The individual and history in a system of grace : an introduction to the life and thought of Friedrich Adolph Lampe (1683-1729)

https://place.asburyseminary.edu/ecommonsatsdissertations/1956/thumbnail.jp

The Promise and Potential of Transformative Transit-Oriented Development in Gateway Cities

Gateway Cities can accommodate thousands of new housing units and thousands of new jobs on the vacant and underutilized land surrounding their commuter rail stations. This walkable, mixed-use urban land offers an ideal setting for transit-oriented development (TOD) to take hold.Currently, Gateway City commuter rail stations get minimal ridership from downtown neighborhoods and few developers seek out this land for TOD. But changing economic forces may provide opportunities to funnel future development into transit-connected Gateway Cities, generating more inclusive and economically productive growth, reducing road congestion and greenhouse gas (GHG) emissions, increasing housing supply, conserving open space, and improving quality of life in communities throughout the Commonwealth.With generous support from the Barr Foundation, this groundbreaking MassINC research explores the opportunity for TOD in regional urban centers with varying market contexts and estimates the positive outcomes possible if we realize the development potential for TOD in these cities. The report concludes with a strategy to help Massachusetts capture the promise of Gateway City TOD

Nitrofurantoin-induced radiation recall dermatitis.

Radiation recall dermatitis (RRD) is an inflammatory skin reaction that develops in a previously quiescent radiation field triggered most commonly by chemotherapy, particularly anthracyclines and taxanes. Radiation-recall dermatitis secondary to antibiotic therapy is quite rare. The patient is 61-year-old female with a history of squamous cell carcinoma of the left breast treated with neoadjuvant carboplatin, paclitaxel, and anthracycline chemotherapy followed by surgery and subsequent whole breast radiation 6040 cGy. Eight years after completion of her radiation she developed diffuse redness of the left breast after two doses of nitrofurantoin taken for a urinary tract infection. On examination, vital signs were stable and she had an erythematous and excoriated rash on her left breast that clinically appeared to be cellulitis. Given her clinical history, coupled with the temporal relationship of starting an antibiotic, strong consideration was given for antibiotic-induced RRD. Nitrofurantoin was discontinued, and the rash resolved completely within several days. This case demonstrates an example of RRD which is the development of an acute inflammatory skin reaction of a previously irradiated area most commonly triggered by chemotherapeutic agents. This case highlights antimicrobial therapy as a rare cause of RRD and underscores the importance of considering RRD in a patient presenting with an acute rash over a previously irradiated area while on antimicrobial therapy

What do the recent American Heart Association/American College of Cardiology Foundation Clinical Practice Guidelines tell us about the evolving management of coronary heart disease in older adults?

Biological aging predisposes older adults to increased cardiovascular disease (CHD) and greater disease complexity. Given the high age-related prevalence of CHD and age-related compounding factors, the recently updated American Heart Association/American College of Cardiology Foundation CHD-related guidelines increased their focus on older patients. These guidelines are predominately evidence-based (using data from quality randomized clinical trials) and are organized to delineate medications and procedures that best treat particular cardiovascular diseases. While such rationale and thought work well in young and middle aged adults, they become problematic in patients who are very old. Data pertaining to adults aged ≥ 80 are virtually absent from most randomized clinical trials, and even in the instances when very old patients were included, eligibility criteria typically excluded candidates with co-morbidities and complexities of customary CHD patients. While medications and interventions yielding benefit in clinical trials should theoretically produce the greatest benefits for patients with high intrinsic risk, age-related cardiovascular complexities also increase iatrogenic risks. Navigating between the potential for high benefit and high risk in “evidence-based” cardiovascular management remains a key Geriatric Cardiology challenge. In this review we consider the expanded Geriatric Cardiology content of current guidelines, acknowledging both the progress that has been made, as well as the work that still needs to be accomplished to truly address the patient-centered priorities of older CHD patients

High-pressure droplet combustion studies

This is a joint research program, pursued by investigators at the University of Tokyo, UCSD, and NASA Lewis Research Center. The focus is on high-pressure combustion of miscible binary fuel droplets. It involves construction of an experimental apparatus in Tokyo, mating of the apparatus to a NASA-Lewis 2.2-second drop-tower frame in San Diego, and performing experiments in the 2.2-second tower in Cleveland, with experimental results analyzed jointly by the Tokyo, UCSD, and NASA investigators. The project was initiated in December, 1990 and has now involved three periods of drop-tower testing by Mikami at Lewis. The research accomplished thus far concerns the combustion of individual fiber-supported droplets of mixtures of n-heptane and n-hexadecane, initially about 1 mm diameter, under free-fall microgravity conditions. Ambient pressures ranged up to 3.0 MPa, extending above the critical pressures of both pure fuels, in room-temperature nitrogen-oxygen atmospheres having oxygen mole fractions X of 0.12 and 0.13. The general objective is to study near-critical and super-critical combustion of these droplets and to see whether three-stage burning, observed at normal gravity, persists at high pressures in microgravity. Results of these investigations will be summarized here; a more complete account soon will be published

Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome

BACKGROUND:Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, which may result from alteration of the gastrointestinal microbiota following gastrointestinal infection, or with intestinal dysbiosis or small intestinal bacterial overgrowth. This may be treated with antibiotics, but there is concern that widespread antibiotic use might lead to antibiotic resistance. Some herbal medicines have been shown to be beneficial, but their mechanism(s) of action remain incompletely understood. To try to understand whether antibacterial properties might be involved in the efficacy of these herbal medicines, and to investigate potential new treatments for IBS, we have conducted a preliminary study in vitro to compare the antibacterial activity of the essential oils of culinary and medicinal herbs against the bacterium, Esherichia coli.METHODS:Essential oils were tested for their ability to inhibit E. coli growth in disc diffusion assays and in liquid culture, and to kill E. coli in a zone of clearance assay. Extracts of coriander, lemon balm and spearmint leaves were tested for their antibacterial activity in the disc diffusion assay. Disc diffusion and zone of clearance assays were analysed by two-tailed t tests whereas ANOVA was performed for the turbidometric assays.RESULTS:Most of the oils exhibited antibacterial activity in all three assays, however peppermint, lemon balm and coriander seed oils were most potent, with peppermint and coriander seed oils being more potent than the antibiotic rifaximin in the disc diffusion assay. The compounds present in these oils were identified by gas chromatography mass spectrometry. Finally, extracts were made of spearmint, lemon balm and coriander leaves with various solvents and these were tested for their antibacterial activity against E. coli in the disc diffusion assay. In each case, extracts made with ethanol and methanol exhibited potent antibacterial activity.CONCLUSIONS:Many of the essential oils had antibacterial activity in the three assays, suggesting that they would be good candidates for testing in clinical trials. The observed antibacterial activity of ethanolic extracts of coriander, lemon balm and spearmint leaves suggests a mechanistic explanation for the efficacy of a mixture of coriander, lemon balm and mint extracts against IBS in a published clinical trial

On the cohomology rings of tree braid groups

Let $\Gamma$ be a finite connected graph. The (unlabelled) configuration space $UC^n \Gamma$ of $n$ points on $\Gamma$ is the space of $n$-element subsets of $\Gamma$. The $n$-strand braid group of $\Gamma$, denoted $B_n\Gamma$, is the fundamental group of $UC^n \Gamma$. We use the methods and results of our paper "Discrete Morse theory and graph braid groups" to get a partial description of the cohomology rings $H^*(B_n T)$, where $T$ is a tree. Our results are then used to prove that $B_n T$ is a right-angled Artin group if and only if $T$ is linear or $n<4$. This gives a large number of counterexamples to Ghrist's conjecture that braid groups of planar graphs are right-angled Artin groups.Comment: 25 pages, 7 figures. Revised version, accepted by the Journal of Pure and Applied Algebr