of the vestibulo-ocular reflex (VOR).BVF patients showed lower bilateral connectivity in the posterior insula and parietal operculum but higher connectivity in the posterior cerebellum compared to controls. Seed-based analysis revealed stronger connectivity from the right posterior insula to the precuneus, anterior insula, anterior cingulate cortex and the middle frontal gyrus. Excitingly, functional connectivity in the supramarginal gyrus (SMG) of the inferior parietal lobe and posterior cerebellum correlated with the increase of VOR gain during active as compared to passive HIT, i.e., the larger the adaptive VOR changes the larger was the increase in regional functional connectivity.Using whole brain resting-state connectivity analysis in BVF patients we show that enduring bilateral deficient or missing vestibular input leads to changes in resting-state connectivity of the brain. These changes in the resting brain are robust and task-independent as they were found in the absence of sensory stimulation and without a region-related a priori hypothesis. Therefore they may indicate a fundamental disease-related change in the resting brain. They may account for the patients' persistent deficits in visuo-spatial attention, spatial orientation and unsteadiness. The relation of increasing connectivity in the inferior parietal lobe, specifically SMG, to improvement of VOR during active head movements reflects cortical plasticity in BVF and may play a clinical role in vestibular rehabilitation

Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance.

BACKGROUND: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone receptor β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly expressing the β form of the receptor (pituitary, liver). This study seeks to identify the effects of mutant TRβ on pituitary size. METHODS: High-resolution 3D T1-weighted magnetic resonance images were acquired in 19 patients with RTHβ in comparison to 19 healthy matched controls. Volumetric measurements of the pituitary gland were performed independently and blinded by four different raters (two neuroradiologists, one neurologist, one neuroscientist). RESULTS: Patients with mutant TRβ (resistance to thyroid hormone β, RTHβ) showed elevated free tri-iodothyronine/thyroxine levels with normal thyroid-stimulating hormone levels, whereas healthy controls showed normal thyroid hormone levels. Imaging revealed smaller pituitary size in RTHβ patients in comparison to healthy controls (F(1,35) = 7.05, P = 0.012, partial η2 = 0.17). CONCLUSION: RTHβ subjects have impaired sensitivity to thyroid hormones, along with decreased size of the pituitary gland