Prediction of Loss of Position during Dynamic Positioning Drilling Operations Using Binary Logistic Regression Modeling

The prediction of loss of position in the offshore industry would allow optimization of dynamic positioning drilling operations, reducing the number and severity of potential accidents. In this paper, the probability of an excursion is determined by developing binary logistic regression models based on a database of 42 incidents which took place between 2011 and 2015. For each case, variables describing the configuration of the dynamic positioning system, weather conditions, and water depth are considered. We demonstrate that loss of position is significantly more likely to occur when there is a higher usage of generators, and the drilling takes place in shallower waters along with adverse weather conditions; this model has very good results when applied to the sample. The same method is then applied for obtaining a binary regression model for incidents not attributable to human error, showing that it is a function of the percentage of generators in use, wind force, and wave height. Applying these results to the risk management of drilling operations may help focus our attention on the factors that most strongly affect loss of position, thereby improving safety during these operations

Surfactant Nebulization Therapy During NIPPV Ventilation in Surfactant-Deficient Newborn Piglets

Background In recent years, nasal intermittent positive pressure ventilation (NIPPV) has been growing in popularity as a form of noninvasive ventilation for respiratory support in the initial treatment of neonates with surfactant (SF) deficiency. The combination of this type of ventilation with noninvasive SF administration (by nebulization) is an attractive treatment option for respiratory distress syndrome (RDS)-associated pathophysiology of the neonatal lungs. In this study, we aimed to test the tolerability and efficacy of SF nebulization during NIPPV for the treatment of neonatal RDS. Methods Spontaneously-breathing newborn piglets (n = 6/group) with bronchoalveolar lavage (BAL)-induced RDS were assigned to receive during NIPPV (180 min): poractant alfa (400 mg/kg) via an investigational customized vibrating-membrane nebulizer (eFlow-Neos) or poractant alfa (200 mg/kg) as a bolus using the Insure method or no surfactant (controls). Measurement and results We assessed pulmonary, hemodynamic and cerebral effects and performed histological analysis of lung and brain tissue. After repeated BAL, newborn piglets developed severe RDS (FiO2: 1, pH  70 mmHg, PaO2< 70 mmHg, Cdyn < 0.5 ml/cmH2O/kg). In both SF-treated groups, we observed rapid improvement in pulmonary status and also similar hemodynamic, cerebral behavior, and lung and brain injury scores. Conclusion Our results in newborn piglets with severe BAL-induced RDS show the administration of nebulized poractant alfa using the eFlow-Neos nebulizer during NIPPV to be well tolerated and efficacious, suggesting that this noninvasive SF administration option should be explored further.Drs. Rey-Santano, Mielgo, and Gomez-Solaetxe's institutions received funding from Chiesi Farmaceutici and Carlos III Health Institute (PI18/00166) (co-funded by ERDF/ESF, "Investing in your future") and GIU19/026 (University of the Basque Country Research Group

Aerosol Delivery by Inhalation Catheter and Trachea Digitalization

Neonatal respiratory distress syndrome (RDS) is related with high mortality and morbidity in preterm infants and the best approach to treat it is an open research field. The use of perfluorocarbons (PFC) together with non-invasive respiratory support techniques, such as nasal continuous positive airway pressure (CPAP), has confirmed its effectiveness to achieve a more homogeneous surfactant distribution. The goal of the current study was to evaluate the main features of the aerosol generated by an intracorporeal inhalation catheter, which consists of one central lumen delivering the liquid and six peripheral lumens delivering compressed air. Firstly, experiments were made through an Aerodynamic Particle Sizer (APS) with sterile water and perfluorocarbon FC75 with a driving pressure of 4 bar to analyze properties linked with lung deposition such as the aerodynamic diameter (Da), mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD). Subsequently, a numerical model was developed with CFD techniques. The experimental validation of the numerical model provides an accurate prediction of the air flow axial velocity.This work has been supported by Consolidated Groups from the Basque Government. Technical and human support provided by IZO-SGI, SGIker is gratefully acknowledged

Aerosol Delivery by Inhalation Catheter and Trachea Digitalization

Neonatal respiratory distress syndrome (RDS) is related with high mortality and morbidity in preterm infants and the best approach to treat it is an open research field. The use of perfluorocarbons (PFC) together with non-invasive respiratory support techniques, such as nasal continuous positive airway pressure (CPAP), has confirmed its effectiveness to achieve a more homogeneous surfactant distribution. The goal of the current study was to evaluate the main features of the aerosol generated by an intracorporeal inhalation catheter, which consists of one central lumen delivering the liquid and six peripheral lumens delivering compressed air. Firstly, experiments were made through an Aerodynamic Particle Sizer (APS) with sterile water and perfluorocarbon FC75 with a driving pressure of 4 bar to analyze properties linked with lung deposition such as the aerodynamic diameter (Da), mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD). Subsequently, a numerical model was developed with CFD techniques. The experimental validation of the numerical model provides an accurate prediction of the air flow axial velocity.This work has been supported by Consolidated Groups from the Basque Government. Technical and human support provided by IZO-SGI, SGIker is gratefully acknowledged

Experimental and Numerical Modeling of Aerosol Delivery for Preterm Infants

Respiratory distress syndrome (RDS) represents one of the major causes of mortality among preterm infants, and the best approach to treat it is an open research issue. The use of perfluorocarbons (PFC) along with non-invasive respiratory support techniques has proven the usefulness of PFC as a complementary substance to achieve a more homogeneous surfactant distribution. The aim of this work was to study the inhaled particles generated by means of an intracorporeal inhalation catheter, evaluating the size and mass distribution of different PFC aerosols. In this article, we discuss different experiments with the PFC perfluorodecalin (PFD) and FC75 with a driving pressure of 4-5 bar, evaluating properties such as the aerodynamic diameter (Da), since its value is directly linked to particle deposition in the lung. Furthermore, we develop a numerical model with computational fluid dynamics (CFD) techniques. The computational results showed an accurate prediction of the airflow axial velocity at different downstream positions when compared with the data gathered from the real experiments. The numerical validation of the cumulative mass distribution for PFD particles also confirmed a closer match with the experimental data measured at the optimal distance of 60 mm from the catheter tip. In the case of FC75, the cumulative mass fraction for particles above 10 mu m was considerable higher with a driving pressure of 5 bar. These numerical models could be a helpful tool to assist parametric studies of new non-invasive devices for the treatment of RDS in preterm infants.Consolidated Groups from the Basque Government supported this work. Technical and human support provided by IZO-SGI, SGIker (UPV/EHU) is gratefully acknowledged

Aerosol Delivery by Inhalation Catheter and Trachea Digitalization

Neonatal respiratory distress syndrome (RDS) is related with high mortality and morbidity in preterm infants and the best approach to treat it is an open research field. The use of perfluorocarbons (PFC) together with non-invasive respiratory support techniques, such as nasal continuous positive airway pressure (CPAP), has confirmed its effectiveness to achieve a more homogeneous surfactant distribution. The goal of the current study was to evaluate the main features of the aerosol generated by an intracorporeal inhalation catheter, which consists of one central lumen delivering the liquid and six peripheral lumens delivering compressed air. Firstly, experiments were made through an Aerodynamic Particle Sizer (APS) with sterile water and perfluorocarbon FC75 with a driving pressure of 4 bar to analyze properties linked with lung deposition such as the aerodynamic diameter (Da), mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD). Subsequently, a numerical model was developed with CFD techniques. The experimental validation of the numerical model provides an accurate prediction of the air flow axial velocity.This work has been supported by Consolidated Groups from the Basque Government. Technical and human support provided by IZO-SGI, SGIker is gratefully acknowledged