469 research outputs found
Testing the Paleolithic-human-warfare hypothesis of blood-injectiion phobia in the Balitmore ECA Follow-up Study-Towards a more etiologically-based conceptualization for DSM-V
Objective:
The
research
agenda
for
the
fifth
edition
of
the
Diagnostic
and
Statistical
Manual
of
Mental
Disorders
(DSM-V)
has
emphasized
the
need
for a
more
etiologically-based
classification
system,
especially
for
stress-induced
and
fear-circuitry
disorders.
Testable
hypotheses
based
on
threats
to
survival
during
particular
segments
of
the
human
era
of
evolutionary
adaptedness
(EEA)
may
be
useful
in
developing a
brain-evolution-based
classification
for
the
wide
spectrum
of
disorders
ranging
from
disorders
which
are
mostly
overconsolidationally
such
as
PTSD,
to
fear-circuitry
disorders
which
are
mostly
innate
such
as
specific
phobias.
The
recently
presented
Paleolithic-human-warfare
hypothesis
posits
that
bloodâinjection
phobia
can
be
traced
to a
âsurvival
(fitness)
enhancingâ
trait,
which
evolved
in
some
females
of
reproductive-age
during
the
millennia
of
intergroup
warfare
in
the
Paleolithic
EEA.
The
study
presented
here
tests
the
key a
priori
prediction
of
this
hypothesisâthat
current
bloodâinjection
phobia
will
have
higher
prevalence
in
reproductive-age
women
than
in
post-menopausal
women.
Method:
The
Diagnostic
Interview
Schedule
(version
III-R)
,
which
included a
section
on
blood
and
injection
phobia,
was
administered
to
1920
subjects
in
the
Baltimore
ECA
Follow-up
Study.
Results:
Data
on
BII
phobia
was
available
on
1724
subjects
(1078
women
and
646
males)
.
The
prevalence
of
current
bloodâ
injection
phobia
was
3.3%
in
women
aged
27â49
and
1.1%
in
women
over
age
50
(OR
3.05,
95%
CI
1.20â7.73)
.
[The
corresponding
figures
for
males
were
0.8%
and
0.7%
(OR
1.19,
95%
CI
0.20â7.14)]
.
Conclusions:
This
epidemiological
study
provides
one
source
of
support
for
the
Paleolithic-human-warfare
(Paleolithic-threat)
hypothesis
regarding
the
evolutionary
(distal)
etiology
of
bloodletting-related
phobia,
and
may
contribute
to a
more
brain-
evolution-based
re-conceptualization
and
classification
of
this
fear
circuitry-related
trait
for
the
DSM-V.
In
addition,
the
finding
reported
here
may
also
stimulate
new
research
directions
on
more
proximal
mechanisms
which
can
lead
to
the
development
of
evidence-based
psychopharmacological
preventive
interventions
for
this
common
and
sometimes
disabling
fear-circuitry
disorder
Detection of Progressive Deterioration in Early Onset Schizophrenia with a New Statistical Method
Much controversy exists over whether the course of schizophrenia, as defined by the lengths of repeated community tenures, is progressively ameliorating or deteriorating. This article employs a new statistical method proposed by Wang and Chen (2000) to analyze the Denmark registry data in Eaton, et al (1992). The new statistical method correctly handles the bias caused by induced informative censoring, which is an interaction of the heterogeneity of schizophrenia patients and long-term follow-up. The analysis shows a progressive deterioration pattern in terms of community tenures for the full registry cohort, rather than a progressive amelioration pattern as reported for a selected sub-cohort in Eaton, et al (1992). When adjusted for the long-term chronicity of calendar time, no significant progressive pattern was found for the full cohort
1865-07-12 Surgeon William W. Eaton seeks information on Timothy Fowler of Company K
https://digitalmaine.com/cw_me_16th_regiment_corr/1430/thumbnail.jp
Associations of depression status and hopelessness with breast cancer.
This study extended the literature by examining whether three profiles of depression predicted breast cancer status. In 1076 women of the Baltimore Epidemiologic Catchment Area study, depression status and hopelessness were measured at baseline and breast cancer status was ascertained 24âyears later. Double depression, but not major depression or dysthymia, was associated with breast cancer. Hopelessness predicted fewer new cases of breast cancer. When double depression and hopelessness were simultaneously entered as predictors, the regression weights of both predictors increased. The role of severe and extended duration depression as well as possible explanations for unexpected findings are discussed
Prevalence and Comorbidity of Alcohol Dependence, Depression, and Anxiety Disorders in their Association with the Serotonin Transporter Gene
Introduction: Depression and anxiety disorders have been found to be highly comorbid in epidemiologic studies. Furthermore, the presence of the short allele of the serotonin transporter gene (5HTT) has been found to be associated with an increased prevalence of major depressive disorder (MDD), bipolar disorder, anxiety disorders, as well as personality disorders.
Aims: To examine the association of the 5HTT and the risk of prevalence and comorbidity for, Major Depressive Disorder, Bipolar Disorder, as well as several anxiety disorders in a sample of the Baltimore Epidemiologic Catchment Area Survey Follow-up Study.
Methods: We estimated lifetime prevalence and the risk of comorbidity for Major Depressive Disorder, Bipolar Disorder, Panic Disorder, Agoraphobia, Social Phobia, Obsessive Compulsive Disorder, Generalized Anxiety Disorder, Simple Phobia, Dysthymic Disorder. All subjects were evaluated by a psychiatrist using the Schedules for Clinical Assessment in Neuropsychiatry. In addition, we assessed the impact of the carrier status into the prevalence and comorbidity estimates of the aforementioned disorders.
Results: A significant association was found between an increased risk for the lifetime prevalence of Panic Disorder and the 5-HTT âsâ polymorphism (OR (95% CI): 3.10 (1.33; 7.27). A higher risk for lifetime prevalence of Panic Disorder and the 5-HTT âsâ polymorphism was found in women carriers as compared to men(OR (95% CI): 3.54 (1.41; 8.91)). Panic Disorder had significant comorbidities with Alcohol Dependence, Alcohol Abuse, MDD, Bipolar Disorder, Agoraphobia, Social Phobia, OCD, Simple Phobia and Adjustment Disorder. These associations were higher in women as compared to men carriers. Comorbidities for Simple Phobia were highly significant in males for most anxiety disorders and MDD.
Conclusions: There was a high prevalence of comorbidity amongst most of the anxiety disorders in this population. The effect of the 5HTT carrier status was only associated with an increment in the risk of having a Panic Disorder
Checking Assumptions in Latent Class Regression Models via a Markov Chain Monte Carlo Estimation Approach: An Application to Depression and Socio-Economic Status
Latent class regression models are useful tools for assessing associations between covariates and latent variables. However, evaluation of key model assumptions cannot be performed using methods from standard regression models due to the unobserved nature of latent outcome variables. This paper presents graphical diagnostic tools to evaluate whether or not latent class regression models adhere to standard assumptions of the model: conditional independence and non-differential measurement. An integral part of these methods is the use of a Markov Chain Monte Carlo estimation procedure. Unlike standard maximum likelihood implementations for latent class regression model estimation, the MCMC approach allows us to calculate posterior distributions and point estimates of any functions of parameters. It is this convenience that allows us to provide the diagnostic methods that we introduce.
As a motivating example we present an analysis focusing on the association between depression and socioeconomic status, using data from the Epidemiologic Catchment Area study. We consider a latent class regression analysis investigating the association between depression and socioeconomic status measures, where the latent variable depression is regressed on education and income indicators, in addition to age, gender, and marital status variables. While the fitted latent class regression model yields interesting results, the model parameters are found to be invalid due to the violation of model assumptions. The violation of these assumptions is clearly identified by the presented diagnostic plots.
These methods can be applied to standard latent class and latent class regression models, and the general principle can be extended to evaluate model assumptions in other types of models
A Systematic Review of Evidence for the Clubhouse Model of Psychosocial Rehabilitation
The Clubhouse Model has been in existence for over sixty-five years; however, a review that synthesizes the literature on the model is needed. The current study makes use of the existing research to conduct a systematic review of articles providing a comprehensive understanding of what is known about the Clubhouse Model, to identify the best evidence available, as well as areas that would benefit from further study. Findings are summarized and evidence is classified by outcome domains. Fifty-two articles met the selection criteria of Randomized Clinical Trials (RCT\u27s), quasi-experimental studies, or observational studies for domains of employment (N = 29); quality of life/satisfaction (N = 10); reductions in psychiatric hospitalization(s) (N = 10); social relationships (N = 10); education (N = 3); and health promotion activities (N = 2). RCT results support the efficacy of the Clubhouse Model in promoting employment, reducing hospitalization(s), and improving quality of life. Quasi-experimental and observational studies offer support in education and social domains. The findings from this review indicate that Clubhouses are a promising practice but additional studies using rigorous methods that report the strength of the outcomes are needed to evaluate Clubhouse programs with fidelity to the Clubhouse Model
"After my husband's circumcision, I know that I am safe from diseases": Women's Attitudes and Risk Perceptions Towards Male Circumcision in Iringa, Tanzania.
While male circumcision reduces the risk of female-to-male HIV transmission and certain sexually transmitted infections (STIs), there is little evidence that circumcision provides women with direct protection against HIV. This study used qualitative methods to assess women's perceptions of male circumcision in Iringa, Tanzania. Women in this study had strong preferences for circumcised men because of the low risk perception of HIV with circumcised men, social norms favoring circumcised men, and perceived increased sexual desirability of circumcised men. The health benefits of male circumcision were generally overstated; many respondents falsely believed that women are also directly protected against HIV and that the risk of all STIs is greatly reduced or eliminated in circumcised men. Efforts to engage women about the risks and limitations of male circumcision, in addition to the benefits, should be expanded so that women can accurately assess their risk of HIV or STIs during sexual intercourse with circumcised men
Fertility trajectories and later-life depression among parents in England
We examine pathways between indicators of fertility tempo/quantum and depressive symptoms among parents aged 55+ with at least two children, using three waves of the English Longitudinal Study of Ageing. Using standard regression approaches and path analysis within the structural equation framework, we also investigate whether fertility trajectories mediated the association between childhood disadvantage and later-life depression. Results provide limited support for direct influences of fertility trajectories on depression, but indicate indirect linkages for both women and men. Associations are mediated by partnership history, social support, wealth, later-life smoking, and functional limitation. Associations between childhood disadvantage and later-life depression are partially mediated by fertility stressors. Results confirm the influence of life course experiences on depression at older ages and demonstrate the interlinked role of family and other life course pathways on later-life well-being
- âŠ