1,821 research outputs found
Talk it up! — Integrating and prioritizing conversational data in documentation
Syllabus for workshop, CoLang 2016This course will introduce participants to some of the basic methodological and theoretical issues related to recording and analyzing everyday conversations. We will discuss specific contributions of naturalistic interactions to understanding aspects of linguistic structure, social interaction, and culture and explore how interactional data can be better integrated into language documentation projects.2015 NSF/BCS 1500841: CoLang 2016: Institute on Collaborative Language Research – ALASKA
Alaska Native Language Cente
Yankee Publishing Inc. v. News America Publishing Inc., 809 F. Supp. 267, 273 (S.D.N.Y. 1992)
Professional Concerns: Remedial Programs: Some Strategies for Creating a Supportive Learning Environment
Professional Concerns is a regular column devoted to the interchange of ideas among those interested in reading instruction. Send your comments and contributions to the editor. If you have questions about reading that you wish to have answered) the ed£tor will find respondents to answer them. Address correspondence to R. Baird Shuman) Department of English) University of Illinois at Urbana-Champaign) Urbana) Illinois) 61801
Issues in Action Formation : Requests and the Problem with x
In previous interactional studies of formats for utterances doing requests, attention has been given to the initial verb (such as can/could or wonder) and possibly the subject (especially I vs you). The current study examines the main types of grammatical variation found in what we call the " x component," that is the segment after the initial verb and subject. We examine two types of requests: those with can you x and those with wonder x, and we find that variations in the x component in these requests are associated with variations in the unfolding development of the request sequences. We thus suggest that the x component is crucial to the interactional work accomplished by the requesting utterance.Peer reviewe
Nonreplicating, Cyst-Defective Type II Toxoplasma Gondii Vaccine Strains Stimulate Protective Immunity against Acute and Chronic Infection
Live attenuated vaccine strains, such as type I nonreplicating uracil auxotroph mutants, are highly effective in eliciting lifelong immunity to virulent acute infection by Toxoplasma gondii. However, it is currently unknown whether vaccine-elicited immunity can provide protection against acute infection and also prevent chronic infection. To address this problem, we developed nonreverting, nonreplicating, live attenuated uracil auxotroph vaccine strains in the type II Δku80 genetic background by targeting the deletion of the orotidine 5′-monophosphate decarboxylase (OMPDC) and uridine phosphorylase (UP) genes. Deletion of OMPDC induced a severe uracil auxotrophy with loss of replication, loss of virulence in mice, and loss of the ability to develop cysts and chronic infection. Vaccination of mice using type II Δku80 Δompdc mutants stimulated a fully protective CD8+ T cell-dependent immunity that prevented acute infection by type I and type II strains of T. gondii, and this vaccination also severely reduced or prevented cyst formation after type II challenge infection. Nonreverting, nonreplicating, and non-cyst-forming Δompdc mutants provide new tools to examine protective immune responses elicited by vaccination with a live attenuated type II vaccine
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