Aqueous Extract of Rauwolfia Vomitoria Afzel (Apocynaceae) Roots Effect on Blood Glucose Level of Normoglycemic and Hyperglycemic Rats

At 500, 700 and 1000 mg/ kg B.W., EARv causes, like glibenclamide at 10 mg/kg B.W., a reduction of blood glucose level of treated normoglycemic rats. In addition, EARv at 1000 mg/kg B.W. reducedand quickly nullifies the glucose tolerance in rats that is induced by oral administration of glucose (4 g/kg B.W.). This effect is also observed with glibenclamide (10 mg/kg B.W.). The phytochemical screening shows that EARv contains alkaloids, flavonoids, and antrhones and anthraquinones, catechin tannins, saponins and monoterpenoids. This study shows that the aqueous extract of Rauwolfia vomitoria has hypoglycemic and some antihyperglycemic properties, that justify its use in the treatment of diabetic hyperglycemia in traditional medicine.This study aims to assess the pharmacological effects of an aqueous extract roots of Rauwolfia vomitoria (EARv), a plant used in traditional medicine in the Ivory Coast to treat diabetes, on blood glucose normoglycemic rats and on glucose tolerance in rats by administration of glucose. The acute toxicity, as well as the phytochemicals present in this extract are also determined. During the experience, fives groups of rats received respectively distilled water, EARv at doses of 500, 700 and 1000 mg/kg of body weight and 10 mg/kg of glibenclamide. Then the blood glucose level of each rat was measured using a glucometer. Hyperglycemia was induced in rats by oral administration of glucose at dose of 4 g/kg. The rats were pretreated or post-treated of the same doses of tests substances and blood glucose level of each rat was measured. Acute toxicity by oral administration was studied in mice and phytochemical screening was performed by thin layer chromatography. The results show that EARv administered orally at doses up to 5000 mg/kg B.W., does not cause the death of the treated mice.

EFFETS HYPOGLYCEMIQUE ET ANTI-HYPERGLYCEMIQUE DE L’EXTRAIT ETHANOLIQUE 70 % DE RACINES DE RAUVOLFIA VOMITORIA AFZEL (APOCYNACEAE)

Rauwolfia vomitoria Afzel. (Apocynaceae) is a plant used in traditional medicine in the Ivory Coast for the treatment of several illnesses such as malaria, diarrhea, rheumatism, high blood pressure, and diabetes. This study aims to determine the level of toxicity of a 70 % ethanol extract of the root of that plant (HARv) and to evaluate its hypoglycemic and anti-hyperglicemic activities. It occurs that HARv shows no toxicity when administered orally to rats up to a concentration of 5000 mg/kg of body weight. However, doses of 500, 700 and 1000 mg/kg of body weight lead to hypoglycemia when HARv is administered via the oral route. Similar to the effect of glibenclamide (in a concentration of 10 mg/kg of body weight), concentrations of 700 and 1000 mg/kg of body weight of HARv significantly reduce hyperglycemia induced by the administration of 4 g/kg of body weight of glucose. The presence of saponins, flavonoids, and tannoids in the extract may cause the observed hypoglycemic and anti-hyperglycemic effects. We infer from this study that 70 % ethanol extract of the roots of Rauwolfia vomitoria is not toxic when administered orally to rats. In addition, HARv shows hypoglycemic and anti-hyperglycemic effects, explaining its use in traditional medicine for the treatment of diabetes

Projet d'institutionnalisation de l'approche écosanté : rapport final

A la faveur de l'appui technique et financier du Centre de recherches pour le développement international (CRDI) en mai 2007, l'approche écosystème et santé humaine a été expérimentée dans les universités et institutions supérieures de formation en Afrique de l'Ouest et du Centre. Le projet vise à intégrer l'approche écosanté dans les universités d'Abomey Calavi, de Ouagadougou, d'Abobo Adjamè, de Cocody, l'Institut International de l'Eau et de l'Environnement (2iE) et l'Ecole Nationale Supérieure Polytechnique de Yaoundé. De façon spécifique, il s'agit : - D'intégrer le module écosanté dans des programmes de formation identifiés ou existants ; - Promouvoir la recherche en EcoSanté au niveau des étudiants de ces programmes et de leurs enseignants ; - Pérenniser le processus grâce à la mise en place des mécanismes viables de bonne gouvernance et de mobilisation de ressources financières complémentaires..

Acute toxicity and anti-ulcerogenic activity of an aqueous extract from the stem bark of Terminalia superba Engl. and Diels (Combretaceae)

ABSTRACT Terminalia superba is a plant used in traditional medicine to treat many illnesses particularly gastro-intestinal disorders. This study was aimed to evaluate the acute toxicity and gastric anti-ulcer activity of an aqueous extract of Terminalia superba (AETs). The LD 50 was determined by the graphic method o