A method for localizing wing flow separation at stall to alleviate spin entry tendencies

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76908/1/AIAA-1978-1476-516.pd

Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety.

Artemisia dracunculus L. (tarragon) has a long history of use as a spice and remedy. Two well-described "cultivars" (Russian and French) are used widely and differ in ploidy level, morphology, and chemistry. Key biologically active secondary metabolites are essential oils (0.15-3.1%), coumarins (>1%), flavonoids, and phenolcarbonic acids. In vivo studies mainly in rodents, particularly from Russian sources, highlight potential anti-inflammatory, hepatoprotective, and antihyperglycemic effects. Despite concerns about the toxic effects of two of its main constituents, estragole (up to 82%) and methyleugenol (up to 39%), no acute toxicity or mutagenic activity has been reported at doses relevant for human consumption. Water extracts of A. dracunculus contain very low amounts of estragole and methyleugenol and, therefore, are considered to pose a very limited risk. Overall, a stronger focus on clinical studies and precise taxonomic and phytochemical definition of the source material will be essential for future research efforts

Alleviation of Spin-Entry Tendencies through Localization of Wing-Flow Separation

Studies have been made on several wing leading-edge modifications applicable at present to single-engine light aircraft, which produce stabilizing vortices at stall and beyond. These vortices have the effect of fixing the stall pattern of the wing such that the various portions of the wing upper surface stall nearly symmetrically. The lift coefficient produced is maintained at a high level to angles of attack significantly above the stall angle of the unmodified wing, and the divergence in roll usually is reduced to a controllable level. It is hypothesized that these characteristics will help prevent inadvertent spin entry after a stall. Results are presented from recent large-scale wind-tunnel tests of a typical light aircraft, both with and without the modifications. The data indicate (hot the static stall and poststall characteristics of this aircraft, in a typical landing-approach condition, are noticeably improved when it suitable leading-edge modification is employed; and also that no appreciable aerodynamic penalties are evident in the normal flight envelope

Analytical Investigation of Innovation Dynamics Considering Stochasticity in the Evaluation of Fitness

We investigate a selection-mutation model for the dynamics of technological innovation,a special case of reaction-diffusion equations. Although mutations are assumed to increase the variety of technologies, not their average success ("fitness"), they are an essential prerequisite for innovation. Together with a selection of above-average technologies due to imitation behavior, they are the "driving force" for the continuous increase in fitness. We will give analytical solutions for the probability distribution of technologies for special cases and in the limit of large times. The selection dynamics is modelled by a "proportional imitation" of better technologies. However, the assessment of a technology's fitness may be imperfect and, therefore, vary stochastically. We will derive conditions, under which wrong assessment of fitness can accelerate the innovation dynamics, as it has been found in some surprising numerical investigations.Comment: For related work see http://www.helbing.or

Optimal Self-Organization

We present computational and analytical results indicating that systems of driven entities with repulsive interactions tend to reach an optimal state associated with minimal interaction and minimal dissipation. Using concepts from non-equilibrium thermodynamics and game theoretical ideas, we generalize this finding to an even wider class of self-organizing systems which have the ability to reach a state of maximal overall ``success''. This principle is expected to be relevant for driven systems in physics like sheared granular media, but it is also applicable to biological, social, and economic systems, for which only a limited number of quantitative principles are available yet.Comment: This is the detailled revised version of a preprint on ``Self-Organised Optimality'' (cond-mat/9903319). For related work see http://www.theo2.physik.uni-stuttgart.de/helbing.html and http://angel.elte.hu/~vicsek

Modeling Supply Networks and Business Cycles as Unstable Transport Phenomena

Physical concepts developed to describe instabilities in traffic flows can be generalized in a way that allows one to understand the well-known instability of supply chains (the so-called ``bullwhip effect''). That is, small variations in the consumption rate can cause large variations in the production rate of companies generating the requested product. Interestingly, the resulting oscillations have characteristic frequencies which are considerably lower than the variations in the consumption rate. This suggests that instabilities of supply chains may be the reason for the existence of business cycles. At the same time, we establish some link to queuing theory and between micro- and macroeconomics.Comment: For related work see http://www.helbing.or

Statistical Mechanics of Canonical-Dissipative Systems and Applications to Swarm Dynamics

We develop the theory of canonical-dissipative systems, based on the assumption that both the conservative and the dissipative elements of the dynamics are determined by invariants of motion. In this case, known solutions for conservative systems can be used for an extension of the dynamics, which also includes elements such as the take-up/dissipation of energy. This way, a rather complex dynamics can be mapped to an analytically tractable model, while still covering important features of non-equilibrium systems. In our paper, this approach is used to derive a rather general swarm model that considers (a) the energetic conditions of swarming, i.e. for active motion, (b) interactions between the particles based on global couplings. We derive analytical expressions for the non-equilibrium velocity distribution and the mean squared displacement of the swarm. Further, we investigate the influence of different global couplings on the overall behavior of the swarm by means of particle-based computer simulations and compare them with the analytical estimations.Comment: 14 pages incl. 13 figures. v2: misprints in Eq. (40) corrected, ref. updated. For related work see also: http://summa.physik.hu-berlin.de/~frank/active.htm

Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains

Candida albicans has been previously shown to stimulate the production of Pseudomonas aeruginosa phenazine toxins in dual-species colony biofilms. Here, we report that P. aeruginosa lasR mutants, which lack the master quorum sensing system regulator, regain the ability to produce quorum-sensing-regulated phenazines when cultured with C. albicans. Farnesol, a signalling molecule produced by C. albicans, was sufficient to stimulate phenazine production in LasR− laboratory strains and clinical isolates. P. aeruginosa ΔlasR mutants are defective in production of the Pseudomonas quinolone signal (PQS) due to their inability to properly induce pqsH, which encodes the enzyme necessary for the last step in PQS biosynthesis. We show that expression of pqsH in a ΔlasR strain was sufficient to restore PQS production, and that farnesol restored pqsH expression in ΔlasR mutants. The farnesol-mediated increase in pqsH required RhlR, a transcriptional regulator downstream of LasR, and farnesol led to higher levels of N-butyryl-homoserine lactone, the small molecule activator of RhlR. Farnesol promotes the production of reactive oxygen species (ROS) in a variety of species. Because the antioxidant N-acetylcysteine suppressed farnesol-induced RhlR activity in LasR− strains, and hydrogen peroxide was sufficient to restore PQS production in las mutants, we propose that ROS are responsible for the activation of downstream portions of this quorum sensing pathway. LasR mutants frequently arise in the lungs of patients chronically infected with P. aeruginosa. The finding that C. albicans, farnesol or ROS stimulate virulence factor production in lasR strains provides new insight into the virulence potential of these strains

Could Seals Prevent Cod Recovery in the Baltic Sea?

Fish populations are increasingly affected by multiple human and natural impacts including exploitation, eutrophication, habitat alteration and climate change. As a result many collapsed populations may have to recover in ecosystems whose structure and functioning differ from those in which they were formerly productive and supported sustainable fisheries. Here we investigate how a cod (Gadus morhua) population in the Baltic Sea whose biomass was reduced due to a combination of high exploitation and deteriorating environmental conditions might recover and develop in the 21st century in an ecosystem that likely will change due to both the already started recovery of a cod predator, the grey seal Halichoerus grypus, and projected climate impacts. Simulation modelling, assuming increased seal predation, fishing levels consistent with management plan targets and stable salinity, shows that the cod population could reach high levels well above the long-term average. Scenarios with similar seal and fishing levels but with 15% lower salinity suggest that the Baltic will still be able to support a cod population which can sustain a fishery, but biomass and yields will be lower. At present knowledge of cod and seal interactions, seal predation was found to have much lower impact on cod recovery, compared to the effects of exploitation and salinity. These results suggest that dual management objectives (recovery of both seal and cod populations) are realistic but success in achieving these goals will also depend on how climate change affects cod recruitment