FACTORS FOR ACTIVE LONGEVITY OF OLD PEOPLE ATTENDING DAY CARE CENTRE IN VELIKO TARNOVO

One of the major global problems facing humanity in the 21st century is population ageing. The proportion of the elderly /60-74 years/, old people /75-89 years/ and the long-lived /over 90 years/ is increasing [4].This makes the problems related to the elderly population in Bulgaria particularly relevant, as they are fully adequate to the demographic development and naturally increase the interest in the needs of the elderly, approaches and ways to promote their active and healthy lifestyle. From this perspective, knowledge of the factors contributing to active ageing would help to provide effective psychological support and improve the quality of life of the old person. Objective of the study: to identify the factors of active longevity in the elderly attending the Day-care centre in Veliko Tarnovo. Materials and Methods: Object of the study: factors for active longevity in the elderly attending a Day-care centre in Veliko Tarnovo. Subject of the study: the process of identification of the factors of active longevity in the elderly attending a Day-care centre in Veliko Tarnovo Methods used: survey method, statistical processing and graphical interpretation of the results. Results and Discussion: based on the conducted study, the problem of the need to inform the elderly about the diversity of factors for active longevity and the implementation of various programs for their management through active physical activity clearly emerges.Conclusion: The need for systematic physical activity to be realized on the basis of a complex of physical exercises, built on a scientifically based methodology, is proved

3′UTR-located ALU Elements: Donors of Potetial miRNA Target Sites and Mediators of Network miRNA-based Regulatory Interactions

Recent research data reveal complex, network-based interactions between mobile elements and regulatory systems of eukaryotic cells. In this article, we focus on regulatory interactions between Alu elements and micro RNAs (miRNAs). Our results show that the majority of the Alu sequences inserted in 3′UTRs of analyzed human genes carry strong potential target sites for at least 53 different miRNAs. Thus, 3′UTR-located Alu elements may play the role of mobile regulatory modules that supply binding sites for miRNA regulation. Their abundance and ability to distribute a set of certain miRNA target sites may have an important role in establishment, extension, network organization, and, as we suppose – in the regulation and environment-dependent activation/inactivation of some elements of the miRNA regulatory system, as well as for a larger scale RNA-based regulatory interactions. The Alu-miRNA connection may be crucial especially for the primate/human evolution

Chloroplast genome assembly approaches from NGS data

The advent of Next Generation Sequencing platforms led to increase of research in whole genome assembly algorithms and software. Illumina Genome Analyzer produces a large amount of sequencing data, with a shorted read length, higher coverage and different errors in comparison to Sanger Sequencing. In response to this, several new assemblers were developed specifically for de novo assembly of next generation sequencing. This study compares software assembly packages named Edena, SPAdes, ABySS and analyzes results delivered by de novo assembly experiments. We show that assembly job of small genome can be completed in a short time on a 32 bit Linux OS with 4 GB RAM, indicating than de novo assembly can be executed and millions of very reads assembled on a desktop computer

3'UTR-located Elements: Donors of Potetial miRNA Target Sites and Mediators of Network miRNA-based Regulatory Interactions

Recent research data reveal complex, network-based interactions between mobile elements and regulatory systems of eukaryotic cells. In this article, we focus on regulatory interactions between Alu elements and micro RNAs (miRNAs). Our results show that the majority of the Alu sequences inserted in 3'UTRs of analyzed human genes carry strong potential target sites for at least 53 different miRNAs. Thus, 3'UTR-located Alu elements may play the role of mobile regulatory modules that supply binding sites for miRNA regulation. Their abundance and ability to distribute a set of certain miRNA target sites may have an important role in establishment, extension, network organization, and, as we suppose – in the regulation and environment-dependent activation/inactivation of some elements of the miRNA regulatory system, as well as for a larger scale RNA-based regulatory interactions. The Alu -miRNA connection may be crucial especially for the primate/human evolution

A strategy for conservation and investigation of the protected resurrection plant Haberlea rhodopensis Friv.

Representatives of the resurrection plants from Gesneriaceae family are included in the Red Book of Bulgaria, in the European Register of rare, endangered, and endemic plants, and are subjects of world’s conventions on the preservation of the biodiversity. The unique feature of these plants to recover from prolonged dehydration (anabiosis) is explored in numerous studies. These species are also Tertiary relics, so they could give us important knowledge about plant evolution.Our research group at the University of Plovdiv has established a national in vitro gene bank for Haberlea rhodopensis Friv. (25 localities) and Ramonda serbica Panc. (2 localities) from Bulgaria. The national gene bank is based on original and modified in vitro technologies and can serve as a conservation and biodiversity investigation center for the family Gesneriaceae.Basing on our work with Haberlea rhodopensis Friv., we are developing a strategy for conservation and investigation of rare and relic plant species (mapping and exploration of habitats – assessing the local risk of extinction - introducing in an in vitro gene bank - model plants for research – adaptation and possible re-introduction in endangered habitats). This strategy can be adapted and used for conservation and investigation of other rare, protected, relic and endemic plants from other regions of Europe and worldwide

A strategy for conservation and investigation of the protected resurrection plant Haberlea rhodopensis Friv.

Volume: 6Start Page: 41End Page: 6