Prüfung des iMTA Productivity Costs Questionnaire (iPCQ) für den Einsatz bei Patienten/-innen mit chronischen Krankheiten in der Schweiz

Hintergrund: Interprofessionelle Programme im Gesundheitswesen sind angewiesen auf die valide Messung von Outcomes. Der iMTA Productivity Costs Questionnaire (iPCQ) ist eines der wenigen deutschsprachigen Instrumente, das Produktivität umfassend misst. Diese Studie untersucht die Validität des deutschsprachigen iPCQ mit Fokus auf Testinhalt und Antwortprozesse. Ziel dieser Studie ist, die deutschsprachige Version des iPCQ bei Patienten/-innen mit chronischen Erkrankungen in der Schweiz zu überprüfen und Vorschläge für eine Verbesserung der Validität auszuarbeiten. Methode: Diese Studie ist eine qualitative Validierungsstudie. Wir haben kognitive Interviews mit Menschen mit chronischen Krankheiten und auch mit Fachpersonen durchgeführt und basierend auf der Framework-Methode analysiert. Ergebnisse: Personen, die in der Schweiz leben und an einer chronischen Krankheit leiden, haben teilweise Probleme beim Verständnis einzelner Items und Erläuterungen sowie mit dem Abruf von relevanten Informationen aus dem Gedächtnis. Außerdem hat die Studie konstruktbezogene Probleme bei der Messung der Produktivität von Menschen mit Teil-Arbeitsunfähigkeit aufgedeckt. Schlussfolgerungen: Die Ergebnisse zeigen, dass die deutsche Version des Fragebogens verbessert werden sollte, um Validität und Reliabilität zu gewährleisten

Analysis of the Implementation of Total Productive Maintenance, Total Quality Management, and Just-In-Time in Pharmaceutical Manufacturing

In the pharmaceutical industry, systems for improving operational effectiveness and efficiency are becoming more and more popular. In this paper, developments in the industry's improvements in operational effectiveness and efficiency have been analyzed. A holistic model is presented which builds the basis for the presented study results. The study includes data gathered from pharmaceutical production sites in surveys in 2004 and 2009. The analysis is divided according to the four sub-systems: Total Productive Maintenance, Total Quality Management, Just-in-Time, and the Management System. For each sub-system, key performance indicators and associated elements (practices and instruments) from 2004 to 2009 are investigated. The data indicates that the industry did make continuous steps towards "Excellence in Operations” between 2004 and 2009. Pharmaceutical companies took control over their former low asset utilization and managed to improve the efficiency of their quality systems; however, they are still far away from having any kind of "continuous flow”, smooth production scheduling or make-to-order manufacturing. It can be said that most of the companies are still working on the effectiveness side rather than focusing on the efficiency sid

“Holistic Risk-based Site Surveillance – A Data-based Approach to Site Quality Risk Identification and Assessment in the Pharmaceutical Industry”

Effective quality risk management is fundamental in guaranteeing the development and manufacture of high-quality drugs, reducing drug shortages, and avoiding harm to patients’ health. The ability to accurately assess the actual risk environment, predict potential product quality or supply disruption issues and act to eliminate, prevent, reduce or mitigate them is key to improvements in quality management maturity. This paper illustrates a just-launched research project aimed at developing a comprehensive framework for how to assess and predict risks by leveraging a range of diverse factors

Associations between social integration, participation and productivity loss among persons with chronic pain: a registry based cross sectional study.

PURPOSE To examine associations between factors of social inclusion and participation and productivity loss in employed persons with chronic pain, assessed for an interprofessional pain rehabilitation programme. We hypothesized that factors of social inclusion and participation and work related social factors are significantly associated with productivity when experiencing chronic pain and we expected a moderate effect. METHODS Cross-sectional study using data collected prospectively in an interprofessional patient registry for chronic pain. The primary end point was productivity loss, measured with the iMTA Productivity Costs Questionnaire. We included data from 161 individuals. To be included, persons had to be 18 years old or older, in paid work, and had to have a medical diagnosis of chronic pain syndrome with actual or potential tissue damage. In addition, participants had to have indicators of significant impairments in psychosocial functions. RESULTS Linear regression analysis showed that a highly stressful professional situation, frequent problems regarding the compatibility of the family and job and not being Swiss were associated with a significantly higher total productivity loss. Similar results were found for productivity loss in paid work. However, problems concerning the compatibility of the family and job did not reach the significance level for productivity loss in paid work. CONCLUSION The results of this study underscore the importance of factors of social inclusion and participation for interprofessional rehabilitation programmes to manage chronic pain especially when focussing on productivity loss

Intracellular free sodium and potassium, post-carbachol hyperpolarization, and extracellular potassium-undershoot in rat sympathetic neurones

Double-barrelled ion-sensitive microelectrodes were used to record the free intracellular Na+- and K+-concentrations ([Na+]i, [K+]i) and to determine their relation to changes in membrane potential and extracellular K+ ([K+]e) in rat sympathetic ganglia. The application of 50 μmol/l carbachol resulted in an elevation of [K+]e followed by a post-carbachol [K+]e-undershoot. The membrane depolarization of the sympathetic neurones was associated with an increase in [Na+]i and a decrease in [K+]i. A membrane hyperpolarization and a recovery of [K+]i and [Na+]i to their baseline levels were observed during the [K+]e-undershoot. The time course of the [K+]e-undershoot correlated exactly with the duration of the rise in [Na+]i and decrease of [K+]i. No K+-reuptake occurred in the presence of ouabain. These data confirm, by direct measurements of intracellular ion concentration changes, the contribution of the Na+, K+-pump to the post-carbachol membrane hyperpolarization and [K+]e-undershoot

D3_1.Guideline-for-analysis-on-plant-and-mulches

The aim of this handbook of experimental guidelines is to level out analyses run during the Domino project on practices for sustainable management of organic apple orchard and vineyard in field condition. Analysis refer to the main crop and to the performances of species introduced ad living mulches. A second section reports protocol for soil chemical, physical and biological fertility evaluations. Indication are provided for activities run either in structured experimental stations as well as in farm trials. The standard levels of accuracy allowing to collect reliable information are exposed for both experimental condition

A Holistic View on Production Systems Management

Almost every large corporation nowadays operates some sort of Production System (PS), usually built as a derivative from leading examples like the Toyota Production System. Production Systems (PSs) are introduced to increase operational performance and to eventually instill a culture of continuous improvement across the mostly globally dispersed production networks. The main question is not any longer if PSs are helpful but how to manage them. So far there is neither an answer to this question in practice nor in literature. That is, how to design and develop the content, the process and the organizational support structure of a PS, and thus providing a corporate perspective to managing PSs, is heavily under researched. The methodological approach in this paper is twofold. First, a systematic literature review was conducted to identify appropriate papers dealing with this topic. Second, we draw on interviews with corporate representatives being accountable for the PS at 11 respective companies from the Pharmaceutical industry. The companies have been selected based on their maturity of production system implementation. Interviews were transcribed and coded. We found various activities related to the three dimensions of content, process, and structure of PSs. Thereby, we provide an overview of activities for managing PSs. We add to the literature of PSs from a corporate perspective and derive several future research opportunities, such as if there are multiple ways in combining the identified activities to be successful with a PS. Our limitation is that interviewees are from the pharmaceutical industry only, yet the level of sophistication of PSs in this industry and the twofold approach mitigate the limitation

D4_2-D4_5-D3_2.Yearly report of crops yield and quality data as influenced by soil management 2019

Yearly reports on crops yield and quality as influenced by soil management (2018-2019

D2_2. Status Quo Analysis all Countries

STATUS QUO ANALYSIS OF APPLE ORGANIC FARMING IN THE DIFFERENT COUNTRIE

The role of contextual factors on participation in the life area of work and employment after rehabilitation : a qualitative study on the views of persons with chronic pain

Background: A deeper understanding of how contextual factors affect the ability to participate in the life area of work and employment despite chronic musculoskeletal pain is needed as a basis for interprofessional rehabilitation programs. Objective: To investigate which contextual factors influence rehabilitation program clients’ ability to participate in the life area of work and employment, and how they do this. Methods: Nested case study using a realist evaluation framework of interprofessional interventions. Qualitative content analysis of problem-centered interviews to identify influential context-mechanism-outcome configurations. Results: We identified several important context-mechanism-outcome configurations. In the pre-interventional phase, socioeconomic and environmental factors affected two mechanisms, “exhaustion” and “discrimination”. In the intra-interventional phase, the social skills of health professionals and opportunities for discussion with peers affected the ability of program participants to engage with program content. In the post-intervention phase, volitional competences of the social system affected the sustainable application of program content in everyday life. Conclusion: The identified context-mechanism-outcome configurations shows that the ability to participate in the life area of work is interdependent with the ability to participate in other areas of life. In practice and research, assessment and treatment should be carried out based on this understanding