BRAMS: The Belgian RAdio Meteor Stations

In the last months, the Belgian Institute for Space Aeronomy has been developing a Belgian network for observing radio meteors using forward scattering technique. This network is called BRAMS for Belgian RAdio Meteor Stations. Two beacons emitting a circularly polarized pure sine wave toward the zenith act as the transmitters at frequencies of 49.97 and 49.99 MHz. The first one located in Dourbes (Southern Belgium) emits a constant power of 150 Watts while the one located in Ieper (Western Belgium) emits a constant power of 50 Watts. The receiving network consists of about 20 stations hosted mainly by radio amateurs. Two stations have crossed-Yagi antennas measuring horizontal and vertical polarizations of the waves reflected off meteor trails. This will enable a detailed analysis of the meteor power profiles from which physical parameters of the meteoroids can be obtained. An interferometer consisting of 5 Yagi-antennas will be installed at the site of Humain in order to determine the angular detection of one reflection point, allowing us to determine meteoroid trajectories. We describe this new meteor observing facility and present the goals we expect to achieve with the network

KIAA0101 Is Overexpressed, and Promotes Growth and Invasion in Adrenal Cancer

Background: KIAA0101 is a proliferating cell nuclear antigen-associated factor that is overexpressed in some human malignancies. Adrenocortical neoplasm is one of the most common human neoplasms for which the molecular causes are poorly understood. Moreover, it is difficult to distinguish between localized benign and malignant adrenocortical tumors. For these reasons, we studied the expression, function and possible mechanism of dysregulation of KIAA0101 in human adrenocortical neoplasm. Methodology/Principal Findings: KIAA0101 mRNA and protein expression levels were determined in 112 adrenocortical tissue samples (21 normal adrenal cortex, 80 benign adrenocortical tumors, and 11 adrenocortical carcinoma (ACC). SiRNA knockdown was used to determine the functional role of KIAA0101 on cell proliferation, cell cycle, apoptosis, soft agar anchorage independent growth and invasion in the ACC cell line, NCI-H295R. In addition, we explored the mechanism of KIAA0101 dysregulation by examining the mutational status. KIAA0101 mRNA (9.7 fold) and protein expression were significantly higher in ACC (p,0.0001). KIAA0101 had sparse protein expression in only a few normal adrenal cortex samples, which was confined to adrenocortical progenitor cells. KIAA0101 expression levels were 84 % accurate for distinguishing between ACC and normal and benign adrenocortical tumor samples. Knockdown of KIAA0101 gene expression significantly decreased anchorage independent growth by 80 % and invasion by 60 % (p = 0.001; p = 0.006). W

Non-Functional Parathyroid Carcinoma: A Review of the Literature and Report of a Case Requiring Extensive Surgery

Parathyroid carcinoma is a rare malignancy, and only accounts for 0.5–2% of cases of primary hyperparathyroidism. Less than 10% of parathyroid carcinomas are non-functional, and as such, they have been rarely reported in the literature. Importantly, margin status at resection is related to prognosis, and only a handful of case reports of non-functional carcinoma note this important parameter. Here we report the first case of non-functional parathyroid carcinoma with negative margins, and review the literature on this rare entity. Whether functional or non-functional, parathyroid carcinoma can often be difficult to differentiate from benign parathyroid adenoma. While diagnosis has been based on clinical and histological criteria, recent data concerning the molecular underpinnings of parathyroid carcinoma may allow for improved accuracy in distinguishing benign and malignant parathyroid tumors

Humanized Mouse Model of Ovarian Cancer Recapitulates Patient Solid Tumor Progression, Ascites Formation, and Metastasis

Ovarian cancer is the most common cause of death from gynecological cancer. Understanding the biology of this disease, particularly how tumor-associated lymphocytes and fibroblasts contribute to the progression and metastasis of the tumor, has been impeded by the lack of a suitable tumor xenograft model. We report a simple and reproducible system in which the tumor and tumor stroma are successfully engrafted into NOD-scid IL2Rγnull (NSG) mice. This is achieved by injecting tumor cell aggregates derived from fresh ovarian tumor biopsy tissues (including tumor cells, and tumor-associated lymphocytes and fibroblasts) i.p. into NSG mice. Tumor progression in these mice closely parallels many of the events that are observed in ovarian cancer patients. Tumors establish in the omentum, ovaries, liver, spleen, uterus, and pancreas. Tumor growth is initially very slow and progressive within the peritoneal cavity with an ultimate development of tumor ascites, spontaneous metastasis to the lung, increasing serum and ascites levels of CA125, and the retention of tumor-associated human fibroblasts and lymphocytes that remain functional and responsive to cytokines for prolonged periods. With this model one will be able to determine how fibroblasts and lymphocytes within the tumor microenvironment may contribute to tumor growth and metastasis, and will make it possible to evaluate the efficacy of therapies that are designed to target these cells in the tumor stroma

Efficacy of bariatric surgery among adolescent patients with super-obesity

Background: We sought to determine if adolescent patients with super-obesity (body mass index, BMI >50 kg/m2) have different outcomes in weight loss and obesity-related co-morbidity (ORC) resolution when compared to patients with a BMI 2. Methods: We identified patients aged 15-21 years who underwent bariatric surgery from 2011 to 2016. Patients were stratified according to the preoperative BMI into BMI greater than 50 kg/m2 (group A) compared to those with BMIs between 30 and 49.9 kg/m2 (group B). Mean change in percent weight loss and rate of ORC resolution were measured. Results: One hundred twenty patients were included, with 21 patients in group A and 99 patients in group B. Patients in group A had a BMI of 56.09 kg/m2, while group B had a BMI of 42.61 kg/m2. Group A's percent weight loss of 30% (45.5 kg) and 41% (62.3 kg), at 1- and 2-year follow-up, respectively. Group B's percent weight loss was 28% (34.7 kg) and 32% (38.8 kg), at 1- and 2-year follow-up, respectively (p < 0.05). There was no difference in ORC resolution rates. Conclusions: We found that group A had greater percent weight loss at 1 and 2 years compared to patients in group B. No significant differences were found in ORC resolution.</p