Climate change and socio-economic development in Botswana

No Abstract. Global Journal of Environmental Science Vol. 6 (2) 2007: pp. 107-11

Tree integration in homestead farms in southeast Nigeria: propositions and evidence.

This paper contributes to wider debates on the dominant factors determining the emergence and sustainability of intermediate systems of forest management in developing countries. The theoretical framework and propositions for analysing tree integration in homestead farms are presented, with reference to southeast Nigeria. The paper argues that, first, at the household level, livelihood strategies constitute the main determinant of the decision to integrate trees in homestead farms. Secondly, induced innovation has a wider and more significant role at the community level than at the household level in encouraging the integration of trees in farms. Thirdly, the sustainability of observed patterns of tree integration is influenced by the interaction of environmental, ecological, political, economic and social factors. Based on these propositions, the paper analyses the internal (household) and external (wider community) factors influencing tree integration in homestead farms in southeast Nigeria

Robustness of personal initiative in moderating entrepreneurial intentions and actions of disabled students

Entrepreneurship is vital in the areas of innovation, job creation, nations’ economic and societal advancement. In view of that, personal initiative is seen to be important in moderating the relationship between intention and entrepreneurial action. This study focuses on investigating the moderating role of personal initiative on intention and entrepreneurial action relationship of disabled students. The study followed a descriptive survey where quantitative approach was employed. A total number of 250 questionnaires were administered to disabled students across the tertiary institutions (Universities, Polytechnics and colleges) in Plateau State and Abuja-Nigeria. Analysis of data involved the use of statistical package for social sciences (SPSS version 22.0). Hypotheses were tested using structural equation model. Results revealed that pedagogy significantly and positively influences entrepreneurial actions. Also, personal initiative (proactiveness, resilience and innovation) moderates the relationship between intention and entrepreneurial actions of disabled students

Implementation of genomic medicine for rare disease in a tertiary healthcare system: Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD)

Abstract Background In the United States, rare disease (RD) is defined as a condition that affects fewer than 200,000 individuals. Collectively, RD affects an estimated 30 million Americans. A significant portion of RD has an underlying genetic cause; however, this may go undiagnosed. To better serve these patients, the Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD) was created under the auspices of the Center for Individualized Medicine (CIM) aiming to integrate genomics into subspecialty practice including targeted genetic testing, research, and education. Methods Patients were identified by subspecialty healthcare providers from 11 clinical divisions/departments. Targeted multi-gene panels or custom exome/genome-based panels were utilized. To support the goals of PRaUD, a new clinical service model, the Genetic Testing and Counseling (GTAC) unit, was established to improve access and increase efficiency for genetic test facilitation. The GTAC unit includes genetic counselors, genetic counseling assistants, genetic nurses, and a medical geneticist. Patients receive abbreviated point-of-care genetic counseling and testing through a partnership with subspecialty providers. Results Implementation of PRaUD began in 2018 and GTAC unit launched in 2020 to support program expansion. Currently, 29 RD clinical indications are included in 11 specialty divisions/departments with over 142 referring providers. To date, 1152 patients have been evaluated with an overall solved or likely solved rate of 17.5% and as high as 66.7% depending on the phenotype. Noteworthy, 42.7% of the solved or likely solved patients underwent changes in medical management and outcome based on genetic test results. Conclusion Implementation of PRaUD and GTAC have enabled subspecialty practices advance expertise in RD where genetic counselors have not historically been embedded in practice. Democratizing access to genetic testing and counseling can broaden the reach of patients with RD and increase the diagnostic yield of such indications leading to better medical management as well as expanding research opportunities