A straightforward synthesis of indole and benzofuran derivatives

A new methodology for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl diynes, have been easily converted into new unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran. Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives

A Simple Synthesis of Thioamides

Transition metal catalyzed cross-coupling reactions of Grignard reagents with N,N-dimethylthiocarbamoyl chloride provide a very simple and convenient method for the synthesis of various thioamides