1,098 research outputs found
Bleeding with direct oral anticoagulants vs warfarin: clinical experience.
The risk of bleeding in the setting of anticoagulant therapy continues to be re-evaluated following the introduction of a new generation of direct oral anticoagulants (DOACs). Interruption of DOAC therapy and supportive care may be sufficient for the management of patients who present with mild or moderate bleeding, but in those with life-threatening bleeding, a specific reversal agent is desirable. We review the phase 3 clinical studies of dabigatran, rivaroxaban, apixaban, and edoxaban in patients with nonvalvular atrial fibrillation, in the context of bleeding risk and management
Engagement, gamification, and workplace satisfaction: A convergent study of user indicators
The purpose of this study was to determine if there was a correlation between the personal indicators of gamification users, game preferences, and workplace engagement. A three-part survey was deployed through an online, opt-in gamification platform in order to gauge individual user preferences
Cerebral Blood Flow in Relation to Contralateral Carotid Disease an MRA and TCD Study
AbstractObjective: to describe redistribution of cerebral blood flow in patients with severe internal carotid artery (ICA) stenoses in relation to contralateral ICA disease. Methods: sixty-six patients scheduled for carotid endarterectomy (CEA) were grouped according to severity of contralateral stenosis (<30% [group I]; 30–69% [group II]; 70–99% [group III]; occlusion [group IV]. Transcranial Doppler (TCD) and magnetic resonance angiography (MRA) investigations were performed preoperatively. Results: TCD demonstrated a reversed flow in the contralateral anterior cerebral artery (A1segment) and ophthalmic artery in three-quarters of group IV patients (p <0.0001). Group IV patients also exhibited decreased blood flow velocity in the contralateral middle cerebral artery (p =0.001). MRA showed increased ipsilateral ICA and basilar artery (BA) blood flow volumes (Q-flows) in group IV patients when compared to the other groups (p <0.001). No changes in total Q-flow (ICAs+BA) were found. Conclusions: in patients considered for CEA, the severity of the contralateral ICA disease is an important determinant of the pattern of blood flow redistribution through the anterior communicating pathway and ophthalmic artery. Significant flow redistribution through the posterior communicating pathway occurs especially in patients with contralateral ICA occlusion
The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial
10.1186/1471-2318-13-88BMC Geriatrics131
EuroQol values for economic modeling quality of life after infrainguinal bypass grafting surgery:A rectification [1]
EuroQol values for economic modeling quality of life after infrainguinal bypass grafting surgery:A rectification [1]
The impact of hunting on tropical mammal and bird populations
Hunting is a major driver of biodiversity loss, but a systematic large-scale estimate of hunting-induced defaunation is lacking. We synthesized 176 studies to quantify hunting-induced declines of mammal and bird populations across the tropics. Bird and mammal abundances declined by 58% (25 to 76%) and by 83% (72 to 90%) in hunted compared with unhunted areas. Bird and mammal populations were depleted within 7 and 40 kilometers from hunters’ access points (roads and settlements). Additionally, hunting pressure was higher in areas with better accessibility to major towns where wild meat could be traded. Mammal population densities were lower outside protected areas, particularly because of commercial hunting. Strategies to sustainably manage wild meat hunting in both protected and unprotected tropical ecosystems are urgently needed to avoid further defaunation
Does clinician continuity influence hearing aid outcomes?
OBJECTIVE : To evaluate whether clinician continuity is associated with successful hearing aid outcomes. DESIGN : A prospective cohort study. Clinician continuity was defined as occurring when apatient was cared for by the same clinician for the hearing assessment, hearing aid selection process, hearing aid fitting and programming, and subsequent hearing aid fine tuning appointments. The hearing aid outcome measures included self-reported hearing aid use,benefit and satisfaction as well as self-reported handling skills and problems experienced
with hearing aids. STUDY SAMPLE : Four hundred and sixty-eight adult hearing aid users (mean age 73.9 years ± 10.9) and 26 qualified audiologists (mean age 34 years ± 6.34) recruited from a single hearing clinic in Perth, Western Australia.
RESULTS : There were no significant differences in hearing aid outcomes between participants who experienced clinician continuity and those who did not.
CONCLUSIONS : Within a controlled practice setting, hearing aid outcomes may not be adversely effected if services are provided by more than one clinician.R. Bennett is funded by an Australian postgraduate award scholarship
through the School of Surgery at The University of Western Australia.http://www.tandfonline.com/loi/iija202017-05-31hb2017Speech-Language Pathology and Audiolog
Auditory-cognitive training for adult cochlear implant recipients : a study protocol for a randomised controlled trial
BACKGROUND: There is an urgent need to develop new therapies to improve cognitive function in adults following
cochlear implant surgery. This study aims to determine if completing at-home computer-based brain training
activities improve memory and thinking skills in adults following their first cochlear implant.
METHODS: This study will be conducted as a single-blind, head-to-head, randomised controlled trial (RCT). It will
determine whether auditory training combined with adaptive computerised cognitive training will elicit greater
improvement in cognition, sound and speech perception, mood, and quality of life outcomes in adult cochlear
implant recipients, when compared to auditory training combined with non-adaptive (i.e. placebo) computerised
cognitive training. Participants 18 years or older who meet the clinical criteria for a cochlear implant will be
recruited into the study.
RESULTS: The results of this trial will clarify whether the auditory training combined with cognitive training will improve
cognition, sound and speech perception, mood, and quality of life outcomes in adult cochlear implant recipients.
DISCUSSION: We anticipate that our findings will have implications for clinical practice in the treatment of adult
cochlear implant recipients.William Demant Foundation and Ear Science Institute Australia.http://www.trialsjournal.compm2022Speech-Language Pathology and Audiolog
- …