Are Good Jobs Possible in the Deep South?

This paper addresses that gap by presenting original data collected from one manufacturing community – Anniston, Alabama. Media reports have documented injuries and unsafe working conditions across the South resulting in loss of life and limb while politicians sing the praises of economic development and job creation. This report takes an in-depth look at the costs and benefits of the manufacturing industry's growth by surveying workers across one city and residents living in the shadows of large manufacturing plants. The report identifies unsafe working conditions and unequal opportunity

The Regulation of Mammary Cell Growth: Determining the Role of Clock

Changes in modern lifestyle such as lack of sleep, stress, and light exposure late at night are associated with increased rates of breast cancer. Most physiological processes, including growth, development, and metabolism, are controlled by circadian clocks. Circadian clocks respond to environmental cues to synchronize internal physiological processes, and thus, the disruption of this system may be responsible for this connection. The master clock in the brain coordinates peripheral circadian clocks located in every tissue of the body, including the mammary gland, and the core circadian component CLOCK regulates circadian oscillation of gene expression. Currently, the physiological function of the mammary clock, and the role of CLOCK in mammary cell growth and differentiation, are unknown. Our objective was to determine if the molecular clock controls mammary epithelial cell growth. shRNA specific for Clock was transfected into a normal mouse mammary epithelial cell line, HC-11. Q-PCR and western blot analysis showed shClock transfection significantly reduced Clock mRNA and protein abundance. Temporal analysis of molecular clock gene Per1 showed loss of circadian oscillation in shClock transfected cells, indicating loss of molecular clock function. Cyclin D1 (Ccnd1) expression was elevated in shClock transfected cells, and growth curve analysis revealed that shClock transfected cells had significantly shorter doubling time than HC-11 control cells. These findings support that CLOCK regulates mammary epithelial cell growth and suggests that disruption of circadian clock mechanisms may lead to cancer by altering cell growth regulation

Alien Registration- Nyberg, Emily (Auburn, Androscoggin County)

https://digitalmaine.com/alien_docs/22665/thumbnail.jp

Transformative Variations: The Uses and Abuses of the Transformative Use Doctrine in Right of Publicity Law

In 2001, the California Supreme Court embarked upon a novel experiment in its right of publicity jurisprudence. The court imported a single element from copyright\u27s fair use analysis. That element—transformative use—has since become an enormously important defense for publicity defendants. Unfortunately, the transformative use doctrine is notoriously protean, and has resulted in significant confusion in publicity law that almost certainly chills protected speech. Many courts seem to lack a clear idea of what a sophisticated transformative use analysis should even look like. This article unpacks these issues and proposes improvements to this difficult legal area

The Status of Women In Missouri: A Comprehensive Report of Leading Indicators and Findings

The status of women in Missouri reflects the status of women throughout the United States. Missouri women have the same opportunities, but also face similar challenges. The Institute of Public Policy, in concert with an academic advisory committee at the University of Missouri, has worked diligently to examine existing data, analyze actionable steps at the state level, and understand women's successes and challenges through a series of focus groups across the state. These focus groups gave the researchers the opportunity to hear from very engaged and diverse groups of women, and also a group of men

Profiling employers involved in Apprenticeship Trailblazer groups

This study is the first to analyse the representativeness of apprenticeship Standards Trailblazer groups. Trailblazers set the occupational profile, knowledge, skills and behaviours, and EPAs within apprenticeships. Standards take a long time to develop and representation on them requires a significant organisational commitment. The analysis is based on the employment size and sector of employers represented on Trailblazer groups. Whilst the remit of Trailblazers is to represent employers likely to use the apprenticeship, this study has shown that not all Trailblazer groups do. Some Trailblazers have very good sectoral representation and include all of the main sectors that employ the Standard related occupations. Some do not and exclude key sectors some of which employ up to one quarter of related occupations. However, the main limitation of Trailblazer groups is their over representation of large employers, and their under representation of medium and small employers. This happens on all (for small employers) or most (for medium employers) groups. It is not the case that small and medium sized employers are represented through other organisations. Very few of these organisations are sector or employer representative organisations. Most are training providers or professional/membership bodies. A large number of organisations are represented across all of the Trailblazers, 5,589 across the 646 Standards. We estimate that around one in ten are other organisations. Most of these are representative organisations but a similar number are training providers. This study has also shown that a number of employer and other organisations sit on a large number and wide range of Trailblazers. This in itself is not an issue. It can demonstrate the commitment of employers and other organisations to apprenticeships and workforce development. However, this needs to be monitored to ensure that Standards are representative across employers that are likely to use them. Undertaking the analysis for this study has been challenging because the data on Trailblazer representation is not organised in any way. There is no information on the sector, employment size, type and geographical spread of organisations. Nor is there any information on the sectoral and size spread of Standard related occupations that could be used to make an assessment of the representativeness of the organisations which sit on the Trailblazers. Such information should be collected as the norm for all organisations that are represented on Trailblazers. In order to assist future analysis, there should be agreement on a basic set of standardised information to be collected about organisations, so their representativeness can be assessed, along with an analysis of the employment profile of Standard related occupations

The Addition of the Charlson Comorbidity Index to the GRACE Risk Prediction Index Improves Prediction of Outcomes in Acute Coronary Syndrome

Patients with cardiovascular disease have increased risk of poor outcomes when coexisting illnesses are present. Clinicians, administrators, and health services researchers utilize risk adjustment indices to stratify patients for various outcomes. The GRACE Risk Prediction Index (GRPI) was developed to risk stratify patients who experienced an acute coronary syndrome (ACS) event. GRPI does not account for the presence of comorbid conditions. The objective of this study was to compare the ability of the GRPI and the Charlson Comorbidity Index (CCI), used independently or combined, to predict mortality or secondary coronary events in patients admitted for ACS. Data were obtained from an academic health system's ACS registry. Outcomes included inpatient and 6-month postdischarge mortality and occurrence of secondary cardiovascular events or revascularization procedures. Logistic regression derived C statistics for CCI, GRPI, and CCI-GRPI predictive models for each outcome. Likelihood ratio tests determined the contribution of CCI when added to GRPI models. Complete data were available for 1202 patients. The GRPI model had the greatest C statistic when predicting inpatient mortality (0.73); the GRPI-CCI combined model C statistic was 0.81 when predicting death during the follow-up period; and C statistics for all 3 models were similar in predicting secondary events (0.57?0.60). The likelihood ratio analysis demonstrated that adding CCI to GRPI models was beneficial primarily for predicting secondary events. CCI is a useful addition to GRPI when predicting future cardiac-related events or mortality after an ACS event. It is an acceptable alternative to the GRPI model if data to construct GRPI are not available. (Population Health Management 2014;17:54?59)Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140179/1/pop.2012.0117.pd

The Production Gap Report: 2020 Special Report

To follow a 1.5°C-consistent pathway, the world will need to decrease fossil fuel production by roughly 6% per year between 2020 and 2030. Countries are instead planning and projecting an average annual increase of 2%, which by 2030 would result in more than double the production consistent with the 1.5°C limit

The role and impact of employment charters and procurement by subnational authorities to achieve good work standards

The report is based on interviews with local authority procurement leads, and a review of procurement policies and other documents within the local authorities. Some sub-regional governments in England are resorting to 'soft' legislation in order to develop good work practices in their local labour markets. The study analysed the procurement practices of local authorities on four Mayoral Combined authorities, one of which had a Good Work Charter. The study found that a number of cross-cutting themes emerged: good work is commended, not required; legal risk and uncertainty limits what LADs are willing to try through procurement; resources and staffing limit capacity to do more; there are gaps between policy aims and practical realities; and political backing is important. There is an increasing focus and amount of work being undertaken to increase the local value of LAD spend. The focus is usually on social value and increasing spend going to local suppliers. But increasingly there are attempts to secure improvements in local employment conditions and practices through linking good work dimensions to local authority procurement. The biggest challenges to these efforts is the lack of policy coherence and resource constraints. At a national level, whilst social value and good work are identified as Government commitments, there have been delays in legislation to both the procurement and employment aspects of this. Without these, sub national authorities - MCAs and LADs - are wary of the extent of how far they can go in including stipulations in their contracting processes. Where there has been the greatest political coherence, in Greater Manchester, both the MCA and local authorities have been able to make the greatest strides in linking good work conditions to local procurement. The lack of resources, particularly in terms of staffing, posed challenges for the successful implementation, including in particular the monitoring, of social public procurement. Our findings thereby seem to support previous findings that point to the importance of political commitment and leadership and resources and extend these particularly to practices of linking public procurement and good work