6,789 research outputs found
Disclosure of researcher allegiance in meta-analyses and randomised controlled trials of psychotherapy: a systematic appraisal
Psychotherapy research may suffer from factors such as a researchers own therapy allegiance. The aim of this study was to evaluate if researcher allegiance (RA) was reported in meta-analyses and randomised controlled trials (RCTs) of psychotherapeutic treatments.Systematic approach using meta-analyses of different types of psychotherapies.Medline, PsycINFO and Cochrane Database of Systematic Reviews.We evaluated meta-analyses of RCTs regarding various types of psychotherapies. Meta-analyses were eligible if they included at least one RCT with RA and they were published in journals in Medline, PsycINFO and Cochrane Database of Systematic Reviews with an impact factor larger than 5.We identified 146 eligible meta-analyses that synthesised data from a total of 1198 unique RCTs. Only 25 of the meta-analyses (17.2%) reported allegiance and only 6 (4.1%) used a proper method to control its effect. Of the 1198 eligible primary RCTs, 793 (66.3%) were allegiant. Authors in 25 of these 793 RCTs (3.2%) reported their allegiance while only one study (0.2%) controlled for its effect.The vast majority among a group of published meta-analyses and RCTs of psychotherapeutic treatments seldom reported and evaluated the allegiance effect. The results of the present study highlight a major lack of this information in meta-analyses and their included studies, though meta-analyses perform slightly better than RCTs. Stringent guidelines should be adopted by journals in order to improve reporting and attenuate possible effects of RA in future research
Dielectric relaxation and Charge trapping characteristics study in Germanium based MOS devices with HfO2 /Dy2O3 gate stacks
In the present work we investigate the dielectric relaxation effects and
charge trapping characteristics of HfO2 /Dy2O3 gate stacks grown on Ge
substrates. The MOS devices have been subjected to constant voltage stress
(CVS) conditions at accumulation and show relaxation effects in the whole range
of applied stress voltages. Applied voltage polarities as well as thickness
dependence of the relaxation effects have been investigated. Charge trapping is
negligible at low stress fields while at higher fields (>4MV/cm) it becomes
significant. In addition, we give experimental evidence that in tandem with the
dielectric relaxation effect another mechanism- the so-called Maxwell-Wagner
instability- is present and affects the transient current during the
application of a CVS pulse. This instability is also found to be field
dependent thus resulting in a trapped charge which is negative at low stress
fields but changes to positive at higher fields.Comment: 27pages, 10 figures, 3 tables, regular journal contribution (accepted
in IEEE TED, Vol.50, issue 10
Superconductivity-Induced Anderson Localisation
We have studied the effect of a random superconducting order parameter on the
localization of quasi-particles, by numerical finite size scaling of the
Bogoliubov-de Gennes tight-binding Hamiltonian. Anderson localization is
obtained in d=2 and a mobility edge where the states localize is observed in
d=3. The critical behavior and localization exponent are universal within error
bars both for real and complex random order parameter. Experimentally these
results imply a suppression of the electronic contribution to thermal transport
from states above the bulk energy gap.Comment: 4 pages, revtex file, 3 postscript figure
Environment-Mediated Quantum State Transfer
We propose a scheme for quantum state transfer(QST) between two qubits which
is based on their individual interaction with a common boson environment. The
corresponding single mode spin-boson Hamiltonian is solved by mapping it onto a
wave propagation problem in a semi-infinite ladder and the fidelity is
obtained. High fidelity occurs when the qubits are equally coupled to the boson
while the fidelity becomes smaller for nonsymmetric couplings. The complete
phase diagram for such an arbitrary QST mediated by bosons is discussed.Comment: 6 pages and 5 figure
Gate Stack Dielectric Degradation of Rare-Earth Oxides Grown on High Mobility Ge Substrates
We report on the dielectric degradation of Rare-Earth Oxides (REOs), when
used as interfacial buffer layers together with HfO2 high-k films (REOs/HfO2)
on high mobility Ge substrates. Metal-Oxide-Semiconductor (MOS) devices with
these stacks,show dissimilar charge trapping phenomena under varying levels of
Constant- Voltage-Stress (CVS) conditions, which also influences the measured
densities of the interface (Nit) and border (NBT) traps. In the present study
we also report on C-Vg hysteresis curves related to Nit and NBT. We also
propose a new model based on Maxwell-Wagner instabilities mechanism that
explains the dielectric degradations (current decay transient behavior) of the
gate stack devices grown on high mobility substrates under CVS bias from low to
higher fields, and which is unlike to those used for other MOS devices.
Finally, the time dependent degradation of the corresponding devices revealed
an initial current decay due to relaxation, followed by charge trapping and
generation of stress-induced leakage which eventually lead to hard breakdown
after long CVS stressing.Comment: 19pages (double space), 7 figures, original research article,
Submitted to JAP (AIP
Scaling of Level Statistics at the Disorder-Induced Metal-Insulator Transition
The distribution of energy level separations for lattices of sizes up to
282828 sites is numerically calculated for the Anderson model.
The results show one-parameter scaling. The size-independent universality of
the critical level spacing distribution allows to detect with high precision
the critical disorder . The scaling properties yield the critical
exponent, , and the disorder dependence of the correlation
length.Comment: 11 pages (RevTex), 3 figures included (tar-compressed and uuencoded
using UUFILES), to appear in Phys.Rev. B 51 (Rapid Commun.
A Body Shape Index (ABSI), hip index and risk of cancer in the UK Biobank cohort
Abdominal size is associated positively with the risk of some cancers but the influence of body mass index (BMI) and gluteofemoral size is unclear because waist and hip circumference are strongly correlated with BMI. We examined associations of 33 cancers with A Body Shape Index (ABSI) and hip index (HI), which are independent of BMI by design, and compared these with waist and hip circumference, using multivariable Cox proportional hazards models in UK Biobank. During a mean follow up of seven years, 14,682 incident cancers were ascertained in 200,289 men and 12,965 cancers in 230,326 women. In men, ABSI was associated positively with cancers of the head and neck (hazard ratio HR=1.14; 95% confidence interval 1.03-1.26 per one standard deviation increment), oesophagus (adenocarcinoma, HR=1.27; 1.12-1.44), gastric cardia (HR=1.31; 1.07-1.61), colon (HR=1.18; 1.10-1.26), rectum (HR=1.13; 1.04-1.22), lung (adenocarcinoma, HR=1.16; 1.03-1.30; squamous-cell carcinoma (SCC), HR=1.33; 1.17-1.52), and bladder (HR=1.15; 1.04-1.27), while HI was associated inversely with cancers of the oesophagus (adenocarcinoma, HR=0.89; 0.79-1.00), gastric cardia (HR=0.79; 0.65-0.96), colon (HR=0.92; 0.86-0.98), liver (HR=0.86; 0.75-0.98), and multiple myeloma (HR=0.86; 0.75-1.00). In women, ABSI was associated positively with cancers of the head and neck (HR=1.27; 1.10-1.48), oesophagus (SCC, HR=1.37; 1.07-1.76), colon (HR=1.08; 1.01-1.16), lung (adenocarcinoma, HR=1.17; 1.06-1.29; SCC, HR=1.40; 1.20-1.63; small-cell, HR=1.39; 1.14-1.69), kidney (clear-cell, HR=1.25; 1.03-1.50), and post-menopausal endometrium (HR=1.11; 1.02-1.20), while HI was associated inversely with skin SCC (HR=0.91; 0.83-0.99), post-menopausal kidney cancer (HR=0.77; 0.67-0.88) and post-menopausal melanoma (HR=0.90; 0.83-0.98). Unusually, ABSI was associated inversely with melanoma in men (HR=0.89; 0.82-0.96) and pre-menopausal women (HR=0.77; 0.65-0.91). Waist and hip circumference reflected associations with BMI, when examined individually, and provided biased risk estimates, when combined with BMI. In conclusion, preferential positive associations of ABSI or inverse of HI with several major cancers indicate an important role of factors determining body shape in cancer development
Associations of body shape index (ABSI) and hip index with liver, metabolic, and inflammatory biomarkers in the UK Biobank cohort
Associations of liver, metabolic, and inflammatory biomarkers in blood with body shape are unclear, because waist circumference (WC) and hip circumference (HC) are dependent on overall body size, resulting in bias. We have used the allometric “a body shape index” (ABSI = WC(mm)∗Weight(kg)-2/3∗Height(m)5/6) and hip index (HIwomen = HC(cm)∗Weight(kg)-0.482∗Height(cm)0.310, HImen = HC(cm)∗Weight(kg)-2/5∗Height(cm)1/5), which are independent of body mass index (BMI) by design, in multivariable linear regression models for 121,879 UK Biobank men and 135,559 women. Glucose, glycated haemoglobin (HbA1c), triglycerides, low-density-lipoprotein cholesterol, apolipoprotein-B, alanine aminotransferase (ALT), gamma-glutamyltransferase, and lymphocytes were associated positively with BMI and ABSI but inversely with HI. High-density-lipoprotein cholesterol and apolipoprotein-A1 were associated inversely with BMI and ABSI but positively with HI. Lipid-related biomarkers and ALT were associated only with HI in obese men. C-reactive protein, neutrophils, monocytes, and alkaline phosphatase were associated positively, while bilirubin was associated inversely, with BMI and ABSI but not with HI. Associations were consistent within the clinical reference ranges but were lost or changed direction for low or high biomarker levels. Our study confirms associations with waist and hip size, independent of BMI, for metabolic biomarkers but only with waist size for inflammatory biomarkers, suggesting different contribution of the mechanistic pathways related to body shape
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