PDGFR-α expression in invasive breast carcinomas by immunohistochemistry (streptavidin-biotin-peroxidase)

<p><b>Copyright information:</b></p><p>Taken from "Overexpression of platelet-derived growth factor receptor α in breast cancer is associated with tumour progression"</p><p>Breast Cancer Research 2005;7(5):R788-R795.</p><p>Published online 1 Aug 2005</p><p>PMCID:PMC1242156.</p><p>Copyright © 2005 Carvalho et al.; licensee BioMed Central Ltd.</p> Platelet-derived growth factor receptor α (PDGFR-α) expression in pericytes and smooth muscle cells of a blood vessel: internal control (original magnification × 200); Absence of PDGFR-α expression in neoplastic cells (original magnification × 200); PDGFR-α diffuse cytoplasmic expression in neoplastic cells (original magnification × 200; inset × 400); Neoplastic cells showing strong and diffuse cytoplasmic PDGFR-α expression (original magnification × 400)

Epidermal growth factor receptor structural alterations in gastric cancer-0

<p><b>Copyright information:</b></p><p>Taken from "Epidermal growth factor receptor structural alterations in gastric cancer"</p><p>http://www.biomedcentral.com/1471-2407/8/10</p><p>BMC Cancer 2008;8():10-10.</p><p>Published online 16 Jan 2008</p><p>PMCID:PMC2244615.</p><p></p>ain of EGFR – missense mutation (2300 C>T) in exon 20, leading to the substitution of the Alanine 767 for a Valine. (B) Diffuse gastric carcinoma with EGFR increased copy number caused by chromosome 7 polysomy. (C) Neoplastic cells exhibiting gene amplification with the formation of clusters with numerous signals for EGFR

Epidermal growth factor receptor structural alterations in gastric cancer-1

<p><b>Copyright information:</b></p><p>Taken from "Epidermal growth factor receptor structural alterations in gastric cancer"</p><p>http://www.biomedcentral.com/1471-2407/8/10</p><p>BMC Cancer 2008;8():10-10.</p><p>Published online 16 Jan 2008</p><p>PMCID:PMC2244615.</p><p></p>ain of EGFR – missense mutation (2300 C>T) in exon 20, leading to the substitution of the Alanine 767 for a Valine. (B) Diffuse gastric carcinoma with EGFR increased copy number caused by chromosome 7 polysomy. (C) Neoplastic cells exhibiting gene amplification with the formation of clusters with numerous signals for EGFR

Schematic representation of P-cadherin positive and negative breast cancer histological types

<p><b>Copyright information:</b></p><p>Taken from "P-cadherin expression in breast cancer: a review"</p><p>http://breast-cancer-research.com/content/9/5/214</p><p>Breast cancer research : BCR 2007;9(5):214-214.</p><p>Published online 31 Oct 2007</p><p>PMCID:PMC2242663.</p><p></p> In normal breast, P-cadherin is only expressed by myoepithelial cells and not by luminal epithelial cells. In the low-grade arm of breast carcinomas, the majority of lesions are negative for P-cadherin expression, such as invasive lobular carcinomas (ILC), tubular carcinomas, and well differentiated ductal carcinoma (DCIS) and invasive ductal carcinomas (IDC). In the other arm, high-grade lesions are frequently positive for this cadherin, including the medullary carcinomas, a subset of poor-differentiated DCIS and IDC, and the metaplastic carcinomas, which represent a clear subtype of basal-like carcinomas