Biomaterials and scaffolds for tissue engineering

Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of tissue engineering (TE) aims to regenerate damaged tissues by combining cells from the body with highly porous scaffold biomaterials, which act as templates for tissue regeneration, to guide the growth of new tissue. This article describes the functional requirements, and types, of materials used in developing state of the art of scaffolds for tissue engineering applications. Furthermore, it describes the challenges and where future research and direction is required in this rapidly advancing field

The problem of authority and the proposal for an Indigenous advisory body

INTRODUCTION: Proposals for the establishment of an Indigenous advisory body within the Australian Constitution are genuinely innovative and exciting. Designing such a body is a challenge. Aboriginal and Torres Strait Islander Australians have long sought better political representation. Indigenous Australians constitute approximately 3 per cent of the population, therefore—even with proportionate reserved seats—such a micro-minority will struggle to assert itself in the Federal Parliament. For this and other reasons, the Cape York Institute rejected proposals for reserved seats in the Federal Parliament as unworkable. Noel Pearson expressed the dilemma well: There’s no way that we’re going to regularly have members to speak on our behalf in the parliament, and yet parliament is regularly making laws about us. So a provision which makes us part of the formal process of parliament, I think that has got to be part of the discussion. A constitutional Indigenous advisory body is one way of resolving that dilemma

Influence of shear stress in perfusion bioreactor cultures for the development of three-dimensional bone tissue constructs: a review.

Bone tissue engineering aims to generate clinically applicable bone graft substitutes in an effort to ease the demands and reduce the potential risks associated with traditional autograft and allograft bone replacement procedures. Biomechanical stimuli play an important role under physiologically relevant conditions in the normal formation, development, and homeostasis of bone tissue--predominantly, strain (predicted levels in vivo for humans \u3c2000\u3eμε) caused by physical deformation, and fluid shear stress (0.8-3 Pa), generated by interstitial fluid movement through lacunae caused by compression and tension under loading. Therefore, in vitro bone tissue cultivation strategies seek to incorporate biochemical stimuli in an effort to create more physiologically relevant constructs for grafting. This review is focused on collating information pertaining to the relationship between fluid shear stress, cellular deformation, and osteogenic differentiation, providing further insight into the optimal culture conditions for the creation of bone tissue substitutes

Hybrid Software Development Approaches in Practice: A European Perspective

Agile and traditional development approaches are used in combination in todays software development. To improve the understanding and to provide better guidance for selecting appropriate development approaches, it is important to analyze such combinations in practice. Results obtained from an online survey strongly confirm that hybrid development approaches are widely used in industry. Our results show that hybrid development approaches: (i) have become reality for nearly all companies; (ii) are applied to specific projects even in the presence of company-wide policies for process usage; (iii) are neither planned nor designed but emerge from the evolution of different work practices; and, (iv) are consistently used regardless of company size or industry secto

IV.3. Bioreactors in tissue engineering.

IV.3. Bioreactors in tissue engineering

Electromyographic analyses of the erector spinae muscles during golf swings using four different clubs

The purpose of this study was to compare the electromyography (EMG) patterns of the thoracic and lumbar regions of the erector spinae (ES) muscle during the golf swing whilst using four different golf clubs. Fifteen right-handed male golfers performed a total of twenty swings in random order using the driver, 4-iron, 7-iron and pitching-wedge. Surface EMG was recorded from the lead and trail sides of the thoracic and lumbar regions of the ES muscle (T8, L1 and L5 lateral to the spinous-process). Three-dimensional high-speed video analysis was used to identify the backswing, forward swing, acceleration, early and late follow-through phases of the golf swing. No significant differences in muscle-activation levels from the lead and trail sides of the thoracic and lumbar regions of the ES muscle were displayed between the driver, 4-iron, 7-iron and pitching-wedge (P > 0.05). The highest mean thoracic and lumbar ES muscle-activation levels were displayed in the forward swing (67–99% MVC) and acceleration (83–106% MVC) phases of the swing for all clubs tested. The findings from this study show that there were no significant statistical differences between the driver, 4-iron, 7-iron and pitching-wedge when examining muscle activity from the thoracic and lumbar regions of the ES muscle

Comparison of thoracic and lumbar erector spinae muscle activation before and after a golf practice session

Lower back pain is commonly associated with golfers. The study aimed: to determine whether thoracic- and lumbar-erector-spinae muscle display signs of muscular fatigue after completing a golf practice session, and to examine the effect of the completed practice session on club head speed, ball speed and absolute carry distance performance variables. Fourteen right-handed male golfers participated in the laboratory-based-study. Surface electromyography (EMG) data was collected from the lead and trail sides of the thoracic- and lumbar-erector-spinae muscle. Normalized root mean squared (RMS) EMG activation levels and performance variables for the golf swings were compared before and after the session. Fatigue was assessed using median frequency (MDF) and RMS during the maximum voluntary contraction (MVC) performed before and after the session. No significant differences were observed in RMS thoracic- and lumbar-erector-spinae muscle activation levels during the five phases of the golf swing and performance variables before and after the session (p > .05). Significant changes were displayed in MDF and RMS in the lead lower lumbar and all trail regions of the erector-spinae muscle when comparing the MVC performed before and after the session (p < .05). Fatigue was evident in the trail side of the erector-spinae muscle after the session

Spitzer Planet Limits around the Pulsating White Dwarf GD66

We present infrared observations in search of a planet around the white dwarf, GD66. Time-series photometry of GD66 shows a variation in the arrival time of stellar pulsations consistent with the presence of a planet with mass > 2.4Mj. Any such planet is too close to the star to be resolved, but the planet's light can be directly detected as an excess flux at 4.5um. We observed GD66 with the two shorter wavelength channels of IRAC on Spitzer but did not find strong evidence of a companion, placing an upper limit of 5--7Mj on the mass of the companion, assuming an age of 1.2--1.7Gyr.Comment: 10 pages, accepted by Ap