Attractiveness of the Russian regional space as a living environment: Aspect of the migrants' behavioural rationality

This study focuses on the rationality of the migrants' behaviour. We hypothesise that the migration growth rate depends on the territory attractiveness for living. The rational behaviour is defined as the direct dependence of the migrations on the characteristics of the territory attractiveness. The irrational behaviour means that the reverse dependence is present. The direct dependence is recognised if the level of the migrants' positive reactions to the factors of the territory attractiveness is no less than 30 % from the maximum. 83 subjects of the Russian Federation were clustered based on 12 objective characteristics of the life's quality. We distinguished the largest Middle Cluster, which includes 56 regions. Further we transformed the panel data for the period from 2005 to 2015 into the array of the coefficients of correlations between the characteristics of the territory attractiveness and the migration growth rates in the regions. Using these characteristics, the regions were clustered again. The regional types of the Middle cluster with the rational and irrational behaviours include 22 regions each. The level of the migrants' positive reactions to the factors of the territory attractiveness is 44.1 % for the first (rational) regional type and 42.5 % for the second (irrational) type. The regional type with the indifferent behaviour includes 12 regions. The level of the migrants' reactions to the characteristics of these territory attractiveness is just 5.8 %. Based on the regression models of the migration coefficient for each cluster type, we have provided recommendations for managing the migration flows using the differential approach. © 2019 Petrov M. B., Kurushina E. V., Druzhinina I. V. Text

REALIZATION OF FEDERAL AND REGIONAL PROGRAMS OF INFERTILITY TREATMENT

High frequency of infertility in the Irkutsk region (18—20 %) sharply limits population reproduction. Tubo-peritoneal factor (97,3 %), man's infertility (20 %) are leading factors of infertility in Irkutsk region. It predisposes wide using of IVF as the main way of reproductive problems solution in population. Efficiency of IVF programs depends on such factors as age of patients; duration and causes of infertility

ESTIMATION OF EFFICIENCY OF A TECHNIQUE OF TRANSVAGINAL PUNCTURES OF OVARIES WITH WASHING OF FOLLICLES IN IVF CYCLES

«Poor» ovarian response in standard IVF protocols leads to the difficulty or even impossibility of ensuring the stage of transfer of embryos. A technique of transvaginal puncture with washing of follicles by buffer solution is performed in patients with «poor» ovarian response. This article presents the analysis of TVP in 495 IVF initiated treatment cycles. A smaller number of mature oocytes and embryos are received in the process of controlled ovarian hyperstimulation in patients with washing of follicles, however, the possibility of pregnancy is comparable to the overall IVF results

Pathology of mammary glands in women with reproductive disorders and chronic endometritis

Background. The last decades are devoted to the search for various factors leading to the development of benign breast diseases, which are the risk of breast cancer. In gynecological diseases, the frequency of benign processes in the mammary glands increases to 76-97.8 %. Aims: this research is devoted to the study of the prevalence and structure of breast pathology in women with chronic endometritis and reproductive disorders. Materials and methods. The study included patients with reproductive disorders: 50 patients with histological verification of the diagnosis of chronic endometritis and 50 patients without chronic endometritis. Hormonal examination was carried out using radioimmunoassay and immunoenzymatic methods. Methods of mathematical statistics implemented Statistica 6.1 (USA) were used parametric criteria: Student's t-test and Fisher's F-criterion, the nature of the distribution was estimated using the methods of Kolmogorov - Smirnov with a significance level smaller and equal to 5 % (p < 0.05). To confirm the fact that the observed differences between the products of A x D and B x C are not random, we used the х2 criterion. Results and conclusions. In women with chronic endometritis, the pathology of the mammary glands is characterized by the presence of ectasia of the ducts of the mammary gland; clinically, it is manifested by lactorrhea. Benign dysplasia of mammary glands is accompanied by the presence of hyperestrogenia, hypoprogesteronemia, which is typical for ovarian dysfunction. It is possible to use a pathogenetically reasonable combination correction: anti-inflammatory therapy and the use of gestagens in women with reproductive disorders and chronic endometritis

Ectopic pregnancy and acute appendicitis during intrauterine pregnancy after in vitro fertilization

The paper presents a clinical case of the Patient T., 34years old, who underwent the treatment in the Department of ART of the Regional Perinatal Center for tubal peritoneal infertility for seven years. In the anamnesis: one spontaneous uterine pregnancy, culminating in medical abortion for up to 12 weeks, treatment for chronic salpingo-oophoritis, tubectomy on the right side for a progressing ectopic pregnancy. The patient denied the presence of Chlamydia infection in the anamnesis. Studies on sexually transmitted infections before the 1VF program were negative. During laparoscopic tubectomy, no endometriotic foci were found. There were four programs of ART in anamnesis: in 2009, 2012, 2014,2016. During the fourth ART program in 2016, two embryos were transferred to the uterine cavity, resulting in a uterine pregnancy in combination with an ectopic pregnancy diagnosed in the ultrasound study at 4 to 5 weeks of gestation, in the absence of clinical symptoms. The patient underwent emergency laparoscopic tubectomy on the left, the course of the postoperative period proceeded without complications. Later, in the period of uterine pregnancy of 7-8 weeks, with a clinical picture of acute appendicitis, the woman was hospitalized in the surgical department where she underwent laparoscopic appendectomy. Later the pregnancy proceeded without complications, at 39 weeks the planned cesarean section was performed, a girl weighing 3480 grams, 51 cm long with an Apgar score of 9-10 points was extracted on the operation. The course of the early postoperative period without complications, the patient was discharged with the child on the 4th day

Sleep features in menopausal women (literature review)

The article reviews the literature of domestic and foreign researchers devoted to the somnological aspects of the menopausal period in women. Age-related changes in the structural organization of sleep are shown with a deficiency of sex steroids, also and in the gender aspect. A high frequency of sleep disorders in menopausal women, reaching 60 %, has been revealed. However, the results of studies on complaints of sleep disorders depending on the climacteric phase are ambiguous, which may be due to ethnicity. Data on some pathogenetic mechanisms of the formation of the most frequent sleep disorders in menopausal women - insomnia, obstructive sleep apnea syndrome and fibromyalgia - are described. The results of polysomnography in these pathological states are presented, indicating a decrease in sleep efficiency, a change in its "architecture", and a longer waking time during the night with insomnia; a significant increase in the apnea/hypopnea index, a delay in the phase of fast sleep, a decrease in the duration of deep stages of sleep and a decrease in its effectiveness - in obstructive sleep apnea syndrome. The social and medical consequences of sleep disorders and their comorbidity with such pathological conditions as mental disorders, obesity, cardiovascular diseases, oncology, disorders of carbohydrate metabolism, bronchial asthma, mortality are noted

RISK FACTORS AND CRITERIA FOR PREDICTION OF OVARIAN HYPERSTIMULATION SYNDROME

Ovarian hyperstimulation syndrome (OHSS) is the most frequent and dangerous complication of IVF programmers. Evaluation of OHSS risk factors allows to perform differentiated, approaches to controlled ovarian stimulation. This article presents the results of OHSS risk factors analysis in 775 IVF cycles. It was found that young age (< 35 years), PCOS, tubal factor of infertility and low BMI (< 25 kg/m2) are the significant risk factors for OHSS

Assisted hatching in cryopreservation protocols in patients with tuboperitoneal infertility

At present, the problem of increasing the effectiveness of programs of assisted reproductive technologies and successful infertility treatment is still relevant. Assisted hatching used in the devitrificated embryo transfer facilitates the exit of the embryo from the pellucide zone. Yet the clinical efficacy of assisted hatching is relevant and debatable. There are no clear indications for the use of this technology, and no groups of patients have been identified.The aim of the study. To assess the effectiveness of laser hatching in the frozenthawed embryo transfer programs in patients with tuboperitoneal infertility.Materials and methods. We examined 300 women with tuboperitoneal infertility who had their embryos frozen for transfer. Inclusion criteria: age from 18 to 35 years; tuboperitoneal infertility; embryos cryopreserved for transfer. Exclusion criteria: age more than 36 years; other infertility factors. Women were divided into 2 groups: group 1 – women who had a frozen-thawed embryo transfer with preliminary laser hatching (n = 137); group 2 – control group (n = 163).Results. There were no differences between the groups in the mean age, body mass index and the age at menarche. According to the results of the embryological stage, there were also no differences in the number and quality of frozen embryos. The pregnancy rate in the group with preliminary laser hatching was 44.5 %, which is significantly higher than in the control group (42.3 %; р ≤ 0.001). We also found statistically significant differences in pregnancy outcomes: in the frequency of spontaneous miscarriages – 13.1 % and 20.2 % respectively (p ≤ 0.001), in the frequency of term deliveries – 30.7 % and 22.1 % respectively (p ≤ 0.001).Conclusion. In our study, the using laser hatching in women with tuboperitoneal infertility positively affected the embryos implantation in the cryopreservation protocols. Pregnancy and live birth rates are higher after using hatching technology, and the frequency of miscarriages up to 12 weeks is lower. This provide an opportunity to further study the effect of hatching on long-term outcomes, such as gestation course and childbirth

ESTIMATION OF EFFICIENCY OF FROZEN-THAWED EMBRYOS TRANSFERS IN IVF CYCLES

Cryo-embryos transfer is less expensive and less aggressive method in compare with repeated ovarian stimulation and transfer of «fresh» embryos. The article presents the analysis of influence of various factors on the efficiency of cryo-embryo transfers in 118 IVF cycles. The main success criteria is the quality of thawed embryos

Genomic landscape of a relict fir-associated fungus reveals rapid convergent adaptation towards endophytism

Comparative and pan-genomic analyses of the endophytic fungus Pezicula neosporulosa (Helotiales, Ascomycota) from needles of the relict fir, Abies beshanzuensis, showed expansions of carbohydrate metabolism and secondary metabolite biosynthetic genes characteristic for unrelated plant-beneficial helotialean, such as dark septate endophytes and ericoid mycorrhizal fungi. The current species within the relatively young Pliocene genus Pezicula are predominantly saprotrophic, while P. neosporulosa lacks such features. To understand the genomic background of this putatively convergent evolution, we performed population analyses of 77 P. neosporulosa isolates. This revealed a mosaic structure of a dozen non-recombining and highly genetically polymorphic subpopulations with a unique mating system structure. We found that one idiomorph of a probably duplicated mat1-2 gene was found in putatively heterothallic isolates, while the other co-occurred with mat1-1 locus suggesting homothallic reproduction for these strains. Moreover, 24 and 81 genes implicated in plant cell-wall degradation and secondary metabolite biosynthesis, respectively, showed signatures of the balancing selection. These findings highlight the evolutionary pattern of the two gene families for allowing the fungus a rapid adaptation towards endophytism and facilitating diverse symbiotic interactions