A Nonlinear Approach to Open Space

This article traces the development of the Raleigh Greenway system. A nonlinear approach to greenway preservation evolved because of the existing institutional structure in Raleigh and the ever-changing greenway constituency. After considerable struggle, the greenway concept is now embraced in many communities across North Carolina and a simpler, more linear approach to creating greenways is in place

Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines

The objective of this study was to assess potential functional attenuation or inactivation of the intra-S checkpoint during melanoma development. Proliferating cultures of skin melanocytes, fibroblasts and melanoma cell lines were exposed to increasing fluences of UVC and intra-S checkpoint responses were quantified. Melanocytes displayed stereotypic intra-S checkpoint responses to UVC qualitatively and quantitatively equivalent to those previously demonstrated in skin fibroblasts. In comparison to fibroblasts, primary melanocytes displayed reduced UVC-induced inhibition of DNA strand growth and enhanced degradation of p21Waf1 after UVC, suggestive of enhanced bypass of UVC-induced DNA photoproducts. All nine melanoma cell lines examined, including those with activating mutations in BRAF or and NRAS oncogenes, also displayed proficiency in activation of the intra-S checkpoint in response to UVC irradiation. The results indicate that bypass of oncogene-induced senescence during melanoma development was not associated with inactivation of the intra-S checkpoint response to UVC-induced DNA replication stress

Law, Environment, and the “Nondismal” Social Sciences

Over the past 30 years, the influence of economics over the study of environmental law and policy has expanded considerably, becoming in the process the predominant framework for analyzing regulations that address pollution, natural resource use, and other environmental issues. This review seeks to complement the expansion of economic reasoning and methodology within the field of environmental law and policy by identifying insights to be gleaned from various “nondismal” social sciences. In particular, three areas of inquiry are highlighted as illustrative of interdisciplinary work that might help to complement law and economics and, in some cases, compensate for it: the study of how human individuals perceive, judge, and decide; the observation and interpretation of how knowledge schemes are created, used, and regulated; and the analysis of how states and other actors coordinate through international and global regulatory regimes. The hope is to provide some examples of how environmental law and policy research can be improved by deeper and more diverse engagement with social science

An Unusual Case of Multiple Mesosternal Foramina

We present an unusual example of multiple mesosternal foramina (MMF). The alignment of the paired defects is unlike any previously described. Although single sternal defects are often encountered, paired defects are quite uncommon. This is the first documented example of bilateral paired defects in the sternum

Labeling Emotional Faces Changes Affective Processing

<p>Differences between passive viewing, and labeling emotions portrayed by age appropriate actors in dynamic video stimuli.</p

Calendar of Virginia state papers and other manuscripts ...

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