Chemical abundances and properties of the ionized gas in NGC 1705

We obtained [O III] narrow-band imaging and multi-slit MXU spectroscopy of the blue compact dwarf (BCD) galaxy NGC 1705 with FORS2@VLT to derive chemical abundances of PNe and H II regions and, more in general, to characterize the properties of the ionized gas. The auroral [O III]\lambda4363 line was detected in all but one of the eleven analyzed regions, allowing for a direct estimate of their electron temperature. The only object for which the [O III]\lambda4363 line was not detected is a possible low-ionization PN, the only one detected in our data. For all the other regions, we derived the abundances of Nitrogen, Oxygen, Neon, Sulfur and Argon out to ~ 1 kpc from the galaxy center. We detect for the first time in NGC 1705 a negative radial gradient in the oxygen metallicity of -0.24 \pm 0.08 dex kpc^{-1}. The element abundances are all consistent with values reported in the literature for other samples of dwarf irregular and blue compact dwarf galaxies. However, the average (central) oxygen abundance, 12 + log(O/H)=7.96 \pm 0.04, is ~0.26 dex lower than previous literature estimates for NGC 1705 based on the [O III]\lambda4363 line. From classical emission-line diagnostic diagrams, we exclude a major contribution from shock excitation. On the other hand, the radial behavior of the emission line ratios is consistent with the progressive dilution of radiation with increasing distance from the center of NGC 1705. This suggests that the strongest starburst located within the central $\sim$150 pc is responsible for the ionization of the gas out to at least $\sim$1 kpc. The gradual dilution of the radiation with increasing distance from the center reflects the gradual and continuous transition from the highly ionized H II regions in the proximity of the major starburst into the diffuse ionized gas.Comment: Accepted for publication on A

Epstein-Barr virus and multiple sclerosis.

PURPOSE OF REVIEW: Recent studies have revived interest in the long-scrutinized association between Epstein-Barr virus (EBV) and multiple sclerosis (MS). We review this evidence and discuss it in relation to MS pathological and clinical features and patients' response to immunosuppressive therapies. RECENT FINDINGS: Serological evidence of previous exposure to EBV in children with MS supports a role for EBV infection early in MS pathogenesis, as already indicated by prospective studies in adults. Higher antibody titers and T-cell responses to EBV in patients compared to healthy EBV carriers indicate possible continuous viral reactivation, whereas there is some evidence that EBV could break immune tolerance to myelin antigens through molecular mimicry. Detection of EBV-infected B-cells in patients' brain raises the possibility that intrathecal B-cell abnormalities and T-cell-mediated immunopathology in MS are the consequence of a persistently dysregulated EBV infection. Accordingly, targeting T-cells and/or B-cells with monoclonal antibody therapies ameliorates MS. Whether EBV has a causative or pathogenic role in MS can now be addressed in relation to genetic, hormonal and other environmental influences that may affect EBV-host interactions. SUMMARY: By shedding light on the involvement of EBV in MS, these findings will pave the way to disease prevention and increase the therapeutic index of future treatments

Multi-Epoch HST Observations of IZw18: Characterization of Variable Stars at Ultra-Low Metallicities

Variable stars have been identified for the first time in the very metal-poor Blue Compact dwarf galaxy IZw18, using deep multi-band (F606W, F814W)time-series photometry obtained with the Advanced Camera for Surveys (ACS) on board the Hubble Space Telescope (HST). We detected 34 candidate variable stars in the galaxy. We classify three of them as Classical Cepheids, with periods of 8.71, 125.0 and 130.3 days, respectively, and other two as long period variables with periodicities longer than a hundred days. These are the lowest metallicity Classical Cepheids known so far, thus providing the opportunity to explore and fit models of stellar pulsation fo Classical Cepheids at previously inaccessible metallicities. The period distribution of the confirmed Cepheids is markedly different from what is seen in other nearby galaxies, which is likely related to the star bursting nature of IZw18. By applying to the 8.71 days Cepheid theoretical Wesenheit (V,I) relations based on new pulsation models of Classical Cepheids specifically computed for the extremely low metallicity of this galaxy (Z=0.0004, Y=0.24), we estimate the distance modulus of IZw18 to be mu_0= 31.4pm0.2 D=19.0^{+1.8}_{-1.7}Mpc) for canonical models of Classical Cepheids, and of 31.2pm0.2 mag (D=17.4^{+1.6}_{-1.6}Mpc) using over luminous models. The theoretical modeling of the star's light curves provides mu_0=31.4pm0.1 mag, D=19.0^{+0.9}_{-0.9} Mpc, in good agreement with the results from the theoretical Wesenheit relations. These pulsation distances bracket the distance of 18.2pm1.5Mpc inferred by Aloisi et al. (2007) using the galaxy's Red Giant Branch Tip.Comment: 13 Pages, 6 Figures, accepted, Ap

The Star Formation History of NGC 1705: a Post-Starburst Galaxy on the Verge of Activity

We infer the star formation history in different regions of the blue compact dwarf NGC 1705 by comparing synthetic color-magnitude diagrams with HST optical and near-infrared photometry. We find that NGC 1705 is not a young galaxy because its star formation commenced at least 5 Gyr ago. On the other hand, we confirm the existence of a recent burst of star formation between 15 and 10 Myr ago. We also find evidence for new strong activity, which started 3 Myr ago and is still continuing. The old population is spread across the entire galaxy, while the young and intermediate stars are more concentrated in the central regions. We derive an almost continuous star formation with variable rate, and exclude the presence of long quiescent phases between the episodes during the last ~1 Gyr. The central regions experienced an episode of star formation of \~0.07 Msun/yr (for a Salpeter initial mass function [IMF]) 15 to 10 Myr ago. This coincides with the strong activity in the central super star cluster. We find a rate of ~0.3 Msun/yr for the youngest ongoing burst which started ~3 Myr ago. This is higher than in other dwarfs and comparable to the rate of NGC 1569. The star formation rate of earlier episodes is not especially high and falls in the range 10^{-3}-10^{-1} Msun/yr. The IMF is close to the Salpeter value or slightly steeper.Comment: 34 pages, including 6 tables and 14 .ps figures (9 in colour), AJ in pres

PNe and H II regions in the starburst irregular galaxy NGC 4449 from LBT MODS data

We present deep 3500$-$10000 $\AA$ spectra of H II regions and planetary nebulae (PNe) in the starburst irregular galaxy NGC 4449, acquired with the Multi Object Double Spectrograph at the Large Binocular Telescope. Using the "direct" method, we derived the abundance of He, N, O, Ne, Ar, and S in six H II regions and in four PNe in NGC 4449. This is the first case of PNe studied in a starburst irregular outside the Local Group. Our H II region and PN sample extends over a galacto-centric distance range of $\approx$2 kpc and spans $\approx$0.2 dex in oxygen abundance, with average values of $12+\log(O/H)=8.37 \pm 0.05$ and $8.3 \pm 0.1$ for H II regions and PNe, respectively. PNe and H II regions exhibit similar oxygen abundances in the galacto-centric distance range of overlap, while PNe appear more than $\sim$1 dex enhanced in nitrogen with respect to H II regions. The latter result is the natural consequence of N being mostly synthesized in intermediate-mass stars and brought to the stellar surface during dredge-up episodes. On the other hand, the similarity in O abundance between H II regions and PNe suggests that NGC 4449' s interstellar medium has been poorly enriched in $\alpha$ elements since the progenitors of the PNe were formed. Finally, our data reveal the presence of a negative oxygen gradient for both H II regions and PNe, whilst nitrogen does not exhibit any significant radial trend. We ascribe the (unexpected) nitrogen behaviour as due to local N enrichment by the conspicuous Wolf-Rayet population in NGC 4449.Comment: Accepted for publication on Ap

Chemical abundances and radial velocities in the extremely metal-poor galaxy DDO 68

We present chemical abundances and radial velocities of six HII regions in the extremely metal-poor star-forming dwarf galaxy DDO 68. They are derived from deep spectra in the wavelength range 3500 - 10,000 {\AA}, acquired with the Multi Object Double Spectrograph (MODS) at the Large Binocular Telescope (LBT). In the three regions where the [O III]$\lambda$4363 {\AA} line was detected, we inferred the abundance of He, N, O, Ne, Ar, and S through the "direct" method. We also derived the oxygen abundances of all the six regions adopting indirect method calibrations. We confirm that DDO 68 is an extremely metal-poor galaxy, and a strong outlier in the luminosity - metallicity relation defined by star-forming galaxies. With the direct-method we find indeed an oxygen abundance of 12+log(O/H)=7.14$\pm$0.07 in the northernmost region of the galaxy and, although with large uncertainties, an even lower 12+log(O/H)=6.96$\pm$0.09 in the "tail". This is, at face value, the most metal-poor direct abundance detection of any galaxy known. We derive a radial oxygen gradient of -0.06$\pm$0.03 dex/kpc (or -0.30 dex $R_{25}^{-1}$) with the direct method, and a steeper gradient of -0.12$\pm$0.03 dex/kpc (or -0.59 dex $R_{25}^{-1}$) from the indirect method. For the $\alpha$-element to oxygen ratios we obtain values in agreement with those found in other metal-poor star-forming dwarfs. For nitrogen, instead, we infer much higher values, leading to log(N/O)$\sim-1.4$, at variance with the suggested existence of a tight plateau at $-1.6$ in extremely metal poor dwarfs. The derived helium mass fraction ranges from Y=0.240$\pm$0.005 to Y=0.25$\pm$0.02, compatible with standard big bang nucleosynthesis. Finally, we measured HII region radial velocities in the range 479$-$522 km/s from the tail to the head of the "comet", consistent with the rotation derived in the HI.Comment: Accepted for publication in MNRA