Supravegherea antenatală – un program important în diminuarea riscurilor perinatale

Background. Antenatal medical surveillance (AMS) is a coordinated program, with a specific algorithm for medical and psychological care of the pregnant woman (PW), which contributes to reducing perinatal risks. Objective of the study. To appreciate the effectiveness of the antenatal care (ANC) process of PW. Material and Methods. We performed a prospective study based on a questionnaire, on 359 women at AMS, in the administrative territories of the Republic of Moldova (RM) during 2019. Data were processed with the software SPSS Statistics V23. Results. The average age of PW was 27 years ( 0.2), from which 56,4% had higher education (HE). In 82,0% cases pregnancy was planned and in 61,1% the express pregnancy test was the primary diagnostic method. Up to 12 weeks of pregnancy, 91.1% of women were at AMS; 7 medical ANC visits were done in 52.4% of cases. Women with HE complied with the provisions and uptakes of routine antenatal services (PURAS) in 84.6%, those with secondary education - in 51.3%, and the high school graduated ones in 40.2%. ANC visits were performed by 75.4% primiparous women and by 53.6% of the secundiparous ones. Blood pressure was checked by the doctor in 73.2%, the body mass index – calculated in 80.0%. The an Conclusion. This study showed a high rate of early AMS in PW in the Republic of Moldova, but also their failure to fully comply with the PURAS and shortcomings when providing ANC services. Introducere. Supravegherea antenatală este un program coordonat, cu un algoritm specific de îngrijire medicală și psihologică a gravidei, care contribuie la diminuarea riscurilor perinatale. Scopul lucrării. Aprecierea eficacității desfășurării procesului de îngrijire antenatală (ÎA) a gravidelor. Material și Metode.. A fost efectuat un studiu prospectiv, în baza unui chestionar, la 359 femei aflate la evidență antenatală (EA), în teritoriile administrative ale Republicii Moldova (RM), pe parcursul anului 2019. Procesarea datelor a avut loc prin software-ul SPSS Statistics V23. Rezultate. . Vârsta medie a gravidelor a constituit 27 ani ( 0,2); cu studii superioare (SS) au fost 56,4%. Sarcina a fost planificată în 82,0% de cazuri, metoda primară de diagnostic - test-express (61,0%). Până la 12 săptămâni la evidența medicală au fost înregistrate 91,1% gravide; 7 vizite obligatorii (VO) la medic au avut loc în 52,4 % cazuri. Femeile cu SS au respectat prevederile programului (PP) în 84,6%, cele cu studii medii - în 51,3%, liceale – 40,2%. VO au fost efectuate de 75,4% primipare și de 53,6% secundipare. De către medic tensiunea arterială a fost apreciată la 73,2% femei, indicele masei corporale – calculat la 80,0 % din gravide, screeningul creșterii antenatale - efectuat în 64,8. Concluzii. Studiul a relevat o rată înaltă a stabilirii precoce la EA a gravidelor din Republica Moldova, nerespectarea tuturor PP de către ele, dar și neajunsuri în prestarea serviciilor de ÎA de către personalul medical

Vacuum therapy in the treatment of purulent wounds

Department of General Surgery and Semiology no.3, Municipal Clinical Hospital no.1, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of MoldovaIntroduction. Negative pressure wound treatment (NPWT) consists of applying a special dressing to the internal wound’s environment, controlled by subatmospheric pressure. Sterile sponges with an impermeable membrane connected to a pump delivering subatmospheric pressure are applied to wound’s edges. The sponges don’t allow bacteria to multiply, and lead to reducing wound’s size until healing occurs. Aim of the study. To evaluate the NPWT benefits in purulent wounds treatment. Materials and methods. The study was based on 19 cases presented with various purulent wounds of soft tissues treated at the Department of General Surgery, Municipal Clinical Hospital No.1 (Chisinau). There were 12 (63.15%) male and 7 (36.85%) female patients. Age of subjects varied between 32 and 76 years. The NPWT system was used if local signs of wound suppuration during its surgical secondary processing were noticed. Patients were treated under local or general intravenous anesthesia, in aseptic conditions. After the removing of sutures, hydrogen peroxide was used, necrotic masses – removed, and hemostasis – applied. Then a piece of sterile sponge was adjusted and installed into the wound channel. External tip of a tube, placed inside the sponge, exiting through a separate incision. The wound was partially sutured. Wound’s edges were treated with alcohol solution, and then dried. Hermetic film was then applied to cover the wound. The drain was connected to the NPWT system set at the pressure of -125 to -75 mm Hg. The dressings were changed once every 72 hours. During the application of another dressing, the sponge and the previously installed system was removed from the wound, examining the persistence of the necrotic masses. The state of the granulation tissue was also checked. The number of sessions depended on the above listed findings. In the absence of necrotic masses and pathological discharge secondary sutures were applied. Results. In 3 (15.8%) cases dressings were changed only 2 times – enough for granulation tissue appearance. Twelve (63.15%) patients required 4 and another four (21%) – 6 sessions (exchanges of NPWT system) until sufficient proliferation of the granulation tissue. Conclusions. We proved the usefulness of NPWT system that has been able to prepare the wounds to secondary sutures applying. Vacuum therapy in the treatment of purulent wounds is associated with shorter period of hospitalization and more effective pain management

Antenatal surveillance - an important program in reducing perinatal risk

Department of Obstetrics and Gynecology, SUMPh “Nicolae Testemițanu”, Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareIntroduction. Antenatal medical surveillance (AMS) is a coordinated program, with a specific algorithm for medical and psychological care of the pregnant woman, which contributes to reducing perinatal risks. Purpose. To appreciate the effectiveness of the antenatal care (ANC) process of pregnant women. Material and methods. We performed a prospective study based on a questionnaire, on 359 women at AMS, in the administrative territories of the Republic of Moldova during 2019. Data were processed with the software SPSS Statistics V23. Results. The average age was 27 years, from which 56,4% had higher education (fig.1). In 82,0% cases pregnancy was planned and in 61,1% the express pregnancy test was the primary diagnostic method. Up to 12 weeks of pregnancy, 91.1% of women were at AMS; 7 medical ANC visits were done in 52.4% of cases (tab.1). Women with higher education complied with the provisions and uptakes of routine antenatal services (PURAS) in 84.6%, those with secondary education - in 51.3%, and the high school graduated ones in 40.2%. ANC visits were performed by 75.4% primiparous women and by 53.6% of the secundiparous ones. Blood pressure was checked by the doctor in 73.2%, the body mass index - calculated in 80.0%. Conclusions. This study showed a high rate of early antenatal medical surveillance in pregnant woman in the Republic of Moldova, but also their failure to fully comply with the PURAS and shortcomings when providing ANC service

LABOR INDUCTION WITH A FOLEY CATHETER IN PREGNANCIES WITH A TENDENCY FOR PROLONGATION

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. Inducerea travaliului (IT) este o intervenție obstetricală comună care stimulează debutul sarcinii folosind diverse tehnici medicale. Indicațiile pentru IT variază în funcție de termenul sarcinii, anamneza obstetricală și medicală a gravidei. În sarcinile cu tendință de suprapurtare, una din tehnicile utilizate pentru IT este aplicarea cateterului Foley. Scopul lucrării. Aprecierea eficacității inducerii travaliului cu ajutorul cateterului Foley în sarcinile cu tendință de prolongare. Material și metode. A fost efectuată o analiză retrospectivă a inducerii travaliului cu ajutorul cateterului Foley la femeile cu termenul sarcinii 41-42 săptămâni, care au născut în Institutul Mamei și Copilului. Studiul s-a efectuat pe un lot de 52 gravide la care scorul Bishop era mai mic de 6. Pentru procesarea datelor, a fost utilizat SPSS versiunea 23. Rezultate. Au fost studiate 52 cazuri de sarcină cu tendință de suprapurtare, la care travaliul a fost indus cu ajutorul unui cateter Foley. Vârsta medie a gravidelor a fost 29,3 ani. Primiparele au constituit 63,5 % (33). S-a observat că la 11 femei (21,2 %), cateterul Foley a contribuit la începerea travaliului în primele 24 ore. La alte 25 % (13) gravide, travaliul a debutat în decurs de 48 ore. În 55,8% cazuri (29 femei) au folosite metode suplimentare pentru inducerea travaliului (amniotomie, misoprostol, oxitocină). În 26,9% nașterea s-a finalizat prin operație cezariană. La femeile multipare, a fost observată o rată mai înaltă a debutului travaliului (54,5%) după aplicarea cateterului Foley. Concluzii. Utilizarea cateterului Foley pentru inducerea travaliului în sarcinile cu tendință de prolongare este o metoda simplă și eficientă. La multipare, s-a observat o rată mai înaltă a debutului travaliului comparativ cu primi parele. Sarcina s-a finalizat prin operație cezariană prepon derent la primipare.Introduction. Induction of labor (IoL) is a common obstetric intervention that stimulates the onset of pregnancy using various medical techniques. Indications for IoL vary depending on the term of pregnancy, obstetrical and medical history of the pregnant woman. In pregnancies with a tendency for prolongation, one of the techniques used for IoL consists in application of a Foley catheter. Aim of study. To assess the effectiveness of labors’s induction using a Foley catheter in pregnancies with a tendency to prolongation. Material and methods. A retrospective analysis based on IoL with the help of a Foley catheter in women at 41-42 weeks of gestation who delivered in IMC was performed. The study was conducted on a group of 52 pregnant women who’s Bishop Score was less than 6. SPSS version 23 was used for data processing. Results. Fifty two cases of pregnancy with a tendency to prolongation, in which labor was induced with a Foley catheter, were studied. The mean age of the pregnant women was 29.3. Primiparous constituted 63.5% (33). It was noted that in 11 women (21.2%), the Foley catheter contributed to the onset of labor within the first 24 hours. In another 25% (13) of pregnant women, labor started within 48 hours. In 55.8% cases (29 women) additional methods were used to induce labor (amniotomy, misoprostol, and oxytocin). In 26.9%, the birth was completed by caesarean section. In multiparous women, a higher rate of onset of labor (54.5%) was observed after Foley catheter placement. Conclusions. Using a Foley catheter for induction of labor in pregnancies with a tendency to prolongation is a simple and effective method. In multiparous, a higher rate of labor’s onset was observed compared to primiparous. The pregnancy was completed by caesarean section mainly in primiparous cases

Influența infecției cu virusul SARS-COV-2 asupra ratei mortalității materne în Republica Moldova

Background. Starting with March 2020 until March 2022, 513442 cases of COVID-19 and 11431 deaths were reported in the Republic of Moldova (RM), corresponding to a mortality rate of 2.2%. In the RM, from 19 deaths among pregnant women, 13 were COVID-19 - associated. Objective of the study. To analyze the influence of SARS-CoV-2 infection on maternal mortality in the Republic of Moldova. Material and methods: A retrospective monitoring study based on maternal mortality (MM) in the Republic of Moldova during 2020-2021 was undertaken, regarding COVID-19 cases in pregnant women. For data processing, SPSS version 10 was used. Results. Ten cases of death (68%) among pregnant women with severe forms of COVID-19 have been studied. The average age of the patients was 29.6 years. The primiparous/secundiparous ratio was 1:1. In 70% of women, pre-existing pregnancy diseases were found. Over 30% of the patients were overweight. No woman was vaccinated against SARS-CoV-2 and none had COVID before pregnancy. Death occurred in postpartum women in 80%. From the onset of the first symptoms until death, an average of 21,3 days passed. In all the cases, the disease was complicated with sepsis, MODS, pulmonary embolism, and cardio-respiratory arrest. Conclusion. It can be noted that the MM rate in Moldova has increased essentially during the COVID-19 pandemic. This can be explained by: the high contagiousness of the disease, mainly in 2021 (10 deaths), a low vaccination rate among pregnant women and delayed referral to medical services.Introducere: În Republica Moldova (RM), din martie 2020 până în martie 2022, au fost raportate 513442 cazuri de COVID-19 și 11431 decese, ceea ce corespunde unei rate de mortalitate de 2,2 %. În RM, din totalul de 19 decese în rândul femeilor însărcinate, 13 au fost COVID-19 - asociate. Scopul lucrării: Studierea influenței infecției cu virusul SARS-CoV-2 asupra mortalității materne în RM. Materiale și metode: A fost efectuat un studiu de monitorizare retrospectivă a mortalității materne (MM) din RM în perioada anilor 2020-2021, în legătură cu cazurile de COVID-19 la femeile însărcinate. Pentru procesarea datelor, a fost utilizat SPSS versiunea 10. Rezultate: Au fost studiate 10 cazuri de deces (68%) în rândul femeilor gravide, cu forme grave de COVID-19 .Vârsta medie a pacientelor a constituit 29,6 ani. Raportul primipare/secundipare a fost de 1:1. La 70% femei, au fost constatate maladii preexistente sarcinii. Peste 30% din paciente au fost supraponderale. Nici o femeie nu a fost vaccinată împotriva SARS-CoV-2 și anterior sarcinii nu a suportat boala. Decesul a survenit în perioada de lăuzie în 80%. De la debutul primelor simptome până la deces, în mediu au trecut 21,3 zile. În toate cazurile, maladia s-a complicat cu sepsis, MODS, TEAP și stop cardio-respirator. Concluzie: Se poate constata că rata MM în RM a crescut esențial în timpul pandemiei COVID-19. Aceasta poate fi explicată prin: contagiozitatea înaltă a maladiei, preponderent în anul 2021 (10 decese), a ratei mici de vaccinare în rândul gravidelor și adresarea întârziată la serviciile medicale

The impact of endometriosis on in vitro fertilization outcomes

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. Endometrioza este o maladie inflamatorie definită prin prezența țesutului endometrial în afara cavității uterine, care afectează 10-15% din populația feminină. Ea este o cauză majoră a infertilității prin diferite mecanisme. Endometrioza este asociată cu rezerva ovariană diminuată, deseori iatrogen, după chistectomii repetate, răspuns slab la stimularea ovariană, ovocite și embrioni de calitate scăzută, cauzate de prezența în lichidul peritoneal al citokinelor proinflamatorii, receptivitate endometrială alterată și rate scăzute ale sarcinii spontane sau obținute prin fertilizare in vitro (FIV). Scopul lucrării. Evaluarea impactul endometriozei asupra succesului FIV. Material și metode. A fost realizat un studiu bibliografic pentru ultimii 5 ani, fiind căutate îmbinările de cuvinte: „endometriosis” și „in vitro fertilization” în motorul de căutare disponibil gratuit, open-acces – Google Scholar. Ca rezultat au apărut peste 50 de surse. Din ele au fost analizate 20 de surse, care au fost relevante tematicii, incluzând toate aspectele puse în discuție. Rezultate. Nivelul Hormonului antimullerian (AMH) a scăzut chiar și în absența intervenției chirurgicale până la 26,4% în jumătate de an la femeile cu chisturi endometriale. La aceste femei s-au obținut un număr mai mic de ovocite și embrioni și rată mai mare de avort spontan. Manifestările clinice au fost în corelație cu severitatea maladiei și au fost explicate prin răspunsul inflamator pelvian și stresul oxidativ. Rata de apariție a sarcinii a fost mai mică la pacientele cu endometrioză deseori din cauza exacerbării patologiei. Concluzii. Endometrioza este una din cele mai comune patologii cu impact negativ asupra fertilității feminine. Procedura FIV la pacientele cu endometrioza necesită doze mai mari de gonadotropine și timp mai mult de stimulare ovariană.Introduction. Endometriosis is an inflammatory disease defined by the presence of endometrial tissue outside the uterine cavity, affecting 10-15% of the female population. It is a major cause of infertility through various mechanisms. Endometriosis is associated with diminished ovarian reserve, often iatrogenic, consequence of repeated cystectomies, poor response to ovarian stimulation, low-quality oocytes and embryos, presence of proinflammatory cytokines in the peritoneal fluid, altered endometrial receptivity and low rates of spontaneous or conceived through in vitro fertilization (IVF) pregnancies. Objective of the study. Evaluation of endometriosis’ impact on IVF efficacy. Materials and Methods: It was accomplished a bibliographic study, including material published within the last 5 years, by searching for word combinations: „endometriosis” and „in vitro fertilization” in the free, open-access search engine - Google Scholar. As a result, more than 50 sources have appeared, from which 20 (more relevant, including all discussed aspects of the topic) - were analyzed. Results. The level of Anti-Mullerian Hormone (AMH) has decreased even in the absence of surgery up to 26.4% in half a year in women with endometrial cysts. These women had a lower number of oocytes and embryos and a higher rate of spontaneous abortions. The clinical manifestations were correlated with the severity of the disease and were explained by the pelvic inflammatory response and oxidative stress. The pregnancy rate was lower in patients with endometriosis often due to exacerbation of the pathology. Conclusions. Endometriosis is one of the most common pathologies with a negative impact on female fertility. The IVF procedure in patients with endometriosis requires higher doses of gonadotropins and longer ovarian stimulation time

INFLUENCE OF SARS-COV-2 INFECTION ON MATERNAL MORTALITY RATE IN THE REPUBLIC OF MOLDOVA

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere: În Republica Moldova (RM), din martie 2020 până în martie 2022, au fost raportate 513442 cazuri de COVID-19 și 11431 decese, ceea ce corespunde unei rate de mortalitate de 2,2 %. În RM, din totalul de 19 decese în rândul femeilor însărcinate, 13 au fost COVID-19 - asociate. Scopul lucrării: Studierea influenței infecției cu virusul SARS-CoV-2 asupra mortalității materne în RM. Materiale și metode: A fost efectuat un studiu de monitorizare retrospectivă a mortalității materne (MM) din RM în perioada anilor 2020-2021, în legătură cu cazurile de COVID-19 la femeile însărcinate. Pentru procesarea datelor, a fost utilizat SPSS versiunea 10. Rezultate: Au fost studiate 10 cazuri de deces (68%) în rândul femeilor gravide, cu forme grave de COVID-19 .Vârsta medie a pacientelor a constituit 29,6 ani. Raportul primipare/secundipare a fost de 1:1. La 70% femei, au fost constatate maladii preexistente sarcinii. Peste 30% din paciente au fost supraponderale. Nici o femeie nu a fost vaccinată împotriva SARS-CoV-2 și anterior sarcinii nu a suportat boala. Decesul a survenit în perioada de lăuzie în 80%. De la debutul primelor simptome până la deces, în mediu au trecut 21,3 zile. În toate cazurile, maladia s-a complicat cu sepsis, MODS, TEAP și stop cardio-respirator. Concluzie: Se poate constata că rata MM în RM a crescut esențial în timpul pandemiei COVID-19. Aceasta poate fi explicată prin: contagiozitatea înaltă a maladiei, preponderent în anul 2021 (10 decese), a ratei mici de vaccinare în rândul gravidelor și adresarea întârziată la serviciile medicale.Background. Starting with March 2020 until March 2022, 513442 cases of COVID-19 and 11431 deaths were reported in the Republic of Moldova (RM), corresponding to a mortality rate of 2.2%. In the RM, from 19 deaths among pregnant women, 13 were COVID-19 - associated. Objective of the study. To analyze the influence of SARS-CoV-2 infection on maternal mortality in the Republic of Moldova. Material and methods: A retrospective monitoring study based on maternal mortality (MM) in the Republic of Moldova during 2020-2021 was undertaken, regarding COVID-19 cases in pregnant women. For data processing, SPSS version 10 was used. Results. Ten cases of death (68%) among pregnant women with severe forms of COVID-19 have been studied. The average age of the patients was 29.6 years. The primiparous/secundiparous ratio was 1:1. In 70% of women, pre-existing pregnancy diseases were found. Over 30% of the patients were overweight. No woman was vaccinated against SARS-CoV-2 and none had COVID before pregnancy. Death occurred in postpartum women in 80%. From the onset of the first symptoms until death, an average of 21,3 days passed. In all the cases, the disease was complicated with sepsis, MODS, pulmonary embolism, and cardio-respiratory arrest. Conclusion. It can be noted that the MM rate in Moldova has increased essentially during the COVID-19 pandemic. This can be explained by: the high contagiousness of the disease, mainly in 2021 (10 deaths), a low vaccination rate among pregnant women and delayed referral to medical services

Impactul tratamentului targetat în limfoamele Non-Hodgkin cu afectarea primară a ganglionilor limfatici

Hematology Discipline, Nicolae Testemitanu SUMPhBackground. Non-Hodgkin's lymphomas (NHL) are malignant hematopoietic tumors that develop from lymphoid tissue. Primary lymph node involvement (l/n) is the most common localization of it, summing 52-70%. The integration of Rituximab (R) in combination with conventional polychemotherapy (PChT) in the NHL treatment. Objective of the study. To evaluate the therapeutic impact of the use of R in combination with conventional PChT in the treatment of nodal onset NHL. Material and Methods. A descriptive cohort study was performed, which included 80 patients diagnosed with NHL monitored at the PMSI Oncological Institute. Statistical processing of materials was performed using Microsoft Excel and IBM SPSS statistics v.26. Results. In the study participated: men-39, women-41. The mean age of the patients was 56.09±13.6 years. The onset of NHL occurred in peripheral l/n in 85.0% of cases, in mediastinal l/n-7.5%, and in abdominals in 7.5%. Stages I-II were determined in 21(26.2%) patients, stages III-IV in 59(73.7%) cases. Aggressive NHLs were diagnosed in 52(65.0%) patients, indolent NHLs in 28(35.0%) cases. In 61(76.3%) patients, first-line R+PChT treatment was applied-group 1(G1), and in 19(23.8%) cases conventional PChT was applied-group 2(G2). The overall response rate(ORR) in G1 was 86.8%, in G2-63.1%. Complete remissions (CR) were obtained in G1 in 63.9% of patients in G2-47.3% of cases. Conclusion. The use of Rituximab increased the ORR rate (86.8% vs. 63.1%), the frequency of CR (63.9% vs. 47.3%) and PFS (20 months vs. 12 months (p <0.05)).Introducere. Limfoamele non-Hodgkin (LNH) reprezintă tumori hematopoietice maligne ce se dezvoltă din țesutul limfoid. Afectarea primară a ganglionilor limfatici (gl) este cea mai frecventă localizare, însumând 52-70%. Integrarea în tratamentul LNH al Rituximabului (R) în asociere cu polichimioterapia. Scopul lucrării. Evaluarea impactului terapeutic al utilizării R în asociere cu PChT convențională în tratamentul LNH cu debut nodal. Material și Metode. A fost efectuat un studiu descriptiv de cohortă unde au fost incluși 80 de pacienți cu diagnosticul de LNH monitorizați în cadrul IMSP Institutul Oncologic. Procesarea statistică a materialelor a fost efectuată cu utilizarea Microsoft Excel și IBM SPSS statistics v.26. Rezultate. În lotul de studiu bărbați au fost – 39, femei – 41. Vârsta medie a pacienților a constituit 56,09±13,6 ani. Debutul LNH a avut loc în gl periferici în 85,0% de cazuri, în mediastin – 7,5% și gl abdominali – 7,5%. Stadiile I-II au fost determinate la 21(26,2%) de pacienți, stadiile III-IV în 59 (73,7%) cazuri. LNH agresive au fost diagnosticate la 52(65,0%) de pacienți, LNH indolente în 28(35,0%) de cazuri. La 61(76,3%) de pacienți s-a aplicat tratamentul de prima linie R+PChT– lotul 1(L1), iar în 19 (23,8%) cazuri PChT convențională–lotul 2(L2). Rata generală de răspuns (ORR) în L1 a constituit 86,8%, în L2 –63,1%. Remisiuni complete (RC) au fost obținute în L1 la 63,9% pacienți, în L2 – 47,3% cazuri. Concluzii. Utilizarea de Rituximab a crescut rata de ORR (86,8% vs. 63,1%), frecvența RC (63,9% vs. 47,3%) și SFP (20 luni vs. 12 luni (p<0,05))

Impact of targeted treatment in non-Hodgkin’s lymphoma with primary lymph node involvement

Discipline of Hematology, Nicolae Testemitanu State University of Medicine and Pharmacy, Department of Hematology, Institute of Oncology, Chisinau, the Republic of MoldovaBackground: Non-Hodgkin’s lymphomas (NHL) are malignant tumors that develop from lymphoid tissue. Primary lymph node (LN) involvement is the most common localization (52-70%). The integration of Rituximab (R) in the NHL treatment represented a turning point. The aim of this study was to evaluate the therapeutic impact of the use of R in combination with conventional polychemotherapeutic (PChT) in the treatment of nodal onset NHL. Material and methods: A descriptive cohort study was performed on 80 patients diagnosed with NHL. Results: In the study participated: men – 39(48.8%), women – 41(51.2%). The mean age of the patients was 56.09 ± 13.6 years. The onset of NHL occurred in peripheral l/n in 85.0% of cases, in mediastinal LN – 7.5%, and abdominals in 7.5%. Stages I-II were identified in 21(26.2%) patients, stages III-IV in 59(73.8%) cases. Aggressive NHLs were diagnosed in 54(67.5%) patients, indolent NHLs in 26(32.5%) cases. In 61(76.3%) patients, first-line R+PChT treatment was applied – group 1(G1), and in 19(23.8%) cases conventional PChT was applied – group 2(G2). The overall response rate (ORR) in G1 was 86.8%, in G2 – 63.1%. Complete remissions (CR) were obtained in G1 in 63.9% of patients, in G2 – 47.3% of cases. Progression-free survival (PFS) in G1 had a median of 20 months, and in G2 the median was 12 months (p <0.05). Conclusions: The use of Rituximab increased the ORR rate (86.8% vs 63.1%), the frequency of CR (63.9% vs 47.3%) and PFS (20 months vs 12 months (p <0.05)