Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Análisis de la situación actual y de factibilidad para la puesta a punto del taller de mantenimiento de material rodante Zaragoza del Sistema de Transporte Colectivo.

Este presente trabajo de investigación describe la problemática que existe en la infraestructura del Taller de Mantenimiento Zaragoza y ofrece alternativas de solución para dichos problemas. Se concibió por la necesidad de dar solución a las inconformidades manifestadas por los trabajadores del Taller, ya que existen condiciones inadecuadas que afectan a la operación dentro de las áreas de trabajo, lo cual ha provocado que exista un ambiente de trabajo inconveniente, baja productividad, así como el riesgo latente que conlleva trabajar en estas condiciones .-Tesina I7.194