11 research outputs found
Glossario dei termini di farmacognosia impiegati nella Farmacopea ufficiale italiana
The terms contanined in the Glossary are translated also into English and FrenchConsiglio Nazionale delle Ricerche (CNR). Biblioteca Centrale / CNR - Consiglio Nazionale delle RichercheSIGLEITItal
GC/MS analysis of the volatile constituents of Artemisia annua L. at different development stages
Chemical composition of the essential oil and volatile constituents from aromatic waters of Balsamita suaveolens Pers
Composition of the essential oil of fennel teas obtained by classical infusion or microwave decoction of unbroken and crushed fruits and by some pre-packaged teabags and instant teas
New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications
The clinically established gold-based antiarthritic drug auranofin (AF) manifests a pronounced reactivity toward thiol and selenol groups of proteins. In particular, AF behaves as a potent inhibitor of mammalian thioredoxin reductases causing severe intracellular oxidative stress. Given the high sensitivity of Plasmodium falciparum to oxidative stress, we thought that auranofin might act as an effective antimalarial agent. Thus, we report here new experimental results showing that auranofin and a few related gold complexes strongly inhibit P. falciparum growth in vitro. The observed antiplasmodial effects probably arise from direct inhibition of P. falciparum thioredoxin reductase. The above findings and the safe toxicity profile of auranofin warrant rapid evaluation of AF for malaria treatment in animal models