Uncommon site of prostatic adenocarcinoma metastasis thyroid cartilage

Aim: Prostate cancer is the most common malignancy in men and tends to metastases to bone, lung, liver, pleura and adrenal glands. Herein we presented a case of prostate carcinoma with an atypical site of metastasis. Method: An 83-years-old male patient with a known diagnosis of prostate cancer and newly developed mass in the left lung was referred to fludeoxyglucose (FDG) positron emission tomography (PET)/computerized tomography (CT) and Ga-68 prostate membrane antigen (PSMA)/PET/CT. Results: FDG PET/CT demonstrated hypermetabolic mass located in apicoposterior segment of the left lung and multiple hypermetabolic metastatic lesions in skeletal system including the right side of the thyroid cartilage. Then, patient underwent Ga-68 PSMA PET/CT due to an increase in prostate-specific antigen level (12.39 ng/mL). Ga-68 PSMA PET/CT revealed PSMA accumulation in the mass located in left lung, intense PSMA uptake in the prostatic gland and increased uptake in the widespread metastatic lesions of skeletal system involving the right side of the thyroid cartilage. Conclusion: Ga-68 PSMA is a useful tool for evaluating the distant and unexpected metastases of prostate cancer. Cartilaginous tissue is a resistant site for metastasis because its rich structure of protease inhibitors prevents the destruction of extracellular matrix components. In this patient with advanced stage prostate cancer, both FDG and PSMA uptake were observed in the thyroid cartilage metastasis

Corticomedullary Mixed Tumor of the Adrenal Gland with Apparent F-18-Fluorodeoxyglucose Activity But No 68GA-DOTATATE Uptake on Positron Emission Tomography/Computed Tomography

Corticomedullary mixed tumor (CMT) is a single adrenal tumor mass composed histologically by an admixture of adrenal cortical and medullary cells. It is a rare condition, with approximately 20 cases reported to date. To our knowledge, the positron emission tomography (PET) imaging findings of this mostly benign tumor have not been reported in the literature. We present a case of CMT who was evaluated with both F-18-fluorodeoxyglucose (F-18-FDG) and Ga-68-DOTATATE. The hypermetabolic tumor seen on F-18-FDG PET/computed tomography scan showed no abnormal uptake by Ga-68-DOTATATE