A Search for Binary Stars at Low Metallicity

We present initial results measuring the companion fraction of metal-poor stars ([Fe/H]$<-$2.0). We are employing the Lick Observatory planet-finding system to make high-precision Doppler observations of these objects. The binary fraction of metal-poor stars provides important constraints on star formation in the early Galaxy (Carney et al. 2003). Although it has been shown that a majority of solar metallicity stars are in binaries, it is not clear if this is the case for metal-poor stars. Is there a metallicity floor below which binary systems do not form or become rare? To test this we are determining binary fractions at metallicities below [Fe/H]$=-2.0$. Our measurments are not as precise as the planet finders', but we are still finding errors of only 50 to 300 m/s, depending on the signal-to-noise of a spectrum and stellar atmosphere of the star. At this precision we can be much more complete than previous studies in our search for stellar companions.Comment: To appear in conference proceedings,"First Stars III", eds. B. O'Shea, A. Heger & T. Abel. 3 pages, 5 figure

Women Religious in a Changing Urban Landscape: The Work of Catholic Sisters in Metropolitan Cleveland

In many communities, women religious play a vital role in addressing the needs of the poor, neglected, and vulnerable members of society. Catholic Sisters have long been active in the areas of education, health care, outreach, and advocacy in northeast Ohio. In high-poverty urban areas such as Cleveland, women religious continue to provide essential services, support, and spiritual guidance. The experience in Cleveland is relevant to other cities where the population has shifted from an urban center to suburban areas, leaving inner-city churches with declining membership and support. Survey data collected from 164 Catholic Sisters from fifteen religious orders in Cleveland and the surrounding area illuminate the characteristics of Sisters� ministries and suggest ways in which proactive and collaborative efforts can enhance the provision of services now and in the future

No legitimacy: A study of private sector sanitation development in the Global South

What is needed for the private sector to successfully establish itself as a key player in delivering sustainable sanitation in the Global South? The present paper aims to offer some answers to this through the case of Peepoople AB, a company delivering a single-use biodegradable toilet bag in informal settlements. The company aimed to but failed in combining sustainable development of sanitation and financial gain for investors. We suggest that explanations for the failure can be found in the interaction between the company and the development– and aid organisations already involved in sanitation development. Through Strategic Niche Management, we look at whether the company managed to create relevant social networks, expectation dynamics and learning processes. The company gained legitimacy with end users, but failed to gain legitimacy in the development sector as it did not prioritise the kind of learning and competence considered relevant in the sector

Exoplanet Detection Techniques

We are still in the early days of exoplanet discovery. Astronomers are beginning to model the atmospheres and interiors of exoplanets and have developed a deeper understanding of processes of planet formation and evolution. However, we have yet to map out the full complexity of multi-planet architectures or to detect Earth analogues around nearby stars. Reaching these ambitious goals will require further improvements in instrumentation and new analysis tools. In this chapter, we provide an overview of five observational techniques that are currently employed in the detection of exoplanets: optical and IR Doppler measurements, transit photometry, direct imaging, microlensing, and astrometry. We provide a basic description of how each of these techniques works and discuss forefront developments that will result in new discoveries. We also highlight the observational limitations and synergies of each method and their connections to future space missions.Comment: 24 pages, 19 figures, PPVI proceedings. Appears as 2014, Protostars and Planets VI, Henrik Beuther, Ralf S. Klessen, Cornelis P. Dullemond, and Thomas Henning (eds.), University of Arizona Press, Tucson, 914 pp., p.715-73

“Do not look at me like that”: Is the facial expression score reliable and accurate to evaluate pain in large domestic animals? A systematic review

Introduction: Facial expression scoring has proven to be useful for pain evaluation in humans. In the last decade, equivalent scales have been developed for various animal species, including large domestic animals. The research question of this systematic review was as follows: is facial expression scoring (intervention) a valid method to evaluate pain (the outcome) in large domestic animals (population)? Method: We searched two databases for relevant articles using the search string: “grimace scale” OR “facial expression” AND animal OR “farm animal” NOT “mouse” NOT “rat” NOT “laboratory animal.” The risk of bias was estimated by adapting the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) checklist. Results: The search strategy extracted 30 articles, with the major share on equids and a considerable number on cows, pigs, and sheep. Most studies evaluated facial action units (FAUs), including the eye region, the orbital region, the cheek or the chewing muscles, the lips, the mouth, and the position of the ears. Interobserver reliability was tested in 21 studies. Overall FAU reliability was substantial, but there were differences for individual FAUs. The position of the ear had almost perfect interobserver reliability (interclass coefficient (ICC): 0.73–0.97). Validity was tested in five studies with the reported accuracy values ranging from 68.2 to 80.0%. Discussion: This systematic review revealed that facial expression scores provide an easy method for learning and reliable test results to identify whether an animal is in pain or distress. Many studies lack a reference standard and a true control group. Further research is warranted to evaluate the test accuracy of facial expression scoring as a live pen side test

Muscarinic signaling influences the patterning and phenotype of cholinergic amacrine cells in the developing chick retina

<p>Abstract</p> <p>Background</p> <p>Many studies in the vertebrate retina have characterized the differentiation of amacrine cells as a homogenous class of neurons, but little is known about the genes and factors that regulate the development of distinct types of amacrine cells. Accordingly, the purpose of this study was to characterize the development of the cholinergic amacrine cells and identify factors that influence their development. Cholinergic amacrine cells in the embryonic chick retina were identified by using antibodies to choline acetyltransferase (ChAT).</p> <p>Results</p> <p>We found that as ChAT-immunoreactive cells differentiate they expressed the homeodomain transcription factors Pax6 and Islet1, and the cell-cycle inhibitor p27^kip1. As differentiation proceeds, type-II cholinergic cells, displaced to the ganglion cell layer, transiently expressed high levels of cellular retinoic acid binding protein (CRABP) and neurofilament, while type-I cells in the inner nuclear layer did not. Although there is a 1:1 ratio of type-I to type-II cells <it>in vivo</it>, in dissociated cell cultures the type-I cells (ChAT-positive and CRABP-negative) out-numbered the type-II cells (ChAT and CRABP-positive cells) by 2:1. The relative abundance of type-I to type-II cells was not influenced by Sonic Hedgehog (Shh), but was affected by compounds that act at muscarinic acetylcholine receptors. In addition, the abundance and mosaic patterning of type-II cholinergic amacrine cells is disrupted by interfering with muscarinic signaling.</p> <p>Conclusion</p> <p>We conclude that: (1) during development type-I and type-II cholinergic amacrine cells are not homotypic, (2) the phenotypic differences between these subtypes of cells is controlled by the local microenvironment, and (3) appropriate levels of muscarinic signaling between the cholinergic amacrine cells are required for proper mosaic patterning.</p

Multicultural Counselor Supervision and Perceived Differences on Client Outcome

The purpose of this study was to examine the differences between counselor supervisors’ and supervisees’ perceptions of the impact of multicultural supervision on client outcome. Counselor supervisors and supervisees may have differences in how much they believe multicultural factors affect client outcome and this study aimed to determine what differences exist. There were 61 participants in the study consisting of faculty, counselor supervisors, counselors, and graduate students in counseling-related fields. The current study found that multicultural supervision/competence alone predicted supervisor perceptions of client outcome. The findings suggest that training in supervision and multicultural supervision is vital to the professional development of counselors and trainees in counseling- related fields. This training is also necessary because of the impact it has on clients. The implications of this study highlight the need to improve the knowledge of those in counseling-related fields as to the importance of multicultural counseling and competence in training

Unraveling the genomic diversity of small eukaryotes

A report of the meeting Comparative Genomics of Eukaryotic Microorganisms, 17-22 October 2009, San Feliu de Guixols, Spain

Seasonal variability of resources : The unexplored adversary of biogas use in rural Ethiopia

Funding This project was funded by (BBSRC BB/M010996/1) and the University of Aberdeen. AF’s contribution was supported by UKRI (ES/P002501/1). JS’s contribution was supported by UKRI (ES/P002501/1) and DFID NEXUS (NE/P004830). Acknowledgements We would like to thank Hawassa University and the Southern Agricultural Research Institute for their support with organisation, data collection and translation.Peer reviewedPublisher PD