The instability of humane greatness, [electronic resource] : illustrated and exemplified in a funeral discourse at Braintree April 23. 1738. Upon the much lamented death of the Honourable Edmund Quincy, Esq; one of His Majesty's Council, and of the judges of the circuit, and agent for the province of the Massachusetts Bay, at the court of Great Britain. Who died of the small pox in London the 23 of Febr. 1737,8. In the 57 year of his age. By John Hancock, A.M. and Pastor of the First Church in Braintree. [Five lines from Psalms].

Dedicated to Henry Flynt, and several others.Two states noted. In one, page numbers 8, 9 are misnumbered 10, 11; in the other, p. 10 is misnumbered 12."Addenda, from the Weekly journal, no. 574."--p. 31-[32].Signatures: [A]p4s(-[A]1) B-Dp4s Ep4s(-E4)Evans,Electronic reproduction.English Short Title Catalog,Reproduction of original from Library of Congress

Rebel Rebel, Art + Rock, (Revoltes Punk Section).

This major subject overview publication and exhibition traces the relationships between art and music from the twentieth century to the present. The book presents a chronology mapping a century from 1916 to 2016. I am included as one of many artists in the section Revoltes Punk: Art Roc

The miR-30 microRNA family targets smoothened to regulate hedgehog signalling in zebrafish early muscle development

The importance of microRNAs in development is now widely accepted. However, identifying the specific targets of individual microRNAs and understanding their biological significance remains a major challenge. We have used the zebrafish model system to evaluate the expression and function of microRNAs potentially involved in muscle development and study their interaction with predicted target genes. We altered expression of the miR-30 microRNA family and generated phenotypes that mimicked misregulation of the Hedgehog pathway. Inhibition of the miR-30 family increases activity of the pathway, resulting in elevated ptc1 expression and increased numbers of superficial slow-muscle fibres. We show that the transmembrane receptor smoothened is a target of this microRNA family. Our results indicate that fine coordination of smoothened activity by the miR-30 family allows the correct specification and differentiation of distinct muscle cell types during zebrafish embryonic development