The upgrade of the LHCb trigger system

The LHCb experiment will operate at a luminosity of $2\times10^{33}$ cm$^{-2}$s$^{-1}$ during LHC Run 3. At this rate the present readout and hardware Level-0 trigger become a limitation, especially for fully hadronic final states. In order to maintain a high signal efficiency the upgraded LHCb detector will deploy two novel concepts: a triggerless readout and a full software trigger.Comment: Proceedings of the Workshop on Intelligent Trackers, 14-16 May 2014, University of Pennsylvani

Measurement of the CP-violating phase φs in the decay Bo/s →J/ψ/φ

The LHCb experiment is dedicated to making precision measurements involving beauty and charm hadrons at the CERN Large Hadron Collider. The LHCb RICH detectors provide charged particle identification required to distinguish final states in many decays important to the LHCb physics programme. Time alignment of the RICH photon detectors is necessary in order to ensure a high photon collection efficiency. Using both a pulsed laser and proton-proton collision data the photon detectors are aligned to within 1 ns. The LHCb detector is uniquely positioned to measure production cross-sections at energies and rapidities inaccessible to other experiments. With 1.81 nb−1 of proton-proton collisions collected by the LHCb experiment in 2010 at center-of-mass energy √s = 7 TeV the production crosssection of D±s and D± mesons decaying to the φ{K+K−}π ± final state have been determined in bins of transverse momentum and rapidity. These measurements use a data-driven recursive optimisation technique to improve signal significance. The cross-section ratio is measured to be σ(D± ) σ(D± s ) = 2.32±0.27(stat)±0.26(syst), consistent with the ratio of charm-quark hadronisation fractions to D± and D±s mesons. Time-dependent interference between mixing of B0s -B0s mesons and decay to the final state J/ψφ gives rise to a CP violating phase φs. This phase is constrained to be small within the Standard Model, a significant deviation from which would be a signal of new physics. φs has been measured with 0.37 fb−1 of protonproton collision data recorded during 2011 by the LHCb experiment. Isolation of the signal distribution is achieved using the S-plot technique, and the analysis accounts for inclusive B0s →J/ψK+K− s-wave contributions. The measured value of φs = 0.16±0.18(stat)±0.06(syst) rad is the most precise measurement to date, and is consistent with Standard Model predictions

Exercise, type 1 diabetes mellitus and blood glucose: The implications of exercise timing

The scientific literature shows that exercise has many benefits for individuals with type 1 diabetes. Yet, several barriers to exercise in this population exist, such as post-exercise hypoglycaemia or hyperglycaemia. Several studies suggest that the timing of exercise may be an important factor in preventing exercise-induced hypoglycaemia or hyperglycaemia. However, there is a paucity of evidence solely focused on summarising findings regarding exercise timing and the impact it has on glucose metabolism in type 1 diabetes. This report suggests that resistance or high-intensity interval exercise/training (often known as HIIT) may be best commenced at the time of day when an individual is most likely to experience a hypoglycaemic event (i.e., afternoon/evening) due to the superior blood glucose stability resistance and HIIT exercise provides. Continuous aerobic-based exercise is advised to be performed in the morning due to circadian elevations in blood glucose at this time, thereby providing added protection against a hypoglycaemic episode. Ultimately, the evidence concerning exercise timing and glycaemic control remains at an embryonic stage. Carefully designed investigations of this nexus are required, which could be harnessed to determine the most effective, and possibly safest, time to exercise for those with type 1 diabetes

Component-resolved Near-infrared Spectra of the (22) Kalliope System

We observed (22) Kalliope and its companion Linus with the integral-field spectrograph OSIRIS, which is coupled to the adaptive optics system at the W.M. Keck II telescope on March 25 2008. We present, for the first time, component-resolved spectra acquired simultaneously in each of the Zbb (1-1.18 um), Jbb (1.18-1.42 um), Hbb (1.47-1.80 um), and Kbb (1.97-2.38 um) bands. The spectra of the two bodies are remarkably similar and imply that both bodies were formed at the same time from the same material; such as via incomplete re-accretion after a major impact on the precursor body.Comment: 20 pages, 5 figures, 1 table. Accepted for publication in Icaru

Affective and perceptual responses during reduced-exertion high-intensity interval training (REHIT)

We have previously demonstrated that reduced-exertion high-intensity interval training (REHIT) is a genuinely time-efficient exercise strategy for improving cardiometabolic health. Here, we examined the affective and perceptual responses to REHIT. Eight young men and women (age 21 ± 1 y, BMI 24.9 ± 2.1 m/kg2, V̇O2max 39 ± 10 ml/kg/min) and 11 men with type 2 diabetes (T2D; age 52 ± 6 y, BMI 29.7 ± 3.1 m/kg2, V̇O2max 29 ± 5 ml/kg/min) took part in three-arm crossover trials with RPE and affective valence measured during, and enjoyment and exercise preferences measured following either: 1) REHIT (2 × 20-s sprints in a 10-min exercise session), 2) HIIT (10 × 1-min efforts) and 3) 30 min MICT. Furthermore, 19 young men and women (age 25 ± 6 y, BMI 24 ± 4 m/kg2, V̇O2max 34 ± 8 ml/kg/min) completed a 6-week REHIT intervention with affective valence during an acute REHIT session measured before and after training. Affect decreases (briefly) during REHIT, but recovers rapidly, and the decline is not significantly different when compared to MICT or HIIT in either healthy participants or T2D patients. Young sedentary participants reported similar levels of enjoyment for REHIT, MICT and HIIT, but 7 out of 8 had a preference for REHIT. Conversely, T2D patients tended to report lower levels of enjoyment with REHIT compared with MICT. The decrease in affective valence observed during an acute REHIT session was significantly attenuated following training. We conclude that affective and perceptual responses to REHIT are no more negative compared to those associated with MICT or HIIT, refuting claims that supramaximal sprint interval training protocols are associated with inherent negative responses

Wearable chemical sensing – sensor design and sampling techniques for real-time sweat analysis

Wearable chemical sensors have the potential to provide new methods of non-invasive physiological measurement. The nature of chemical sensors involves an active surface where a chemical reaction must occur to elicit a response. This adds complexity to a wearable system which creates challenges in the design of a reliable long-term working system. This work presents the design of a real-time sweat sensing platform to analyse sweat loss and composition. Sampling methods have an impact on composition therefore skin encapsulation needs to be avoided so as not to disrupt normal sweating patterns. Sensors ideally need to be placed close to the sampling site which may be subject to motion artefacts [1]. The design of this device takes into account sample collection and delivery, sensor placement and associated electronics. The overall design is ergonomic to interface with the contours of the body. Results of lab-based simulations and real-time exercise trials are presented. This device can offer valuable information regarding hydration status and electrolyte balance which may be especially important for optimised rehydration during or after sports activities. [1] Curto, V. F. S. Coyle, R. Byrne, N. Angelov, D. Diamond, F. Benito-Lopez., Sens. Actuators, B, 2012, 175, 263-270

Structured exercise programs for higher education students experiencing mental health challenges: background, significance, and implementation

The incidence of mental illness is greatest among young adults, and those enrolled in higher education may be particularly vulnerable compared to the general young adult population. Many higher education institutions employ student support staff tasked with implementing strategies to improve student wellbeing and mental illness. However, these strategies tend to be focused on clinical therapies and pharmacological interventions with limited lifestyle approaches. Exercise is an effective method for addressing mental illness and promoting wellbeing, yet widespread provision of structured exercise services to support treatment options for students with mental health challenges has not been fully realized. In an effort to guide exercise strategies for student mental health, we synthesize considerations for developing and delivering exercise programs in higher education settings. We draw directly from the evidence base on existing exercise programs in higher education; and the broader behavior change, exercise adherence, health psychology, implementation science, and exercise prescription literatures. Our broad considerations cover issues regarding program engagement and behavior change, exercise ‘dose’ and prescription, integration with other on-campus services, and robust research and evaluation. These considerations may provide impetus for widespread program development and implementation, as well as informing research focused on protecting and improving student mental health

Tuberculosis joint infections in four domestic cats

Case series summary This paper describes the clinical presentation, diagnostic imaging findings and outcome in four cats with confirmed joint-associated tuberculosis. The cats were 2–6 years of age, and immune competent. Three cases had tuberculosis affecting only one joint, whereas one case had at least three joints affected. Two cases were caused by Mycobacterium bovis , and the other two were caused by Mycobacterium microti . Radiological findings included osteolysis, periosteal reaction and associated soft tissue swelling. Two cases were euthanased and two cases responded well to amputation and follow-on antibiotic therapy. Relevance and novel information To our knowledge, this is the first publication of a series of cats with joint-associated tuberculosis. Although tuberculosis is not common, a high degree of suspicion is needed to avoid delayed diagnosis. This case series highlights the importance of considering mycobacterial disease as a differential for joint disease in cats