Educational potential specialists of customs authorities

The article analyzes the current state of the educational potential of the officials of the Tver customs. Prospective possibilities of development in the vocational education system of customs

RESEARCH OF POLITICAL COMMUNICATIONS: THE STATE AND SOCIAL MEDIA

Social media are widely used by politicized audience and politicians. The article examines the problems of interaction between the state and society on social media. The paper highlights the policy of the Russian state aimed at both stimulating the use of new communication tools and controlling them. It is demonstrated that social media are neutral and the way they display depends on their acquired qualities in the certain political system

Economic concept of food development of Russian market

At present, the Russian economy is developing in the conditions of imposed sanctions on high-tech means of production by foreign countries. In this situation, the development vector is the formation of import substitution policies and the solution of food safety issues for various types of food products that are strategically important for human life. Meeting the needs of the country's population with its own production is a priority for the development of the agrarian market, which makes it possible to develop the production agrarian sector, the processing and trade sphere, to create additional jobs, thereby improving the quality and standard of living of people.peer-reviewe

The influence of the concentration of montmorillonite containing sorbent and pH of the culture medium on the antibiotic sensitivity of Escherichia coli, as well as the effect of ground on growth of Escherichia

The aim of this work was the comparative sensitivity test of E. coli to enrofloxacin and doxycycline and bactericidal action of montmorillonite containing sorbent and its combination with enrofloxacin, as well as the influence of the concentration of the enriched montmorillonite containing sorbent and pH of the culture medium on the antibiotic sensitivity of Escherichia coli. The sensitivity test of Escherichia coli to enrofloxacin, and the combination of enrofloxacin with sorbent was performd by the method of double serial dilutions of drugs in a liquid culture mediu

Comparative Analysis of the Legal Regulation of Civil Liability for Harm Caused to Human Life and Health

The purpose of this article is a comparative analysis of the legal regulation of civil liability for harm caused to human life and health by activities that create an increased danger to others in Russia and foreign countries. Due to the intensive development of new technologies and the emergence of new sources of increased danger, there is a need to specify the concept of «activities that create increased danger to others» in Russian legislation. The subject of the article is the norms of law of Russian and foreign legislation regulating the institution of civil liability for harm caused to human life and health by activities that create an increased danger to others. The article is written using General scientific, philosophical and special legal methods of cognition. Based on the results, the article assesses the specifics of regulating harm caused by activities that create an increased danger to others in foreign legislation. Based on the research, it is proposed to distinguish the concepts of «source of increased danger» and «activities that are associated with increased danger to others» in Russian legislation, adding a note to article 1079 of the Civil code of the Russian Federation, as well as to specify the list of sources of increased danger, including unmanned vehicles and fighting dogs

Risks of clinical trial protocol amendments according to duration of the trial

Background. No clinical trial could be initiated and conducted without appropriate clinical trial protocol. Any change in information relating to patients’ safety and health during the trial must be recorded and approved by a form of amendment to the clinical trial protocol, which is a time-consuming and financially expensive process for the Sponsors of these studies.Goal. To analyze the probability of releasing of clinical trials protocols amendments and to determine the most "pregnable" period for their occurrence in the course of the trials.Materials and Methods. The results of clinical trial protocols analysis are presented, which were approved by Russian Health Authorities between three years from 2017 to 2019 inclusive. In total, 20 protocols and 39 amendments were analyzed. Results. In the first year of the study, 21 amendments were issued, representing slightly more than half (54%) of the total number of amendments. During the second year, 12 amendments were issued, (31%). For the third year of the trial, only 3 amendments (7%) were made and for the fourth — 4, which is 8% of the total.Conclusion. The largest number of protocol amendments came out at first two years of clinical trial. Thus, they are the most "dangerous" years in the life of a clinical study in connection with the examination of developed protocol in real life. These first two years show how carefully the protocol was designed, how it meets the requirements of regulatory authorities, criteria and recommendations of professional associations, how feasible and effective the various criteria and procedures are

Impact of COVID-19 on clinical trials protocol amendments

The COVID-19 pandemic situation had a great impact on all spheres of people’s lives. It also affected clinical trials as Sponsors, sites and investigators faced a number of problems, such as systematic IMP taking, adherence to protocol visits, efficacy evaluations, laboratory procedures, and analyse

Studying laser radiation effect on steel structure and properties

There was studied the effect of laser radiation on the structure and properties of annealed and tempered steel with different content of carbon. For surface hardening there was used a laser complex equipped with Nd: YAG pulse laser with power density up to 30 kW/сm2. As a result of the carried-out studies there were calculated characteristics of laser, steel microstructure and properties

Conditions and technologies of students ecological culture formation

© Authors. Technical progress is closely connected with the social and everyday comfort of society, with the level of the needs of modern society, but the disruption of production cycles, the low level of environmental management culture, the unintelligible consequences of its power over the surrounding world, destroy the harmony of the environment and human beings. The purpose of the paper is directed to improve the professional training of graduates of higher educational institutions, capable of solving production problems with minimizing environmental risks. The authors revealed pedagogical approaches to environmental education and substantiated the essence of the concept "ecological culture of students". Pedagogical conditions that contribute to the formation of ecological culture of university students are developed, introduced and experimental tested. The paper is intended for teachers, heads of educational organizations, researchers dealing with environmental security issues

Transient receptor potential Ankyrin 1: structure, function and ligands

The aim of this study is to search and generalize information about structural features and molecular determinants, mechanisms of activation, action and modulation of TRPA1 as a universal pain and inflammation sensor, as well as the nature of activators and antagonists of this target and their therapeutic potentia